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Cytoskeleton-associated antigens from African trypanosomes are recognized by self-reactive antibodies of uninfected mice

Published online by Cambridge University Press:  06 April 2009

N. Müller ,
M. Imboden ,
E. Detmer ,
J. M. Mansfield  and
T. Seebeck
N. Müller
Affiliation:
Institut für Allgemeine Mikrobiologie, University of Bern, Baltzerstrasse 4, CH-3012 Bern, Switzerland
M. Imboden
Affiliation:
Institut für Allgemeine Mikrobiologie, University of Bern, Baltzerstrasse 4, CH-3012 Bern, Switzerland
E. Detmer
Affiliation:
Institut für Allgemeine Mikrobiologie, University of Bern, Baltzerstrasse 4, CH-3012 Bern, Switzerland
J. M. Mansfield
Affiliation:
Department of Animal Health and Biomedical Sciences, 1655 Linden Drive, University of Wisconsin, Madison, WI 53706, USA
T. Seebeck
Affiliation:
Institut für Allgemeine Mikrobiologie, University of Bern, Baltzerstrasse 4, CH-3012 Bern, Switzerland
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Summary

Serum from uninfected mice of different strains, as well as from germ-free animals, contains antibodies which react specifically with at least two trypanosomal proteins, I/6 and MARP1. These antibody populations are highly specific for the respective proteins, are of similar affinity as hyperimmune antibodies, and consist of IgM as well as IgG isotypes. Hyperimmune antibody raised against the cross-reacting trypanosomal protein I/6 detects a 60 kDa protein in mouse 3T6 cells, which is a component of the fibroblast cytoskeleton.

Keywords

cytoskeletal-associated antigensAfrican trypanosomesantibody response
Type
Research Article
Information
Parasitology , Volume 107 , Issue 4 , November 1993 , pp. 411 - 417
Copyright
Copyright © Cambridge University Press 1993

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