Adult resistance to schistosomiasis mansoni: age-dependence of reinfection remains constant in communities with diverse exposure patterns

N. B. KABATEREINE; B. J. VENNERVALD; J. H. OUMA; J. KEMIJUMBI; A. E. BUTTERWORTH; D. W. DUNNE; A. J. C. FULFORD

doi:10.1017/S0031182098003576

Abstract

In a fishing community on Lake Albert in Uganda the pattern of intensity of Schistosoma mansoni infection 6 months after treatment with praziquantel was found to be very similar to reinfection patterns seen in previously studied endemic communities: the profile peaks sharply at around the age of 10 years falling away rapidly to much lower levels in adults. This is in stark contrast to the patterns of water contact, which differ greatly between fishing and non-fishing communities. On Lake Albert, adults appear to be more heavily exposed than children. From these observations we conclude that adults are physiologically (perhaps immunologically) more resistant to infection after treatment than children.

Crossref Citations

This article has been cited by the following publications. This list is generated based on data provided by Crossref.

De Clercq, D. Vercruysse, J. Picquet, M. Shaw, D. J. Diop, M. Ly, A. and Gryseels, B. 1999. The epidemiology of a recent focus of mixed Schistosoma haematobium and Schistosoma mansoni infections around the ‘Lac de Guiers’ in the Senegal River Basin, Senegal. Tropical Medicine & International Health, Vol. 4, Issue. 8, p. 544.

Useh, M. F. and Ejezie, G. C. 1999. Modification of behaviour and attitude in the control of schistosomiasis. 1. Observations on water-contact patterns and perception of infection. Annals of Tropical Medicine & Parasitology, Vol. 93, Issue. 7, p. 711.

Ross, A.G.P Sleigh, A.C Li, Y.S Williams, G.M Aligui, G.D.L and McManus, D.P 2000. Is there Immunity to Schistosoma japonicum?. Parasitology Today, Vol. 16, Issue. 4, p. 159.

Faulkner, Helen Gardon, Jacques Kamgno, Joseph Enyong, Peter Boussinesq, Michel and Bradley, Janette E. 2001. Antibody responses in onchocerciasis as a function of age and infection intensity. Parasite Immunology, Vol. 23, Issue. 9, p. 509.

Ross, Allen G. P. Sleigh, Adrian C. Li, Yuesheng Davis, George M. Williams, Gail M. Jiang, Zheng Feng, Zheng and McManus, Donald P. 2001. Schistosomiasis in the People's Republic of China: Prospects and Challenges for the 21st Century. Clinical Microbiology Reviews, Vol. 14, Issue. 2, p. 270.

Li, Yuesheng Sleigh, Adrian C. Ross, Allen G.P. Li, Yi Zhang, Xinyue Williams, Gail M. Yu, Xinling Tanner, Marcel and McManus, Donald P. 2001. Human susceptibility to Schistosoma japonicum in China correlates with antibody isotypes to native antigens. Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 95, Issue. 4, p. 441.

Al-Sherbiny, Maged Osman, Ahmed Barakat, Rashida El Morshedy, Hala Bergquist, Robert and Olds, Richard 2003. In vitro cellular and humoral responses to Schistosoma mansoni vaccine candidate antigens. Acta Tropica, Vol. 88, Issue. 2, p. 117.

DA’Dara, Akram A. Skelly, Patrick J. Walker, Christine M. and Harn, Donald A. 2003. A DNA‐prime/protein‐boost vaccination regimen enhances Th2 immune responses but not protection following Schistosoma mansoni infection. Parasite Immunology, Vol. 25, Issue. 8-9, p. 429.

Scott, J. T. Diakhaté, M. Vereecken, K. Fall, A. Diop, M. Ly, A. De Clercq, D. De Vlas, S. J. Berkvens, D. Kestens, L. and Gryseels, B. 2003. Human water contacts patterns in Schistosoma mansoni epidemic foci in northern Senegal change according to age, sex and place of residence, but are not related to intensity of infection. Tropical Medicine & International Health, Vol. 8, Issue. 2, p. 100.

Vennervald, Birgitte Jyding 2003. Encyclopedia of Life Sciences.

ABEBE, F. BIRKELAND, K. I. GAARDER, P. I. PETROS, B. and GUNDERSEN, S. G. 2003. The relationships between dehydroepiandrosterone sulphate (DHEAS), the intensity of Schistosoma mansoni infection and parasite‐specific antibody responses. APMIS, Vol. 111, Issue. 2, p. 319.

Naus, Cynthia W. A. Booth, Mark Jones, Frances M. Kemijumbi, Jovanice Vennervald, Birgitte J. Kariuki, Curtis H. Ouma, John H. Kabatereine, Narcis B. and Dunne, David W. 2003. The relationship between age, sex, egg‐count and specific antibody responses against Schistosoma mansoni antigens in a Ugandan fishing community. Tropical Medicine & International Health, Vol. 8, Issue. 6, p. 561.

Brake, David A. 2003. Parasites and Immune Responses: Memory Illusion?. DNA and Cell Biology, Vol. 22, Issue. 6, p. 405.

Fitzsimmons, Colin M. Joseph, Sarah Jones, Frances M. Reimert, Claus M. Hoffmann, Karl F. Kazibwe, Francis Kimani, Gachuhi Mwatha, Joseph K. Ouma, John H. Tukahebwa, Edridah M. Kariuki, Henry. C. Vennervald, Birgitte J. Kabatereine, Narcis B. and Dunne, David W. 2004. Chemotherapy for Schistosomiasis in Ugandan Fishermen: Treatment Can Cause a Rapid Increase in Interleukin-5 Levels in Plasma but Decreased Levels of Eosinophilia and Worm-Specific Immunoglobulin E. Infection and Immunity, Vol. 72, Issue. 7, p. 4023.

Kabatereine, N.B. Kemijumbi, J. Ouma, J.H. Kariuki, H.C. Richter, J. Kadzo, H. Madsen, H. Butterworth, A.E. Ørnbjerg, N. and Vennervald, B.J. 2004. Epidemiology and morbidity of Schistosoma mansoni infection in a fishing community along Lake Albert in Uganda. Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 98, Issue. 12, p. 711.

Kabatereine, Narcis B. Brooker, Simon Tukahebwa, Edridah M. Kazibwe, Francis and Onapa, Ambrose W. 2004. Epidemiology and geography of Schistosoma mansoni in Uganda: implications for planning control. Tropical Medicine & International Health, Vol. 9, Issue. 3, p. 372.

Joseph, Sarah Jones, Frances M. Kimani, Gachuhi Mwatha, Joseph K. Kamau, Timothy Kazibwe, Francis Kemijumbi, Jovanice Kabatereine, Narcis B. Booth, Mark Kariuki, Henry C. Ouma, John H. Vennervald, Birgitte J. and Dunne, David W. 2004. Cytokine Production in Whole Blood Cultures from a Fishing Community in an Area of High Endemicity forSchistosoma mansoniin Uganda: the Differential Effect of Parasite Worm and Egg Antigens. Infection and Immunity, Vol. 72, Issue. 2, p. 728.

Mentink-Kane, Margaret M. Cheever, Allen W. Thompson, Robert W. Hari, Danielle M. Kabatereine, Narcis B. Vennervald, Birgitte J. Ouma, John H. Mwatha, Joseph K. Jones, Frances M. Donaldson, Debra D. Grusby, Michael J. Dunne, David W. and Wynn, Thomas A. 2004. IL-13 receptor α 2 down-modulates granulomatous inflammation and prolongs host survival in schistosomiasis. Proceedings of the National Academy of Sciences, Vol. 101, Issue. 2, p. 586.

Booth, Mark Mwatha, Joseph K. Joseph, Sarah Jones, Frances M. Kadzo, Hilda Ireri, Edmund Kazibwe, Frances Kemijumbi, Jovanice Kariuki, Curtis Kimani, Gachuhi Ouma, John H. Kabatereine, Narcis B. Vennervald, Birgitte J. and Dunne, David W. 2004. Periportal Fibrosis in Human Schistosoma mansoni Infection Is Associated with Low IL-10, Low IFN-γ, High TNF-α, or Low RANTES, Depending on Age and Gender . The Journal of Immunology, Vol. 172, Issue. 2, p. 1295.

Booth, M Vennervald, B.J Kabatereine, N.B Kazibwe, F Ouma, J.H Kariuki, C.H Muchiri, E Kadzo, H Ireri, E Kimani, G Mwatha, J.K and Dunne, D.W 2004. Hepatosplenic morbidity in two neighbouring communities in Uganda with high levels of Schistosoma mansoni infection but very different durations of residence. Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 98, Issue. 2, p. 125.

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Adult resistance to schistosomiasis mansoni: age-dependence of reinfection remains constant in communities with diverse exposure patterns

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Adult resistance to schistosomiasis mansoni: age-dependence of reinfection remains constant in communities with diverse exposure patterns

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