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Wine polyphenols and promotion of cardiac health

Published online by Cambridge University Press:  14 December 2007

Karen A. Cooper ,
Mridula Chopra  and
David I. Thurnham
Karen A. Cooper
Affiliation:
Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, County Londonderry BT55 1SA, UK
Mridula Chopra
Affiliation:
School of Pharmacy and Biomedical Sciences, IBBS, University of Portsmouth, Portsmouth PO1 2DT, UK
David I. Thurnham*
Affiliation:
Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, County Londonderry BT55 1SA, UK
*
*Corresponding author: Professor David I. Thurnham, fax +44 28 70 324965, email [email protected]
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Abstract

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Wine polyphenols are considered to have beneficial effects on CHD and atherosclerosis. The consumption of red wine is high in Italy and France, approximately four times greater than that in the UK. This disparity in red wine consumption is thought to be the reason for the ‘French paradox’, where France was shown to have a coronary mortality rate close to that of China or Japan despite saturated fat intakes and cholesterol levels similar to the UK and USA. In the present review, we discuss the effects of wine and some of its polyphenol constituents on early pathological indicators of CHD such as plasma lipids, the endothelium and vasculature, platelets and serum antioxidant activity. The review also examines whether the polyphenols or the alcohol in wine is responsible for the effects on markers of heart disease. The present review concludes that red wine polyphenols have little effect on plasma lipid concentrations but wine consumption appears to reduce the susceptibility of LDL to oxidation and increase serum antioxidant capacity. However, these effects do depend on the amount of wine and period of supplementation. Authors who have examined specific polyphenols suggest that some phenolics appear to have endothelium-dependent vaso-relaxing abilities and some a positive effect on NO concentrations. Red wine phenolics also have an inhibitory effect on platelet aggregation, and individual phenolics also have a similar effect in vitro, although it should be noted that there are often discrepancies as large as ten-fold between the concentrations of polyphenolics tested in vitro and their measured levels in vivo. Evidence suggests that alcohol has a positive synergistic effect with wine polyphenols on some atherosclerotic risk factors. Thus evidence that wine drinking is beneficial for cardiac health continues to accumulate but more research is required to understand fully and exactly the functions of red wine polyphenols.

Keywords

Wine polyphenolsCoronary heart diseaseAlcoholAntioxidants
Type
Research Article
Information
Nutrition Research Reviews , Volume 17 , Issue 1 , June 2004 , pp. 111 - 130
Copyright
Copyright © The Authors 2004

References

Adrian, M, Jeandet, P, Breuil, AC, Levite, D, Debord, S & Bessis, R (2000) Assay of resveratrol and derivative stilbenes in wines by direct injection high performance liquid chromatography. American Journal of Enology and Viticulture 51, 37–41.CrossRefGoogle Scholar
Andriambeloson, E, Kleshyov, AL, Muller, B, Beretz, A, Stoclet, J-C & Andriantsitohaina, R (1997) Nitric oxide production and endothelium-dependent vasorelaxation induced by wine polyphenols in rat aorta. British Journal of Pharmacology 120, 1053–1058.CrossRefGoogle ScholarPubMed
Andriambeloson, E, Magnier, C, Haan-Archipoff, G, Lobstein, A, Anton, R, Beretz, A, Stoclet, J-C & Andriantsitohaina, R (1998) Natural dietary polyphenolic compounds cause endothelial-dependent vasorelaxation in rat thoracic aorta. Journal of Nutrition 128, 2324–2333.CrossRefGoogle Scholar
Aviram, M (1996) Interaction of oxidised low density lipoprotein with macrophages in atherosclerosis, and the antiatherogenicity of antioxidants. European Journal of Clinical Chemistry and Clinical Biochemistry 34, 599–608.Google ScholarPubMed
Blache, D, Durand, P, Prost, M & Loreau, N (2002) (+)-Catechin inhibits platelet hyperactivity induced by an acute iron load in vivo. Free Radical Biology and Medicine 33, 1670–1680.CrossRefGoogle ScholarPubMed
Bors, W, Heller, W, Michel, C & Saran, M (1990) Flavonoids as antioxidants: determination of radical-scavenging efficiencies. Methods in Enzymology 186, 343–355.Google Scholar
Brand, K, Page, S, Rogler, G, Bartsch, A, Brandl, R, Knuechel, R, Page, M, Kaltschmidt, C, Baeuerle, PA & Neumeier, D (1996) Activated transcription factor nuclear factor-κB is present in atherosclerotic lesions. Journal of Clinical Investigation 97, 1715–1722.CrossRefGoogle Scholar
Bravo, L (1998) Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. Nutrition Reviews 56, 317–333.CrossRefGoogle ScholarPubMed
Cacetta, RA, Croft, KD, Beilin, LJ & Puddey, IB (2000) Ingestion of red wine significantly increases plasma phenolic acid concentrations but does not acutely affect ex vivo lipoprotein oxidisability. American Journal of Clinical Nutrition 71, 67–74.CrossRefGoogle Scholar
Cacetta, R, Burke, V, Mori, TA, Beilin, JL, Puttey, IB & Croft, KD (2001) Red wine polyphenols in the absence of alcohol reduce lipid peroxidative stress in smoking subjects. Free Radical Biology and Medicine 30, 636–642.CrossRefGoogle Scholar
Cao, G, Russell, RM, Lischner, N & Prior, RL (1998) Serum antioxidant capacity is increased by consumption of strawberries, spinach, red wine or vitamin C in elderly women. Journal of Nutrition 128, 2383–2390.CrossRefGoogle ScholarPubMed
Cao, G & Prior, RL (2000) Red wine in moderation: potential health benefits independent of alcohol. Nutrition in Clinical Care 3, 76–82.Google Scholar
Carbonneau, M-A, Léger, CL, Monnier, L, Michel, F, Fouret, G, Dedieu, F & Descomps, B (1997) Supplementation with wine phenolic compounds increases the antioxidant capacity of plasma and vitamin E of low-density lipoprotein without changing the lipoprotein Cu2+ -oxidisability: possible explanation by phenolic location. European Journal of Clinical Nutrition 51, 682–690.CrossRefGoogle ScholarPubMed
Carrero, P, Ortega, H, Martínez-Botas, J, Gómez-Coronado, D & Lasunción, MA (1998) Flavonoid-induced ability of minimally modified low-density lipoproteins to support lymphocyte proliferation. Biochemical Pharmacology 55, 1125–1129.CrossRefGoogle ScholarPubMed
Cestaro, B, Simonetti, P, Cervato, G, Brusamolino, A, Gatti, P & Testolin, G (1996) Red wine effects on peroxidation indexes of rat plasma and erythrocytes. International Journal of Food Sciences and Nutrition 47, 181–189.Google Scholar
Chai, Y-C, Binion, DG, Macklis, R & Chisholm, GM (2002) Smooth muscle cell proliferation induced by oxidised LDL-borne lysophosphatidylcholine: evidence for FGF-2 release from cells not extracellular matrix. Vascular Pharmacology 38, 229–237.Google Scholar
Chatenoud, L, Negri, E, La Vecchia, C, Volpato, O & Franceschi, S (2000) Wine drinking and diet in Italy. European Journal of Clinical Nutrition 54, 177–179.CrossRefGoogle ScholarPubMed
Chopra, M, Fitzsimmons, PEE, Strain, JJ, Thurnham, DI & Howard, AN (2000) Nonalcoholic red wine extract and quercetin inhibit LDL oxidation without affecting plasma antioxidant vitamin and carotenoid concentrations. Clinical Chemistry 46, 1162–1170.Google Scholar
Chopra, M & Thurnham, DI (1999) Antioxidants and lipoprotein metabolism. Proceedings of the Nutrition Society 58, 663–671.CrossRefGoogle ScholarPubMed
Chung, KT, Wong, TY, Wei, C-I & Huang, Y-W (1998) Tannins and human health: a review. Critical Reviews in Food Science and Nutrition 38, 421–464.Google Scholar
Cishek, MB, Galloway, MT, Karim, M, German, JB & Kappagoda, CT (1997) Effect of red wine on endothelium-dependent relaxation in rabbits. Clinical Science 93, 507–511.CrossRefGoogle ScholarPubMed
Cook, NC & Samman, S (1996) Flavonoids – chemistry, metabolism, cardioprotective effects and dietary sources. Nutritional Biochemistry 7, 66–76.Google Scholar
Crique, MH & Ringel, BL (1994) Does diet or alcohol explain the French paradox? Lancet 344, 1719–1723.Google Scholar
Cromheeke, KM, Kockx, MM, DeMeyer, GRY, Bosmans, JM, Bul, TH, Beelaerts, WJ, Vrints, CJ & Herman, AG (1999) Inducible nitric oxide synthase colocalizes with signs of lipid oxidation/peroxidation in human atherosclerotic plaques. Cardiology Research 43, 744–754.Google Scholar
Cuevas, AM, Guasch, V, Castillo, O, Irribarra, V, Mizon, C, San Martin, A, Strobel, P, Perez, D, Germain, AM & Leighton, F (2000) A high-fat diet induces and red wine counteracts endothelial dysfunction in human volunteers. Lipids 35, 143–148.CrossRefGoogle ScholarPubMed
Day, AJ, Bao, Y, Morgan, MRA & Williamson, G (2000) Conjugation position of quercetin glucuronides and effect on biological activity. Free Radical Biology and Medicine 29, 1234–1243.CrossRefGoogle ScholarPubMed
Day, AMP, Kemp, HJ, Bolton, C, Hertog, M & Stansbie, D (1997) Effect of concentrated red grape juice consumption on serum antioxidant capacity and low density lipoprotein oxidation. Annals of Nutrition and Metabolism 41, 353–357.Google Scholar
Deckert, V, Desrumaux, C, Athias, A, Duverneuil, L, Palleau, V, Gambert, P, Masson, D & Lagrost, L (2002) Prevention of LDL [alpha]-tocopherol consumption, cholesterol oxidation, and vascular endothelium dysfunction by polyphenolic compounds from red wine. Atherosclerosis 165, 41–50.CrossRefGoogle ScholarPubMed
Demrow, HS, Slane, PR & Folts, JD (1995) Administration of wine and grape juice inhibits in vivo platelet activity and thrombosis in stenosed canine coronary arteries. Circulation 91, 1182–1188.CrossRefGoogle ScholarPubMed
de Pascual-Teresa, S, Rivas-Gonzalo, JC & Santos-Buelga, C (2000) Prodelphinidins and related flavanols in wine. International Journal of Food Sciences and Nutrition 35, 33–40.Google Scholar
de Rijke, YB, Demacker, PNM, Assen, NA, Sloots, LM, Katan, MB & Stalenhoef, AFH (1996) Red wine consumption does not affect oxidisability of low density lipoproteins in volunteers. American Journal of Clinical Nutrition 63, 329–334.Google Scholar
Di Bari, M, Zacchei, S, Kritchevsky, SB, Anichini, M, Cesaretti, S, Chiarlone, M, Masotti, G & Marchionni, N (2003) Anti-oxidized LDL antibodies and wine consumption: a population-based epidemiological study in Dicomano, Italy. Annals of Epidemiology 13, 189–195.Google Scholar
Ector, BJ, Magee, JB, Hegwood, CP & Coign, MJ (1996) Resveratrol concentration in muscadine berries, juice, pomace, purees, seeds and wines. American Journal of Enology and Viticulture 47, 57–62.CrossRefGoogle Scholar
Estruch, R (2000) Wine and cardiovascular disease. Food Research International 33, 219–226.Google Scholar
Francia-Aricha, EM, Gerra, MT, Rivas-Gonzalo, JC & Santos-Buelga, C (1997) New anthocyanin pigments formed after condensation with flavanols. Journal of Agricultural and Food Chemistry 45, 2262–2266.CrossRefGoogle Scholar
Frankel, EN, Kanner, J, German, JB, Parks, E & Kinsella, JE (1993) Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet 341, 454–457.Google Scholar
Fuhrman, B, Lavy, A & Aviram, M (1995) Consumption of red wine with meals reduces the susceptibility of human plasma and low density lipoprotein to lipid peroxidation. American Journal of Clinical Nutrition 61, 549–554.Google Scholar
Goldberg, DM, Garovic-Kocic, V, Diamandis, EP & Pace-Asciak, CR (1996) Wine: does the colour count? Clinica Chimica Acta 246, 183–193.Google Scholar
Goldberg, DM, Hahn, SE & Parkes, JG (1995 a) Beyond alcohol: beverage consumption and cardiovascular mortality. Clinica Chimica Acta 237, 155–187.CrossRefGoogle ScholarPubMed
Goldberg, DM, Karumanchiri, A, Tsang, E & Soleas, GL (1998) Catechin and epicatechin concentrations of red wines: regional and cultivar-related differences. American Journal of Enology and Viticulture 49, 23–34.Google Scholar
Goldberg, DM, Yan, J, Ng, E, Diamandis, EP, Karumanchiri, A, Soleas, GL & Waterhouse, AL (1995 b) A global survey of trans-resveratrol concentrations in commercial wines. American Journal of Enology and Viticulture 46, 159–165.Google Scholar
Graham, A, Hogg, N, Kalyanaraman, B, O'Leary, V, Darley-Usmar, V & Moncada, S (1993) Peroxynitrite modification of low-density lipoprotein leads to recognition by the macrophage scavenger receptor. FEBS Letters 330, 181–185.Google Scholar
Han, J, Hajjar, DP, Tauras, JM & Nicholson, AC (1999) Cellular cholesterol regulates expression of the macrophage type B scavenger receptor, CD36. Journal of Lipid Research 40, 830–838.CrossRefGoogle ScholarPubMed
Harbourne, J (1994) The Flavonoids: Advances in Research Since 1986. London: Chapman & Hall.Google Scholar
Harbourne, J (2000) Chemistry of the flavonoid pigments. In Wake up to Flavonoids, pp. 3–12 [Rice-Evans, C editor]. London: Royal Society of Medicine Press Ltd.Google Scholar
Harbourne, J & Williams, C (2000) Advances in flavonoid research since 1992. Phytochemistry 55, 481–504.Google Scholar
Hayek, T, Fuhrman, B, Vaya, J, Rosenblat, M, Belinky, P, Coleman, R, Elis, A & Aviram, M (1997) Reduced progression of atherosclerosis in apolipoprotein E-deficient mice following consumption of red wine, or its polyphenols quercetin or catechin, is associated with reduced susceptibility of LDL to oxidation and aggregation. Arteriosclerosis, Thrombosis, and Vascular Biology 17, 2744–2752.Google Scholar
Hazen, SL, Zhang, R, Shen, Z, Wu, W, Podrez, EA, MacPherson, JC, Schmitt, D, Mitra, SN, Mukhopadhyay, C, Chen, Y, Cohen, PA, Hoff, HF & Abu-Soud, HM (1999) Formation of nitric oxide-derived oxidants by myeloperoxidase in monocytes. Pathways for monocyte-mediated protein nitration and lipid peroxidation in vivo. Circulation Research 85, 950–958.Google Scholar
Hertog, MGL, Hollman, PCH & van de Putte, B (1993) Content of potentially anti-carcinogenic flavonoids of tea infusions, wines and fruit juices. Journal of Agricultural and Food Chemistry 41, 1242–1246.Google Scholar
Hollman, PCH (1997) Bioavailability of flavonoids. European Journal of Clinical Nutrition 51, S66–S69.Google Scholar
Hollman, PCH & Arts, ICW (2000) Flavonols, flavones and flavanols – nature, occurrence and dietary burden. Journal of the Science of Food and Agriculture 80, 1081–1093.Google Scholar
Husain, SR, Cillard, J & Cillard, P (1987) Hydroxyl radical scavenging activity of flavonoids. Phytochemistry 26, 2489–2491.Google Scholar
Iijima, K, Yoshizumi, M, Hashimoto, M, Kim, S, Eto, M, Ako, J, Liang, Y-Q, Sudoh, N, Hosoda, K, Nakahara, K, Toba, K & Ouchi, Y (2000) Red wine polyphenols inhibit proliferation of vascular smooth muscle cells and downregulate expression of Cyclin A gene. Circulation 101, 805–811.Google Scholar
Iijima, K, Yoshizumi, M & Ouchi, Y (2002) Effect of red wine polyphenols on vascular smooth muscle cell function – molecular mechanism of the [French paradox]. Mechanisms of Ageing and Development 123, 1033–1039.Google Scholar
Jackson, RS (1994) Wine Science: Principles and Applications. London: Academic Press Inc.Google Scholar
Janssen, PLTMK, Katan, MB, Hollman, PCH & Venema, DP (1994) No aspirin in red wine. Lancet 344 762.Google Scholar
Janssen, PLTMK, Mensink, RP, Cox, FJJ, Harryvan, JL, Hovenier, R, Hollman, PCH & Katan, MB (1998) Effects of the flavonoids quercetin and apigenin on hemostasis in healthy volunteers: results from an in vitro and a dietary supplement study. American Journal of Clinical Nutrition 67, 255–262.Google Scholar
Jeandet, P, Bessis, R, Maume, BF & Sbaghi, M (1993) Analysis of resveratrol in burgundy wines. Journal of Wine Research 4, 79–85.Google Scholar
Jeandet, P, Bessis, R, Sbaghi, M, Meunier, P & Trollat, P (1995) Resveratrol content of wines of different ages: relationship with fungal disease pressure in the vineyard. American Journal of Enology and Viticulture 46, 1–4.Google Scholar
Klurfeld, DM & Kritchevsky, D (1981) Differential effects of alcoholic beverages on experimental atherosclerosis in rabbits. Experimental Molecular Pathology 34, 62–71.CrossRefGoogle ScholarPubMed
Koga, T & Meydani, M (2001) Effect of plasma metabolites of (+)-catechin and quercetin on monocyte adhesion to human aortic endothelial cells. American Journal of Clinical Nutrition 73, 941–948.CrossRefGoogle ScholarPubMed
Kondo, K, Matsumoto, A, Kurata, H, Tanahashi, H, Koda, H, Amachi, T & Itakura, H (1994) Inhibition of oxidation of low density lipoprotein with red wine. Lancet 344 1152.Google Scholar
Kushi, LH, Lenart, EB & Willett, WC (1995) Health implications of Mediterranean diets in light of contemporary knowledge. 2. Meat, wine, fats and oils. American Journal of Clinical Nutrition 61, 1416S–1427S.Google Scholar
Lamuela-Raventós, RM, Romero-Pérez, AI, Waterhouse, AL & de la Torre-Boronat, MC (1995) Direct HPLC analysis of cis- and trans-resveratrol and piceid isomers in Spanish red Vitis vinifera wines. Journal of Agricultural and Food Chemistry 43, 281–283.Google Scholar
Lamuela-Raventós, RM & Waterhouse, AL (1993) Occurrence of resveratrol in selected Californian wines by a new HPLC method. Journal of Agriculture and Food Chemistry 41, 521–523.Google Scholar
Landolfi, R, Mower, RL & Steiner, M (1984) Modification of platelet function and arachidonic acid metabolism by bioflavonoids. Biochemical Pharmacology 33, 1525–1530.Google Scholar
Lanningham-Foster, L, Chen, C, Chance, DS & Loo, G (1995) Grape extract inhibits lipid peroxidation of human LDL. Biological and Pharmaceutical Bulletin 18, 1347–1351.Google Scholar
Lavy, A, Fuhrman, B, Markel, A, Dankner, G, Ben-Amotz, A, Presser, D & Aviram, M (1994) Effect of dietary supplementation of red or white wine on human blood chemistry, haematology and coagulation: favourable effect of red wine on plasma high-density lipoprotein. Annals of Nutrition and Metabolism 38, 287–294.CrossRefGoogle ScholarPubMed
Law, M & Wald, N (1999) Why heart disease mortality is low in France: the time lag explanation. British Medical Journal 318, 1471–1480.Google Scholar
Li, TK, Yin, SJ, Crabb, DW, O'Connor, S & Ramchandani, VA (2001) Genetic and environmental influences on alcohol metabolism in humans. Alcoholism, Clinical and Experimental Research 21, 136–144.Google Scholar
Liu, XQ, Buchanan, W, Mathews, AJ, Chung, BH & Bagdale, JD (1997) Lack of effect of vitamin E on cholesterol ester transfer and lipoprotein composition on cholesterol fed rabbits. Comparative Biochemistry and Physiology 117B, 553–559.CrossRefGoogle Scholar
Liu, Y & Liu, G (2004) Isorhaptontigenin and resveratrol suppress oxLDL-induced proliferation and activation of ERK1/2 mitogen-activated protein kinases of bovine aortic smooth muscle cells. Biochemical Pharmacology 15, 777–785.CrossRefGoogle Scholar
McCaffrey, TA (2000) TGF-βs and TGF-β receptors in atherosclerosis. Cytokine and Growth Factor Reviews 11, 103–114.CrossRefGoogle ScholarPubMed
McElduff, P & Dobson, AJ (1997) How much alcohol and how often? Population based case-control study of alcohol consumption and risk of a major coronary event. British Medical Journal 314, 1159–1164.CrossRefGoogle ScholarPubMed
Mangiapane, EH & Salter, A (1999) Diet, Lipoproteins and Coronary Heart Disease. A Biochemical Perspective. Nottingham: Nottingham University Press.Google Scholar
Martens, JS, Lougheed, M, Gomez-Munoz, A & Steinbrecher, UP (1999) A modification of apolipoprotein B accounts for most of induction of macrophage growth by oxidised low-density lipoprotein. Journal of Biological Chemistry 274, 10903–10910.Google Scholar
Maziere, C, Alimardani, G, Dantin, F, Conte, MA & Maziere, JC (1999) Oxidised LDL activates signal transducers and activators of transcription 1 and signal transducers and activators of transcription 3 transcription factors: possible involvement of reactive oxygen species. FEBS Letters 448, 49–52.Google Scholar
Middleton, E & Kandaswami, C (1995) The impact of plant flavonoids on mammalian biology: implications for immunity, inflammation and cancer. In The Flavonoids: Advances in Research Since 1986, pp. 619–652 [Harbourne, J editor]. London: Chapman & Hall.Google Scholar
Nestle, M (1995) Mediterranean diets: historical and research overview. American Journal of Clinical Nutrition 61, 1313S–1320S.Google Scholar
Nigdikar, SV & Howard, AN (1997 a) Antioxidant activity of red wine polyphenols in vivo. Atherosclerosis 134, 203 Abstr.Google Scholar
Nigdikar, SV & Howard, AN (1997 b) Red wine polyphenols increase plasma total TGF-β. Atherosclerosis 1–2, 275 Abstr.Google Scholar
Nigdikar, SV, Williams, NR, Griffin, BA & Howard, AN (1998) Consumption of red wine polyphenols reduces the susceptibility of low-density lipoproteins to oxidation in vivo. American Journal of Clinical Nutrition 68, 258–265.CrossRefGoogle ScholarPubMed
Okuda, T & Yokotsuma, K (1996) Trans-resveratrol concentrations in berry skins and wines from grapes grown in Japan. American Journal of Enology and Viticulture 47, 93–99.CrossRefGoogle Scholar
Pace-Asciak, CR, Rounova, O, Hahn, SE, Diamandis, EP & Goldberg, DM (1996) Wines and grape juices as modulators of platelet aggregation in healthy human subjects. Clinica Chimica Acta 246, 163–182.Google Scholar
Parhami, F, Fang, ZT, Fogelman, AM, Andalibi, A, Territo, MC & Berliner, JA (1993) Minimally modified low density lipoprotein-induced inflammatory responses in endothelial cells are mediated by cyclic adenosine monophosphate. Journal of Clinical Investigation 92, 471–478.Google Scholar
Parr, AJ & Bolwell, GP (2000) Phenols in the plant and in man. The potential for possible nutritional enhancement of the diet by modifying the phenols content or profile. Journal of the Science of Food and Agriculture 80, 985–1012.Google Scholar
Pezet, R, Pont, V & Cuenet, P (1994) Method to determine resveratrol and pterostilbene in grape berries and wines using high-performance liquid chromatography and highly sensitive fluorimetric detection. Journal of Chromatography 663, 191–197.Google Scholar
Pignatelli, P, Pulcinelli, FM, Celestini, A, Lenti, L, Ghiselli, A, Gazzaniga, PP & Violi, F (2000) The flavonoids quercetin and catechin synergistically inhibit platelet function by antagonising the intracellular production of hydrogen peroxide. American Journal of Clinical Nutrition 72, 1150–1155.Google Scholar
Plumb, GW, de Pascual-Teresa, S, Santos-Buelga, C, Cheynier, V & Williamson, G (2000) Antioxidant properties of catechins and proanthocyanidins: effect of polymerisation, galloylation and glycosylation. Free Radical Biology and Medicine 29, 351–358.Google Scholar
Podrez, EA, Schmitt, D, Hoff, HF & Hazen, SL (1999) Myelopreoxidase-generated reactive nitrogen species convert LDL into an atherogenic form in vitro. Journal of Clinical Investigation 103, 1547–1560.Google Scholar
Prasad, K & Kalra, J (1993) Oxygen free radicals and hypercholesterolaemic atherosclerosis – effect of vitamin E. American Heart Journal 125, 958–973.Google Scholar
Renaud, S, Beswick, AD, Fehily, AM, Sharp, DS & Elwood, PC (1992) Alcohol and platelet aggregation: the Caerphilly Prospective Heart Disease Study. American Journal of Clinical Nutrition 55, 1012–1017.Google Scholar
Renaud, S & de Lorgeril, M (1992) Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet 339, 1523–1526.Google Scholar
Rendig, SV, Symons, D, Longhurst, JC & Amsterdam, EA (2000) Effects of red wine, alcohol, and the red wine flavonoid, quercetin, on isolated coronary resistance and conductance arteries. Journal of the American College of Cardiology 35, 245A.Google Scholar
Rice-Evans, C & Miller, NJ (1996) Antioxidant activities of flavonoids as bioactive components of food. Biochemical Society Transactions 24, 790–795.CrossRefGoogle ScholarPubMed
Rifici, VA, Stephan, EM, Schneider, SH & Khachadurian, AK (1999) Red wine inhibits the cell-mediated oxidation of LDL and HDL. Journal of the American College of Nutrition 18, 137–143.Google Scholar
Rimm, EB, Klatsky, AL, Grobbee, D & Stampfer, MJ (1996) Review of moderate alcohol consumption and reduced risk of coronary heart disease: is the effect due to beer, wine, or spirits? British Medical Journal 312 731.Google Scholar
Ruf, JC, Berger, JL & Renaud, S (1995) Platelet rebound effect of alcohol withdrawal and wine drinking in rats. Arteriosclerosis, Thrombosis and Vascular Biology 15, 140–144.Google Scholar
Santos-Buelga, C & Scalbert, A (2000) Proanthocyanidins and tannin-like compounds – nature, occurrence, dietary intake and effects on nutrition and health. Journal of the Science of Food and Agriculture 80, 1094–1117.Google Scholar
Saucier, C, Guerra, C, Pianet, I, Laguerre, M & Glories, Y (1997) (+)-Catechin-acetaldehyde condensation products in relation to wine-ageing. Phytochemistry 46, 229–234.Google Scholar
Seigneur, M, Bonnet, J, Dorian, B, Benchimol, D, Drouillet, F, Gouverneur, G, Larrue, J, Crockett, R, Boisseau, M-R, Ribereau-Gayon, P & Bricaud, H (1990) Effect of the consumption of alcohol, white wine and red wine on platelet function and serum lipids. Journal of Applied Cardiology 5, 215–222.Google Scholar
Serafini, M, Maiani, G & Ferro-Luzzi, A (1998) Alcohol-free red wine enhances plasma antioxidant capacity in humans. Journal of Nutrition 128, 1003–1007.Google Scholar
Sharpe, PC, McGrath, LT, McClean, E, Young, IS & Archbold, GPR (1995) Effect of red wine consumption on lipoprotein (a) and other risk factors for atherosclerosis. Quarterly Journal of Medicine 88, 101–108.Google ScholarPubMed
Shen, GX, Noval, C & Angel, A (1996) Effect of dietary vitamin E supplementation on cholesterol ester transfer activity in hamster adipose tissue. Atherosclerosis 124, 211–219.CrossRefGoogle ScholarPubMed
Shimoi, K, Saka, N, Kaji, K, Nozawa, R & Kinae, N (2000) Metabolic fate of luteolin and its functional activity at focal site. Biofactors 12, 181–186.CrossRefGoogle ScholarPubMed
Singh, GK & Hoyert, DL (2000) Social epidemiology of chronic liver disease and cirrhosis mortality in the United States, 1935–1997: trends and differentials by ethnicity, socioeconomic status, and alcohol consumption. Human Biology 72, 801–820.Google ScholarPubMed
Singleton, VL (1982) Grape and wine phenolics; background and prospects. In Grape and Wine Centennial Symposium, Proceedings of the University of California, Davis, pp. 215–227 [Webb, AD editor]. Davis CA: University of California Press.Google Scholar
Singleton, VL & Rossi, JA (1965) Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. American Journal of Enology and Viticulture 16, 144–158.Google Scholar
Soleas, GL, Diamandis, EP & Goldberg, DM (1997 a) Wine as a biological fluid: history, production, and role in disease prevention. Journal of Clinical Laboratory Analysis 11, 287–313.3.0.CO;2-4>CrossRefGoogle ScholarPubMed
Soleas, GL, Goldberg, DM, Diamandis, EP, Karumanchiri, A, Yan, J & Ng, E (1995) A derivatised gas chromatographic-mass spectrometric method for the analysis of both isomers of resveratrol in juice and wine. American Journal of Enology and Viticulture 46, 346–352.Google Scholar
Soleas, GL, Tomlinson, G, Diamandis, EP & Goldberg, DM (1997 b) Relative contributions of polyphenolic constituents to the antioxidant status of wines: development of a predictive model. Journal of Agricultural and Food Chemistry 45, 3995–4003.Google Scholar
St Leger, AS, Cochrane, AL & Moore, F (1979) Factors associated with cardiac mortality in developed countries with particular reference to the consumption of wine. Lancet i, 1017–1020.Google Scholar
Sugiyama, A, Saitoh, M, Takahara, A, Satoh, Y & Hashimoto, K (2003) Acute cardiovascular effects of a new beverage made of wine vinegar and grape juice, assessed using an in vivo rat. Nutrition Research 23, 1291–1296.Google Scholar
Sun, GY, Xia, J, Xu, J, Allenbrand, B, Simonyi, A, Rudeen, PK & Sun, AY (1999) Dietary supplementation of grape polyphenols to rats ameliorates chronic ethanol-induced changes in hepatic morphology without altering changes in hepatic liquids. Journal of Nutrition 129, 1814–1819.Google Scholar
Suzuki, A, Kagawa, D, Fujii, A, Ochiai, R, Tokimitsu, I & Saito, I (2002) Short- and long-term effects of ferulic acid on blood pressure in spontaneously hypertensive rats. American Journal of Hypertension 15, 351–357.Google Scholar
Tedesco, I, Russo, M, Russo, P, Iacomino, G, Russo, GL, Carraturo, A, Faruolo, C, Moio, L & Palumbo, R (2000) Antioxidant effect of red wine polyphenols on red blood cells. Journal of Nutritional Biochemistry 11, 114–119.Google Scholar
Teissedre, P-L, Frankel, EN, Waterhouse, AL, Peleg, H & German, JB (1996) Inhibition of in vitro LDL oxidation by phenolic antioxidants from grapes and wines. Journal of the Science of Food and Agriculture 70, 55–61.Google Scholar
The Wine Institute (1999) Per capita wine consumption by country in liters and gallons per capita. www.wineinstitute.orgGoogle Scholar
Thurnham, DI, Davies, JA, Crump, BJ, Situnayake, RD & Davis, M (1986) The use of different lipids to express serum tocopherol:lipid ratios for the measurement of vitamin E status. Annals of Clinical Biochemistry 23, 514–520.Google Scholar
Tjønneland, A, Grønbæk, M, Stripp, C & Overvad, K (1999) Wine intake and diet in a random sample of 48,763 Danish men and women. American Journal of Clinical Nutrition 69, 49–54.Google Scholar
Trichopoulou, A, Kouris-Blazos, A, Vassilakou, T, Gnardellis, C, Polychronopoulos, E, Venizelos, M, Lagiou, P, Wahlqvist, ML & Trichopoulos, D (1995) Diet and survival of elderly Greeks: a link to the past. American Journal of Clinical Nutrition 61, 1346S–1350S.Google Scholar
Tsimikas, S, Palinski, W & Witztum, JL (2001) Circulating autoantibodies to oxidised LDL correlate with arterial accumulation and depletion of oxidised LDL in LDL receptor-deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology 21, 95–100.Google Scholar
UK Trade and Investment (2004) Food and Drink Market in France. www.uktradeinvest.gov.uk/food/france/profile/ overview.shtmlGoogle Scholar
Ursini, F, Tubaro, F, Rong, J & Sevanian, A (1999) Optimisation of nutrition: polyphenols and vascular protection. Nutrition Reviews 57, 241–249.CrossRefGoogle Scholar
van Der Gaag, MS, van Tol, A, Vermunt, SH, Scheek, LM, Schaafsma, G & Hendriks, HFJ (2001) Alcohol consumption stimulates early steps in reverse cholesterol transport. Journal of Lipid Research 42, 2077–2083.Google Scholar
Viana, M, Barbas, C, Bonet, B, Bonet, MV, Castro, M, Fraile, V & Herrera, E (1996) In vitro effects of a flavonoid-rich extract on LDL oxidation. Atherosclerosis 123, 83–91.Google Scholar
Vinson, JA, Teufel, K & Wu, N (2001) Red wine, dealcoholized red wine, and especially grape juice, inhibit atherosclerosis in a hamster model. Atherosclerosis 156, 67–72.Google Scholar
Virgili, F, Kobuchi, H & Packer, L (1998) Nitrogen monoxide (NO) metabolism: antioxidant properties and modulation of inducible NO synthase activity in activated macrophages by procyanidins extracted from Pinus maritima (Pycnogenol®). In Flavonoids in Health and Disease, pp. 421–436 [Rice-Evans, C and Packer, L editors]. New York: Marcel Dekker Inc.Google Scholar
Vogel, RA (2003) Vintners and vasodilators: are French red wines more cardioprotective? Journal of the American College of Cardiology 41, 479–481.CrossRefGoogle ScholarPubMed
Von Wartburg, J-P, Buhler, R, Maring, J-A & Pestalozzi, D (1983) The polymorphisms of alcohol and aldehyde dehydrogenase and their significance for acetaldehyde toxicity. Pharmacology Biochemistry and Behavior 18, 123–125.Google Scholar
Wallerath, T, Poleo, D, Li, H & Forstermann, U (2003) Red wine increases the expression of human endothelial nitric oxide synthase: a mechanism that may contribute to its beneficial cardiovascular effects. Journal of the American College of Cardiology 41, 471–478.Google Scholar
Waterhouse, AL & Walzem, RL (1998) Nutrition of grape phenolics. In Flavonoids in Health and Disease, pp. 359–385 [Rice-Evans, C and Packer, L editors]. New York: Marcel Dekker Inc.Google Scholar
Whitehead, TP, Robinson, D, Allaway, S, Syms, J & Hale, A (1995) Effect of red wine ingestion on the antioxidant capacity of serum. Clinical Chemistry 41, 32–35.CrossRefGoogle ScholarPubMed
Willett, WC, Sacks, F, Trichopoulou, A, Drescher, GFerro-Luzzi, A, Helsing, E & Trichopoulos, D (1995) Mediterranean diet pyramid: a cultural model for healthy eating. American Journal of Clinical Nutrition 61, 1402S–1406S.Google Scholar
Wippel, R, Rehn, M, Gorren, ACF, Schmidt, K & Mayer, B (2004) Interference of the polyphenol epicatechin with the biological chemistry of nitric oxide- and peroxynitrite-mediated reactions. Biochemical Pharmacology 67, 1285–1295.Google Scholar
Witztum, JL & Steinberg, D (2001) The oxidative modification hypothesis of atherosclerosis: does it hold for humans? Trends in Cardiovascular Medicine 11, 93–102.Google Scholar
World Health Organization (1989) The WHO MONICA Project. A worldwide monitoring system for cardiovascular diseases: cardiovascular mortality and risk factors in selected communities. In World Health Statistics A, pp. 27–149. Geneva: WHO.Google Scholar
Zhang, Q-H, Das, K, Siddiqui, S & Myers, AK (2000) Effects of acute, moderate ethanol consumption on human platelet aggregation in platelet-rich plasma and whole blood. Alcoholism, Clinical and Experimental Research 24, 528–534.Google Scholar
Zhu, Q-Y, Huang, Y & Chen, Z-Y (2000) Interaction between flavonoids and α-tocopherol in human low density lipoprotein. Journal of Nutritional Biochemistry 11, 14–21.Google Scholar