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Breakdown of the blood-brain barrier in murine cerebral malaria

Published online by Cambridge University Press:  06 April 2009

C. M. Thumwood ,
N. H. Hunt ,
I. A. Clark  and
W. B. Cowden
C. M. Thumwood
Affiliation:
Department of Experimental Pathology, John Curtin School of Medical Research
N. H. Hunt
Affiliation:
Department of Experimental Pathology, John Curtin School of Medical Research
I. A. Clark
Affiliation:
Department of Zoology, The Faculties, Australian National University, P.O. Box 334, Canberra, ACT 2601, Australia
W. B. Cowden
Affiliation:
Department of Experimental Pathology, John Curtin School of Medical Research
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Summary

Cerebral malaria in A/J and CBA/H mice infected with Plasmodium berghei ANKA is accompanied by mononuclear cell infiltration, haemorrhage and cerebral endothelial cell damage. This damage is presumably one of the causes of the breakdown of the blood—brain barrier which was detected by measuring the movement of the dye Evans blue and radioisotope labelled albumin and erythrocytes. The density of brain tissue, measured by a Percoll gradient technique, was significantly reduced in mice exhibiting cerebral symptoms, suggesting the occurrence of cerebral oedema.

Type
Research Article
Information
Parasitology , Volume 96 , Issue 3 , June 1988 , pp. 579 - 589
Copyright
Copyright © Cambridge University Press 1988

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