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An overview on Leishmania (Mundinia) enriettii: biology, immunopathology, LRV and extracellular vesicles during the host–parasite interaction

Published online by Cambridge University Press:  10 December 2017

Larissa F. Paranaiba ,
Lucélia J. Pinheiro ,
Diego H. Macedo ,
Armando Menezes-Neto ,
Ana C. Torrecilhas ,
Wagner L. Tafuri  and
Rodrigo P. Soares
Larissa F. Paranaiba
Affiliation:
Departamento de Parasitologia, Universidade Federal de Minas Gerais – UFMG, Av. Antônio Carlos, 6627 – Pampulha, 31270-901, Belo Horizonte, Minas Gerais, Brazil
Lucélia J. Pinheiro
Affiliation:
Departamento de Patologia Geral, Universidade Federal de Minas Gerais – UFMG, Av Antônio Carlos, 6627 – Pampulha, 31270-901, Belo Horizonte, Minas Gerais, Brazil
Diego H. Macedo
Affiliation:
Centro de Pesquisas René Rachou/Fundação Oswaldo Cruz – CpqRR/FIOCRUZ, Av. Augusto de Lima, 1715 – Barro Preto, 30.190-009, Belo Horizonte, Minas Gerais, Brazil
Armando Menezes-Neto
Affiliation:
Centro de Pesquisas René Rachou/Fundação Oswaldo Cruz – CpqRR/FIOCRUZ, Av. Augusto de Lima, 1715 – Barro Preto, 30.190-009, Belo Horizonte, Minas Gerais, Brazil
Ana C. Torrecilhas
Affiliation:
Departamento de Farmácia, Universidade Federal de São Paulo – UNIFESP, Av. São Nicolau, 210, 09913-030, Diadema, São Paulo, Brazil
Wagner L. Tafuri
Affiliation:
Departamento de Patologia Geral, Universidade Federal de Minas Gerais – UFMG, Av Antônio Carlos, 6627 – Pampulha, 31270-901, Belo Horizonte, Minas Gerais, Brazil
Rodrigo P. Soares*
Affiliation:
Centro de Pesquisas René Rachou/Fundação Oswaldo Cruz – CpqRR/FIOCRUZ, Av. Augusto de Lima, 1715 – Barro Preto, 30.190-009, Belo Horizonte, Minas Gerais, Brazil
*
Author for correspondence: Rodrigo P. Soares, E-mail: [email protected]
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Abstract

One of the Leishmania species known to be non-infective to humans is Leishmania (Mundinia) enriettii whose vertebrate host is the guinea pig Cavia porcellus. It is a good model for cutaneous leishmaniasis, chemotherapeutic and molecular studies. In the last years, an increased interest has emerged concerning the L. (Mundinia) subgenus after the finding of Leishmania (M.) macropodum in Australia and with the description of other new/putative species such as L. (M.) martiniquensis and ‘L. (M.) siamensis’. This review focused on histopathology, glycoconjugates and innate immunity. The presence of Leishmania RNA virus and shedding of extracellular vesicles by the parasite were also evaluated.

Keywords

Leishmania (Mundinia) enriettiiL. (Mundinia) subgenusChemotherapyImmunopathologyInnate immunityGlycobiologyExtracellular vesiclesRNA virus
Type
Special Issue Review
Information
Parasitology , Volume 145 , Special Issue 10: Parasites and their (endo)symbiotic microbes , September 2018 , pp. 1265 - 1273
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Copyright © Cambridge University Press 2017 

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Footnotes

†

These authors contributed equally to this work.

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