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The chemotherapy of Eperythrozoon coccoides (Schilling, 1928)

Published online by Cambridge University Press:  06 April 2009

June P. Thurston
June P. Thurston
Affiliation:
National Institute for Medical Research, The Ridgeway, London, N.W. 7*
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Extract

In tests for chemotherapeutic activity, mice were infected with Eperythrozoon coccoides, treated with drugs for 2 days, splenectomized, and treated with drugs for a further 2 days. Blood films were examined from the second day after splenectomy, when control mice showed heavy blood infections.

Neoarsphenamine, aureomycin and terramycin were active.

Tryparsamide, Chloromycetin, alloxan and polyoxyethylene ether, D2, were slightly active.

Many drugs, listed in Table 3, were inactive.

Neoarsphenamine cleared E. coccoides from the blood very rapidly. This action was inhibited by dimercaprol (BAL).

E. coccoides closely resembles Haemobartonella muris in its sensitivity to drugs. Both micro-organisms probably have affinities with the Rickettsiae.

Type
Research Article
Information
Parasitology , Volume 43 , Issue 1-2 , May 1953 , pp. 170 - 174
Copyright
Copyright © Cambridge University Press 1953

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