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cAMP-dependent protein kinase from Plasmodium falciparum: an update

Published online by Cambridge University Press:  21 July 2010

NATHALIE WURTZ ,
CHARLES CHAPUS ,
JEROME DESPLANS  and
DANIEL PARZY
NATHALIE WURTZ
Affiliation:
UMR-MD3, Relation Hôte-Parasites, Pharmacologie et Thérapeutique (Université de la Méditerranée Aix-Marseille II), Institut de Recherche Biomédicale des Armées, antenne de Marseille IMTSSA, Allée du Médecin Colonel Eugène Jamot, Parc du Pharo, BP 60109, 13262 Marseille Cedex 07, France
CHARLES CHAPUS
Affiliation:
UMR-MD3, Relation Hôte-Parasites, Pharmacologie et Thérapeutique (Université de la Méditerranée Aix-Marseille II), Institut de Recherche Biomédicale des Armées, antenne de Marseille IMTSSA, Allée du Médecin Colonel Eugène Jamot, Parc du Pharo, BP 60109, 13262 Marseille Cedex 07, France
JEROME DESPLANS
Affiliation:
UMR-MD3, Relation Hôte-Parasites, Pharmacologie et Thérapeutique (Université de la Méditerranée Aix-Marseille II), Institut de Recherche Biomédicale des Armées, antenne de Marseille IMTSSA, Allée du Médecin Colonel Eugène Jamot, Parc du Pharo, BP 60109, 13262 Marseille Cedex 07, France
DANIEL PARZY*
Affiliation:
UMR-MD3, Relation Hôte-Parasites, Pharmacologie et Thérapeutique (Université de la Méditerranée Aix-Marseille II), Institut de Recherche Biomédicale des Armées, antenne de Marseille IMTSSA, Allée du Médecin Colonel Eugène Jamot, Parc du Pharo, BP 60109, 13262 Marseille Cedex 07, France
*
*Corresponding author: Tel: +334 91 15 01 14. Fax: +334 91 15 01 64. E-mail: [email protected]
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Summary

One of the most important public health problems in the world today is the emergence and dissemination of drug-resistant malaria parasites. Plasmodium falciparum is the causative agent of the most lethal form of human malaria. New anti-malarial strategies are urgently required, and their design and development require the identification of potential therapeutic targets. However, the molecular mechanisms controlling the life cycle of the malaria parasite are still poorly understood. The published genome sequence of P. falciparum and previous studies have revealed that several homologues of eukaryotic signalling proteins, such as protein kinases, are relatively conserved. Protein kinases are now widely recognized as important drug targets in protozoan parasites. Cyclic AMP-dependent protein kinase (PKA) is implicated in numerous processes in mammalian cells, and the regulatory mechanisms of the cAMP pathway have been characterized. P. falciparum cAMP-dependent protein kinase plays an important role in the parasite's life cycle and thus represents an attractive target for the development of anti-malarial drugs. In this review, we focus on the P. falciparum cAMP/PKA pathway to provide new insights and an improved understanding of this signalling cascade.

Keywords

Plasmodium falciparummalariacAMP-dependent protein kinasePKAcAMP pathway
Type
Review Article
Information
Parasitology , Volume 138 , Issue 1 , January 2011 , pp. 1 - 25
Copyright
Copyright © Cambridge University Press 2010

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