Hostname: page-component-586b7cd67f-rdxmf Total loading time: 0 Render date: 2024-11-24T12:55:03.620Z Has data issue: false hasContentIssue false
  • English
  • Français

The Action of Ipecacuanha Alkaloids on Entamoeba histolytica and some other Entozoic Amoebae in Culture

Published online by Cambridge University Press:  06 April 2009

Clifford Dobell  and
P. P. Laidlaw
Clifford Dobell
Affiliation:
National Institute for Medical Research, London, N.W. 3.
P. P. Laidlaw
Affiliation:
National Institute for Medical Research, London, N.W. 3.
Get access Rights & Permissions [Opens in a new window]

Extract

It is now recognized, by all competent observers, that emetine is a specific therapeutic agent for the treatment of amoebic dysentery; but although it is known that a thorough course of emetine, in some form, will eradicate an infection with Entamoeba histolytica from most human beings, there is still complete ignorance as to how the cure is effected. The obvious hypothesis, that emetine is a specific poison for E. histolytica, has not hitherto been supported by adequate experimental evidence. It is true that observers have described experiments in which the alkaloid, in high dilution, has apparently killed various amoebae in vitro; but these experiments either ignored the peculiarly specific action of emetine in vivo on E. histolytica, or were carried out without adequate controls.

Type
Research Article
Information
Parasitology , Volume 18 , Issue 2 , June 1926 , pp. 206 - 223
Copyright
Copyright © Cambridge University Press 1926

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Boeck, W. C. and Drbohlav, J. (1925). The cultivation of Endamoeba histolytica. Amer Journ. Hyg. V. 371.Google Scholar
Carr, F. H. and Pyman, F. L. (1914). The alkaloids of ipecacuanha. Trans. Chem. Soc. CV. 1591.Google Scholar
Dale, H. H. (1915). A preliminary note on chronic poisoning by emetine. Brit. Med. Journ. II. 895.Google Scholar
Dale, H. H. and Dobell, C. (1917). Experiments on the therapeutics of amoebic dysentery. Journ. Pharmacol. and Exp. Therap. X. 399.Google Scholar
Dobell, C. (1919). The Amoebae living in Man. (London.)Google Scholar
Mattei, C. (1920). Toxicité, élimination urinaire et accumulation de l'émétine chez l'homme. Bull, et Mém. Soc. Méd. Hôp. Paris, XXXVI. 531.Google Scholar
Mayer, M. (1920). Klinische, morphologische und experimentelle Beobachtungen bei Amöbenerkrankungen. Arch. f. Schiffs u. Tropenhyg. XXIII. 177.Google Scholar
Pyman, F. L. (1917). The alkaloids of ipecacuanha. Part II. Trans. Chem. Soc. CXI. 419.Google Scholar
Pyman, F. L. (1918). Idem. Part III. Trans. Chem. Soc. CXIII. 222.Google Scholar
Sellards, A. W. and Leiva, L. (1923). Investigations concerning the treatment of amoebic dysentery. Philippine Journ. Sci. XXII. 1.Google Scholar