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Nutritional Implications of Gastrointestinal and Liver Metabolism in Ruminants

Published online by Cambridge University Press:  14 December 2007

C. J. Seal
Affiliation:
Department of Biological and Nutritional Sciences, Faculty of Agriculture and Biological Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne NE1 7RU
C. K. Reynolds
Affiliation:
Ruminant Nutrition Laboratory, Livestock and Poultry Sciences Institute, USDA Agricultural Research Service, Beltsville MD 20705, USA Department of Agriculture, University of Reading, Earley Gate, PO Box 236. Reading RG6 2AT.
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Abstract

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Type
Research Article
Copyright
Copyright © The Nutrition Society 1993

References

REFERENCES

Aiello, R. J., Armentano, L. E., Bertics, S. J. & Murphy, A. T. (1989). Volatile fatty acid uptake and propionate metabolism in ruminant hepatocytes. Journal of Dairy Science 72, 942949.CrossRefGoogle ScholarPubMed
Armentano, L. E. (1992). Ruminant hepatic metabolism of volatile fatty acids, lactate and pyruvate. Journal of Nutrition 122, 838842.CrossRefGoogle ScholarPubMed
Armstrong, D. G. & Smithard, R. R. (1979). The fate of carbohydrates in the small and large intestines of the ruminant. Proceedings of the Nutrition Society 38, 283294.CrossRefGoogle ScholarPubMed
Baird, G. D., Lomax, M. A., Symonds, H. W. & Shaw, S. R. (1980). Net hepatic and splanchnic metabolism of lactate, pyruvate and propionate in dairy cows in vivo in relation to lactation and nutrient supply. Biochemical Journal 186, 4757.CrossRefGoogle ScholarPubMed
Balcells, J, Seal, C. J. & Parker, D. S. (1992). Effect of intravenous glucose infusion on glucose metabolism by portal drained viscera of sheep fed a low quality roughage. Journal of Animal Science 70 (Suppl. 1), 294.Google Scholar
Baldwin, R. L. & Jesse, B. W. (1992). Developmental changes in glucose and butyrate metabolism by isolated sheep ruminal cells. Journal of Nutrition 122, 11491153.CrossRefGoogle ScholarPubMed
Baldwin, R. L. & Jesse, B. W. (1993). Metabolic interaction of propionate with ketone production by isolated rumen epithelial cells. Journal of Animal Science 71 (Suppl. 1), 270.Google Scholar
Baracos, V. E., Brun-Bellut, J. & Marie, M. (1991). Tissue protein synthesis in lactating and dry goats. British Journal of Nutrition 66, 451465.CrossRefGoogle ScholarPubMed
Bell, A. W. (1979). Lipid metabolism in liver and selected tissues and in the whole body of ruminant animals. Progress in Lipid Research 18, 117164.CrossRefGoogle ScholarPubMed
Bergman, E. N. (1975). Production and utilization of metabolites by the alimentary tract as measured in portal and hepatic blood. In Digestion and Metabolism in the Ruminant, pp. 292305 [McDonald, I. W. & Warner, A. C. I., editors]. Armidale, Australia: University of New England Publishing Unit.Google Scholar
Bergman, E. N. (1989). Splanchnic and peripheral uptake of amino acids in relation to the gut. Federation Proceedings 45, 22772282.Google Scholar
Bergman, E. N. (1990). Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. Physiological Reviews 70, 567590.CrossRefGoogle ScholarPubMed
Bergman, E. N. & Heitmann, R. N. (1978). Metabolism of amino acids by the gut, liver, kidneys and peripheral tissues. Federation Proceedings 37, 12281232.Google ScholarPubMed
Bergman, E. N., Katz, M. L. & Kaufman, C. F. (1970). Quantitative aspects of hepatic and portal glucose metabolism and turnover in sheep. American Journal of Physiology 219, 785793.CrossRefGoogle ScholarPubMed
Bergman, E. N. & Pell, J. M. (1984). Integration of amino acid metabolism in the ruminant. In Herbivore Nutrition in the Subtropics and Tropics, pp. 613628 [Gilchrist, F. M. C. & MacKie, R. I., editors]. Craighall, Johannesburg, South Africa: Science Press.Google Scholar
Bergman, E. N. & Wolff, J. E. (1971). Metabolism of volatile fatty acids by liver and portal drained viscera in sheep. American Journal of Physiology 221, 586592.CrossRefGoogle ScholarPubMed
Bradley, S. E., Ingelfinger, F. J., Bradley, C. P. & Curry, J. J. (1945). The estimation of hepatic blood flow in man. Journal of Clinical Investigation 24, 890897.CrossRefGoogle ScholarPubMed
Brown, G. F., Armstrong, D. G. & MacRae, J. C. (1968). The establishment in one operation of a cannula into the rumen and re-entrant cannulae into the duodenum and ileum of the sheep. British Veterinary Journal 124, 7882.CrossRefGoogle ScholarPubMed
Burrin, D. G., Ferrell, C. L., Eisemann, J. H., Britton, R. A. & Nienaber, J. A. (1989). Effect of level of nutrition on splanchnic blood flow and oxygen consumption in sheep. British Journal of Nutrition 62, 2334.CrossRefGoogle ScholarPubMed
Campbell, R. M. & Fell, B. F. (1970). Observations on hypertrophy of the liver in breeding ewes. Research in Veterinary Science 11, 540547.CrossRefGoogle ScholarPubMed
Carr, S. B. & Jacobson, D. R. (1968). Method for measurement of gastrointestinal absorption in normal animals, combining portal-carotid differences and telemetered portal flow by Doppler shift. Journal of Dairy Science 51, 721729.CrossRefGoogle ScholarPubMed
Chalmers, M. I., Jaffray, A. E. & White, F. (1971). Movements of ammonia following intraruminal administration of urea or casein. Proceedings of the Nutrition Society 30, 717.CrossRefGoogle ScholarPubMed
Christensen, H. N. (1990). Role of amino acid transport and countertransport in nutrition and metabolism. Physiological Reviews 70, 4377.CrossRefGoogle ScholarPubMed
Christopherson, R. J. & Brockman, R. P. (1989). Effect of feeding and a β-adrenergic blocking agent on oxygen consumption by the portal drained viscera, liver and hind quarters of the sheep. In Energy Metabolism of Farm Animals (EAAP Publication No. 43), pp. 147150 [Van der Honing, Y. & Close, W. H., editors]. Wageningen, Netherlands: Centre for Agricultural Publishing and Documentation (Pudoc).Google Scholar
Clark, J. H., Klusmeyer, T. H. & Cameron, M. R. (1992). Microbial protein synthesis and flows of nitrogen fractions to the duodenum of dairy cows. Journal of Dairy Science 75, 23042323.CrossRefGoogle Scholar
Conrad, H. R., Smith, H. R., Vandersall, J. H., Pounden, W. D. & Hibbs, J. W. (1958). Estimating gastrosplenic blood flow and volatile fatty acid absorption from the forestomachs of calves. Journal of Dairy Science 41, 10941099.CrossRefGoogle Scholar
Crane, R. K. & Wilson, T. H. (1958). In vitro method for the study of the rate of intestinal absorption of sugars. Journal of Applied Physiology 12, 145146.CrossRefGoogle Scholar
Danilson, D. A., Webb, K. E. & Herbein, J. H. (1987). Transport and hindlimb exchange of peptide and serum protein amino acids in calves fed soy- or urea-based purified diets. Journal of Animal Science 64, 18521857.CrossRefGoogle ScholarPubMed
DeGregorio, R. M., Tucker, R. E., Mitchell, G. E. & Gill, W. W. (1984). Acetate and propionate production in the cecum and proximal colon of lambs. Journal of Animal Science 58, 203207.CrossRefGoogle ScholarPubMed
Durand, D., Bauchart, D., LeFaivre, J. & Donnat, J. P. (1988). Method for continuous measurement of blood metabolite hepatic balance in conscious preruminant calves. Journal of Dairy Science 71, 16321637.CrossRefGoogle ScholarPubMed
Eisemann, J. H. & Nienaber, J. A. (1990). Tissue and whole-body oxygen uptake in fed and fasted steers. British Journal of Nutrition 64, 399411.CrossRefGoogle ScholarPubMed
Elwyn, D. H. (1970). The role of the liver in regulation of amino acid and protein metabolism. In Mammalian Protein Metabolism, Vol. 4. pp. 523557 [Munro, H. N., editor]. New York: Academic Press.CrossRefGoogle Scholar
Faichney, G. J. (1969). Production of volatile fatty acids in the sheep caecum. Australian Journal of Agricultural Research 20, 491498.CrossRefGoogle Scholar
Faulkner, A. & Pollock, H. T. (1990). Effects of glucagon and α- and β-agonists on glycogenolysis and gluconeogenesis in isolated ovine hepatocytes. Biochimica et Biophysica Acta 1052, 229234.CrossRefGoogle ScholarPubMed
Fell, B. F., Campbell, R. M., Mackie, W. S. & Weekes, T. E. C. (1972). Changes associated with pregnancy and lactation in some extra-reproductive organs of the ewe. Journal of Agricultural Science 79, 397407.CrossRefGoogle Scholar
Fell, B. F. & Weekes, T. E. C. (1975). Food intake as a mediator of adaptation in the ruminal epithelium. In Digestion and Metabolism in the Ruminant, pp. 101118 [McDonald, I. W. & Warner, A. C. I., editors]. Armidale, NSW, Australia: University of New England Publishing Unit.Google Scholar
Gross, K. L., Harmon, D. L. & Avery, T. B. (1990 a). Portal-drained visceral flux of nutrients in lambs fed alfalfa or maintained by total intragastric infusion. Journal of Animal Science 68, 214221.CrossRefGoogle ScholarPubMed
Gross, K. L., Harmon, D. L., Minton, J. E. & Avery, T. B. (1990 b). Effects of isoenergetic infusions of propionate and glucose on portal-drained visceral nutrient flux and concentrations of hormones in lambs maintained by total intragastric infusion. Journal of Animal Science 68, 25662574.CrossRefGoogle ScholarPubMed
Guerino, F., Huntington, G. B. & Erdman, R. A. (1991). The net portal and hepatic flux of metabolites and oxygen consumption in growing beef steers given postruminal casein. Journal of Animal Science 69, 387395.CrossRefGoogle ScholarPubMed
Hancock, M. J. & Milligan, L. P. (1985). Distribution of portal blood to the liver of sheep. Journal of Animal Science 61 (Suppl. 1), 454455.Google Scholar
Harmon, D. L. (1991). Volatile fatty acid and glucose utilisation by the portal-drained viscera in ruminants. In Proceedings of the 12th EAAP Symposium on Energy Metabolism in Farm Animals (EAAP Publication No. 58) [Wenk, C. & Boessinger, M., editors]. Zürich, Switzerland: ETH-Zentrum.Google Scholar
Harmon, D. L. (1992). Dietary influences on carbohydrases and small intestinal starch hydrolysis capacity in ruminants. Journal of Nutrition 122, 203210.CrossRefGoogle ScholarPubMed
Harmon, D. L., Avery, T. B., Huntington, G. B. & Reynolds, P. J. (1988). Influence of ionophore addition to roughage and high-concentrate diets on portal blood flow and net nutrient flux in cattle. Canadian Journal of Animal Science 68, 419429.CrossRefGoogle Scholar
Harmon, D. L., Gross, K. L., Krehbiel, C. R., Kreikemeier, K. K., Bauer, M. L. & Britton, R. A. (1991 a). Influence of dietary forage and energy intake on metabolism and acyl-CoA synthetase activity in bovine ruminal epithelial tissue. Journal of Animal Science 69, 41174127.CrossRefGoogle ScholarPubMed
Harmon, D. L., Gross, K. L., Krehbiel, C. R., Kreikemeier, K. K., Coffey, K. P., Avery, T. B. & Klindt, J. (1991 b). Effects of feeding endophyte-infected fescue hay on portal and hepatic nutrient flux in steers. Journal of Animal Science 69, 12231231.CrossRefGoogle ScholarPubMed
Harmon, D. L., Kreikemeier, K. K. & Gross, K. L. (1993). Influence of addition of monensin to an alfalfa hay diet on net portal and hepatic nutrient flux in steers. Journal of Animal Science 71, 218225.CrossRefGoogle Scholar
Harris, P. M., Skene, P. A., Buchan, V., Milne, E., Calder, A. G., Anderson, S. E., Connell, A. & Lobley, G. E. (1992). Effect of food intake on hind-limb and whole-body protein metabolism in young growing sheep: chronic studies based on arterio-venous techniques. British Journal of Nutrition 68, 389407.CrossRefGoogle ScholarPubMed
Häussinger, D. (1983). Hepatocyte heterogeneity in glutamine and ammonia metabolism and the role of an intercellular glutamine cycle during ureogenesis in perfused rat liver. European Journal of Biochemistry 133, 269275.CrossRefGoogle ScholarPubMed
Health, T. J. & Perkins, N. R. (1985). Effect of development of the ovine forestomachs on the anatomy of portal vessels and on the intrahepatic distribution of portal blood. Research in Veterinary Science 39, 216221.CrossRefGoogle Scholar
Hediger, M. A., Coady, M. J., Ikeda, T. S. & Wright, E. M. (1987 a). Expression cloning and cDNA sequencing of the Na-/glucose co-transporter. Nature 330, 379381.CrossRefGoogle ScholarPubMed
Hediger, M. A., Ikeda, T., Coady, M., Gundersen, C. B. & Wright, E. M. (1987 b). Expression of size-selected mRNA encoding the intestinal Na/glucose cotransporter in Xenopus laevis oocytes. Proceedings of the National Academy of Sciences, USA 84, 26342637.CrossRefGoogle ScholarPubMed
Heitmann, R. N. & Bergman, E. N. (1981). Glutamate interconversions and glucogenicity in the sheep. American Journal of Physiology 241, E465E472.Google ScholarPubMed
Heitmann, R. N., Sensenig, S. C., Reynolds, C. K., Fernandez, J. M. & Dawes, D. J. (1986). Changes in energy metabolite and regulatory hormone concentrations and net fluxes across splanchnic and peripheral tissues in fed and progressively fasted ewes. Journal of Nutrition 116, 25162524.CrossRefGoogle ScholarPubMed
Hidalgo, I. J., Raub, T. J. & Borchardt, R. T. (1989). Characterization of the human colon carcinoma cell line Caco-2 as a model system for intestinal epithelial permeability. Gastroenterology 96, 736749.CrossRefGoogle Scholar
Huntington, G. B. (1982). Portal blood flow and net absorption of ammonia-nitrogen, urea-nitrogen and glucose in nonlactating Holstein cows. Journal of Dairy Science 65, 11551162.CrossRefGoogle ScholarPubMed
Huntington, G. B. (1983). Net nutrient absorption in beef steers fed silage or high concentrate diets containing four levels of limestone. Journal of Nutrition 113, 11571164.CrossRefGoogle ScholarPubMed
Huntington, G. B. (1986). Uptake and transport of nonprotein nitrogen by the ruminant gut. Federation Proceedings 45, 22722276.Google ScholarPubMed
Huntington, G. B. (1989). Hepatic urea synthesis and site and rate of urea removal from blood of beef steers fed alfalfa hay or a high concentrate diet. Canadian Journal of Animal Science 69, 215223.CrossRefGoogle Scholar
Huntington, G. B. & Eisemann, J. H. (1988). Regulation of nutrient supply by gut and liver tissues. Journal of Animal Science 66 (Suppl. 3), 3548.Google Scholar
Huntington, G. B., Eisemann, J. H. & Whitt, J. M. (1990). Portal blood flow in beef steers: comparison of techniques and relation to hepatic blood flow, cardiac output and oxygen uptake. Journal of Animal Science 68, 16661673.CrossRefGoogle ScholarPubMed
Huntington, G. B. & Prior, R. L. (1983). Digestion and absorption of nutrients by beef heifers fed a high concentrate diet. Journal of Nutrition 113, 22802288.CrossRefGoogle ScholarPubMed
Huntington, G. B., Prior, R. L. & Britton, R. A. (1980). Glucose and lactate absorption and metabolic interrelationships in lambs switched from low to high concentrate diets. Journal of Nutrition 110, 19041913.CrossRefGoogle ScholarPubMed
Huntington, G. B. & Reynolds, P. J. (1983). Net volatile fatty acid absorption in nonlactating Holstein cows. Journal of Dairy Science 66, 8692.CrossRefGoogle ScholarPubMed
Huntington, G. B. & Reynolds, P. J. (1986). Net absorption of glucose, l-lactate, volatile fatty acids, and nitrogenous compounds by bovine given abomasal infusions of starch or glucose. Journal of Dairy Science 69, 24282436.CrossRefGoogle ScholarPubMed
Huntington, G. B., Reynolds, C. K. & Stroud, B. H. (1989). Techniques for measuring blood flow in the splanchnic tissues of cattle. Journal of Dairy Science 72, 15831595.CrossRefGoogle ScholarPubMed
Huntington, G. B., Reynolds, P. J. & Tyrrell, H. F. (1983). Net absorption and ruminal concentrations of metabolites in nonpregnant dry Holstein cows before and after intraruminal acetic acid infusion. Journal of Dairy Science 66, 19011908.CrossRefGoogle ScholarPubMed
Huntington, G. B. & Tyrrell, H. F. (1985). Oxygen consumption by portal-drained viscera of cattle: comparison of analytical methods and relationship to whole-body oxygen consumption. Journal of Dairy Science 68, 27272731.CrossRefGoogle ScholarPubMed
Huntington, G. B., Varga, G. A., Glenn, B. P. & Waldo, D. R. (1988). Net absorption and oxygen consumption by Holstein steers fed alfalfa or orchardgrass silage at two equalized intakes. Journal of Animal Science 66, 12921302.CrossRefGoogle ScholarPubMed
Johnson, D. E., Johnson, K. A. & Baldwin, R. L. (1990). Changes in liver and gastrointestinal tract energy demands in response to physiological workload in ruminants. Journal of Nutrition 120, 649655.CrossRefGoogle ScholarPubMed
Kaback, H. R. (1960). Uptake of amino acids by 'ghosts' of mutant strains of E coli. Federation Proceedings 19, 130.Google Scholar
Katz, M. L. & Bergman, E. N. (1969 a). A method for simultaneous cannulation of the major splanchnic blood vessels of the sheep. American Journal of Veterinary Research 30, 655661.Google ScholarPubMed
Katz, M. L. & Bergman, E. N. (1969 b). Simultaneous measurements of hepatic and portal venous blood flow in the sheep and dog. American Journal of Physiology 216, 946952.CrossRefGoogle ScholarPubMed
Katz, N. R. (1992). Metabolic heterogeneity of hepatocytes across the liver acinus. Journal of Nutrition 122, 843849.CrossRefGoogle ScholarPubMed
Kelly, J. M., Vaage, A. S., McBride, B. W. & Milligan, L. P. (1989). Oxygen consumption and the energy costs of Na+, K+-ATPase in rumen epithelial papillae from Hereford steers. Journal of Dairy Science 72 (Suppl. 1), 560.Google Scholar
Koeln, L. L. & Webb, K. E. (1982). Peptide, erythrocyte and plasma amino acid transport across gastrointestinal tract and liver of calves. Federation Proceedings 41, 948.Google Scholar
Krebs, H. A. & Henseleit, K. (1932). [ Formation of urea in the animal body.] Hoppe-Seyler's Zeitschrift für Physiologische Chemie 210, 3366.CrossRefGoogle Scholar
Krehbiel, C. R., Harmon, D. L. & Schneider, J. E. (1992). Effects of increasing ruminal butyrate on portal and hepatic nutrient flux in steers. Journal of Animal Science 70, 904914.CrossRefGoogle ScholarPubMed
Kreikemeier, K. K., Harmon, D. L., Brandt, R. T. J., Avery, T. B. & Johnson, D. E. (1991). Small intestinal starch digestion in steers: effects of various levels of abomasal glucose, corn starch and corn dextrin infusion on small intestinal disappearance and net glucose absorption. Journal of Animal Science 69, 328338.CrossRefGoogle ScholarPubMed
Lobley, G. E., Milne, V., Lovie, J. M., Reeds, P. J. & Pennie, K. (1980). Whole-body and tissue protein synthesis in cattle. British Journal of Nutrition 43, 491502.CrossRefGoogle ScholarPubMed
Lomax, M. A. & Baird, G. D. (1983). Blood flow and nutrient exchange across the liver and gut of the dairy cow. Effects of lactation and fasting. British Journal of Nutrition 49, 481496.CrossRefGoogle ScholarPubMed
MacRae, J. C., Lobley, G. E., Bruce, L. A., Luo, Q., Calder, A. G. & Farningham, D. A. H. (1993). Leucine kinetics across the portal drained viscera of sheep. Journal of Animal Science 71 (Suppl. 1), 279.Google Scholar
Maltby, S. A. (1993). Nutritional Regulation of Splanchnic Nitrogen and Energy Metabolism. PhD Thesis, University of Reading.Google Scholar
Maltby, S. A., Lomax, M. A., Beever, D. E. & Pippard, C. J. (1991). The effect of increased ammonia and amino acid supply on postprandial portal-drained viscera and hepatic metabolism in growing steers fed maize silage. In Proceedings of the 12th Symposium on Energy Metabolism of Farm Animals (EAAP Publication No. 58), pp. 2023 [Wenk, C. & Boessinger, M., editors]. Zürich, Switzerland: ETH-Zentrum.Google Scholar
Mayes, R. W. & Ørskov, E. R. (1974). The utilization of gelled maize starch in the small intestine of sheep. British Journal of Nutrition 32, 143153.CrossRefGoogle ScholarPubMed
McBride, B. W., Early, R. J. & Ball, R. O. (1989). Protein synthesis and energy costs of Na+, K+-transport in tissues of somatotropin treated steers. In Energy Metabolism of Farm Animals (EAAP Publication No. 43), pp. 107111 [Van der Honing, Y. & Close, W. H., editors]. Wageningen, Netherlands: Centre for Agricultural Publishing and Documentation (Pudoc).Google Scholar
McBride, B. W. & Kelly, J. M. (1990). Energy cost of absorption and metabolism in the ruminant gastrointestinal tract and liver: a review. Journal of Animal Science 68, 29973010.CrossRefGoogle ScholarPubMed
McBride, B. W. & Milligan, L. P. (1984). The effect of lactation on ouabain-sensitive respiration of the duodenal mucosa of cows. Canadian Journal of Animal Science 64, 817824.CrossRefGoogle Scholar
McBride, B. W. & Milligan, L. P. (1985). Influence of feed intake and starvation on the magnitude of Na+, K+-ATPase-dependent respiration in duodenal mucosa of sheep. British Journal of Nutrition 53, 605614.CrossRefGoogle ScholarPubMed
McCormick, M. E. & Webb, K. E. (1982). Plasma free, erythrocyte free, and plasma peptide amino acid exchange of calves in steady state and fasting metabolism. Journal of Nutrition 112, 276282.CrossRefGoogle ScholarPubMed
McGuire, M. A., Beede, D. K., DeLorenzo, M. A., Wilcox, C. J., Huntington, G. B., Reynolds, C. K. & Collier, R. J. (1989). Effects of thermal stress and level of feed intake on portal plasma flow and net fluxes of metabolites in lactating Holstein cows. Journal of Animal Science 67, 10501060.CrossRefGoogle ScholarPubMed
McLean, J. A. (1972). On the calculation of heat production from open-circuit calorimetric measurements. British Journal of Nutrition 27, 597600.CrossRefGoogle ScholarPubMed
Munck, B. G. (1972). Methodological problems in the study of amino acid transport by the small intestine. In Transport Across the Intestine, pp. 169194 [Burland, W. L. & Samuel, P. D., editors]. London, England: Churchill Livingstone.Google Scholar
Newsholme, E. A. & Leach, A. R. (1983). Amino acid metabolism. In Biochemistry for Medical Sciences, pp. 382440 [Newsholme, E. A. & Leach, A. R., editors]. New York: John Wiley & Son.Google Scholar
Nocek, J. E. & Tamminga, S. (1991). Site of digestion of starch in the gastrointestinal tract of dairy cows and its effect on milk yield and composition. Journal of Dairy Science 74, 35983629.CrossRefGoogle ScholarPubMed
Owens, F. N. & Hanson, C. F. (1992). External and internal markers for appraising site and extent of digestion in ruminants. Journal of Dairy Science 75, 26052617.CrossRefGoogle ScholarPubMed
Owens, F. N., Zinn, R. A. & Kim, Y. K. (1986). Limits to starch digestion in the ruminant small intestine. Journal of Animal Science 63, 16341648.CrossRefGoogle ScholarPubMed
Parker, D. S. (1990). Manipulation of the functional activity of the gut by dietary and other means (antibiotics/probiotics) in ruminants. Journal of Nutrition 120, 639648.CrossRefGoogle ScholarPubMed
Pearson, W. N., Schwink, T. & Reich, M. (1966). In vitro studies of zinc absorption in the rat. In Zinc Metabolism, pp. 239249 [Prasad, A. S., editor]. Springfield, IL: C. C. Thomas.Google Scholar
Pennington, R. J. (1952). The metabolism of short-chain fatty acids in the sheep. 1. Fatty acid utilization and ketone body production by the rumen epithelium and other tissues. Biochemical Journal 51, 251258.CrossRefGoogle Scholar
Peters, J. P., Shen, R. Y. W., Robinson, J. A. & Chester, S. T. (1990). Disappearance and passage of propionic acid from the rumen of the beef steer. Journal of Animal Science 68, 33373349.CrossRefGoogle ScholarPubMed
Phillips, W. A., Webb, K. E. & Fontenot, J. P. (1976). In vitro absorption of amino acids by the small intestine of sheep. Journal of Animal Science 42, 201207.CrossRefGoogle Scholar
Piccioli Cappelli, F., Seal, C. J. & Parker, D. S. (1993 a). Portal glucose absorption and utilization in sheep receiving exogenous glucose intravascularly or intraduodenally. Journal of Animal Science 71 (Suppl. 1), 279.Google Scholar
Piccioli Cappelli, F., Seal, C. J. & Parker, D. S. (1993 b). [1-13C]Leucine uptake into the portal vein of sheep receiving exogenous glucose intravascularly or intraduodenally. Proceedings of the Nutrition Society 52, 192A.Google Scholar
Pogson, C. I., Carpenter, W. R., Cook, J. S., Fisher, M. J., Lomax, M. A., Salter, M. & Stanley, J. C. (1984). A critical approach to the use of isolated liver cells for the study of metabolic events. Proceedings of the Nutrition Society 43, 119132.CrossRefGoogle Scholar
Prewitt, L. R., Jacobson, D. R., Hemken, R. W. & Hatton, R. H. (1975). Portal blood flow as measured by the Doppler shift technique in sheep fed chopped forages. Journal of Animal Science 41, 596600.CrossRefGoogle ScholarPubMed
Ratner, S. (1947). The enzymatic mechanism of arginine formation from citrulline. Journal of Biological Chemistry 170, 761762.CrossRefGoogle Scholar
Read, M. V. P. (1988). Amino Acid and Metabolite Responses in Portal and Peripheral Blood of Silage-fed Sheep. PhD Thesis, Newcastle upon Tyne.Google Scholar
Reeds, P. J., Burrin, D. G., Davis, T. A. & Fiorotto, M. L. (1993). Postnatal growth of gut and muscle: competitors or collaborators? Proceedings of the Nutrition Society 52, 5767.CrossRefGoogle ScholarPubMed
Reynolds, C. K. (1992). Metabolism of nitrogenous compounds by ruminant liver. Journal of Nutrition 122, 850854.CrossRefGoogle ScholarPubMed
Reynolds, C. K., Casper, D. P., Harmon, D. L. & Milton, C. T. (1992 a). Effect of CP and ME intake on visceral nutrient metabolism in beef steers. Journal of Animal Science 70 (Suppl. 1), 315.Google Scholar
Reynolds, C. K. & Huntington, G. B. (1988 a). Partition of portal-drained visceral net flux in beef steers, 1. Blood flow and net flux of oxygen, glucose and nitrogenous compounds across stomach and post-stomach tissues. British Journal of Nutrition 60, 539551.CrossRefGoogle ScholarPubMed
Reynolds, C. K. & Huntington, G. B. (1989 b). Partition of portal-drained visceral net flux in beef steers. 2. Net flux of volatile fatty acids, d-β-hydroxybutyrate and l-lactate across stomach and post-stomach tissues. British Journal of Nutrition 60, 553562.CrossRefGoogle Scholar
Reynolds, C. K., Huntington, G. B., Elsasser, T. H., Tyrrell, H. F. & Reynolds, P. J. (1989). Net metabolism of hormones by portal-drained viscera and liver of lactating Holstein cows. Journal of Dairy Science 72, 14591468.CrossRefGoogle ScholarPubMed
Reynolds, C. K., Huntington, G. B., Tyrrell, H. F. & Reynolds, P. J. (1986). Splanchnic tissue and whole animal oxygen consumption by lactating Holstein cows. Journal of Dairy Science 69 (Suppl. 1), 193.Google Scholar
Reynolds, C. K., Huntington, G. B., Tyrrell, H. F. & Reynolds, P. J. (1988 a). Net portal-drained visceral and hepatic metabolism of glucose, L-lactate, and nitrogenous compounds in lactating Holstein cows. Journal of Dairy Science 71, 18031812.CrossRefGoogle ScholarPubMed
Reynolds, C. K., Huntington, G. B., Tyrrell, H. F. & Reynolds, P. J. (1988 b). Net metabolism of volatile fatty acids, d-β-hydroxybutyrate, nonesterified fatty acids, and blood gases by portal-drained viscera and liver of lactating Holstein cows. Journal of Dairy Science 71, 23952405.CrossRefGoogle Scholar
Reynolds, C. K., Lapierre, H., Tyrrell, H. F., Elsasser, T. H., Casper, D., Gaudreau, P. & Brazeau, P. (1993 a). Intake and growth hormone-releasing factor (GRF) affect visceral metabolism of VFA in growing beef steers. Journal of Animal Science 71 (Suppl.1), 270.Google Scholar
Reynolds, C. K., Lapierre, H., Tyrrell, H. F., Elsasser, T. H., Staples, R. C., Gaudreau, P. & Brazeau, P. (1992 b). Effects of growth-hormone releasing factor and feed intake on energy metabolism in growing beef steers: net nutrient metabolism by the portal-drained viscera and liver. Journal of Animal Science 70, 752763.CrossRefGoogle ScholarPubMed
Reynolds, C. K. & Tyrrell, H. F. (1991). Effects of mesenteric vein l-alanine infusion on liver metabolism in beef heifers fed on diets differing in forage: concentrate ratio. British Journal of Nutrition 66, 437450.CrossRefGoogle ScholarPubMed
Reynolds, C. K., Tyrrell, H. F. & Armentano, L. E. (1992 c). Effects of mesenteric vein n-butyrate infusion on liver metabolism by beef steers. Journal of Animal Science 70, 22502261.CrossRefGoogle ScholarPubMed
Reynolds, C. K., Tyrrell, H. F. & Harmon, D. L. (1991 a). Effects of diet forage-to-concentrate ratio and mesenteric vein l-alanine infusion on visceral metabolism of volatile fatty acids in beef heifers. Journal of Dairy Science 74 (Suppl. 1), 257.Google Scholar
Reynolds, C. K., Tyrrell, H. F. & Reynolds, P. J. (1991 b). Effects of diet forage-to-concentrate ratio and intake on energy metabolism in growing beef heifers: whole body energy and nitrogen balance and visceral heat production. Journal of Nutrition 121, 9941003.CrossRefGoogle ScholarPubMed
Reynolds, C. K., Tyrrell, H. F. & Reynolds, P. J. (1991 c). Effects of diet forage-to-concentrate ratio and intake on energy metabolism in growing beef heifers: net nutrient metabolism by visceral tissues. Journal of Nutrition 121, 10041015.CrossRefGoogle ScholarPubMed
Reynolds, C. K., Tyrrell, H. F. & Reynolds, P. J. (1993 b). Effects of diet forage-to-concentrate ratio and intake on net visceral metabolism of VFA in growing beef heifers. Journal of Dairy Science 76 (Suppl. 1), 283.Google Scholar
Roe, W. E., Bergman, E. N. & Kon, K. (1966). Absorption of ketone bodies and other metabolites via the portal blood of sheep. American Journal of Veterinary Research 27, 729736.Google ScholarPubMed
Rooney, L. W. & Pfugfclder, R. L. (1986). Factors affecting starch digestibility with special emphasis on sorghum and corn. Journal of Animal Science 63, 16071623.CrossRefGoogle ScholarPubMed
Sakata, T. & Tamate, H. (1978). Rumen epithelial cell proliferation accelerated by rapid increase in intraruminal butyrate. Journal of Dairy Science 61, 11091113.CrossRefGoogle ScholarPubMed
Schambye, P. (1955). Experimental estimation of the portal vein blood flow in sheep. I. Examination of an infusion method and results from acute experiments. Nordisk Veterinaer Medicin 7, 961975.Google Scholar
Seal, C. J. & Heaton, F. W. (1983). Chemical factors affecting the intestinal absorption of zinc in vitro and in vivo. British Journal of Nutrition 50, 317324.CrossRefGoogle ScholarPubMed
Seal, C. J. & Mathers, J. C. (1989). Intestinal zinc transfer by everted gut sacs from rats given diets containing different amounts and types of dietary fibre. British Journal of Nutrition 62, 151163.CrossRefGoogle ScholarPubMed
Seal, C. J. & Parker, D. S. (1991 a). Increased plasma free amino acid concentrations and net absorption of amino acids into portal and mesenteric veins with intra-ruminal propionate infusion into forage-fed steers. In Proceedings of the EAAP 6th International Symposium on Protein Metabolism and Nutrition, Herning, Denmark, pp. 184186 [Eggum, B. O., Boisen, S., Borsting, C., D. A. & Hvelplund, T., editors]. Foulum: National Institute of Animal Science.Google Scholar
Seal, C. J. & Parker, D. S. (1991 b). Isolation and characterization of circulating low molecular weight peptides in steer, sheep and rat portal and peripheral blood. Comparative Biochemistry and Physiology 99B, 679685.Google Scholar
Seal, C. J. & Parker, D. S. (1992). Glucose utilization by portal drained viscera of steers receiving intraruminal propionate infusion. Journal of Animal Science 70 (Suppl. 1), 294.Google Scholar
Seal, C. J. & Parker, D. S. (1993 a). Net mesenteric and portal absorption and rumen metabolism of volatile fatty acids in forage-fed steers receiving intraruminal propionic acid. Animal Production 56, 431A.Google Scholar
Seal, C. J. & Parker, D. S. (1993 b). Net absorption of low molecular weight peptides by the mesenteric and portal drained viscera of steers. Proceedings of the Nutrition Society 52, 190A.Google Scholar
Seal, C. J., Parker, D. S. & Avery, P. J. (1992). The effect of forage and forage-concentrate diets on rumen fermentation and metabolism of nutrients by the mesenteric- and portal-drained viscera in growing steers. British Journal of Nutrition 67, 335370.CrossRefGoogle ScholarPubMed
Seal, C. J., Parker, D. S., Balcells, J. & Mole, J. L. (1993 a). Nitrogen digestion in forage-fed sheep with and without intraruminal propionate infusion. Journal of Agricultural Science 120, 107114.CrossRefGoogle Scholar
Seal, C. J., Parker, D. S. & Lobley, G. E. (1993 b). Effect of intraduodenal starch infusion on glucose metabolism of growing steers fed alfalfa. Journal of Animal Science 71 (Suppl. 1), 279.Google Scholar
Sharp, W. M., Johnson, R. R. & Owens, F. N. (1982). Ruminal VFA production with steers fed whole or ground corn grain. Journal of Animal Science 55, 15051514.CrossRefGoogle ScholarPubMed
Shirazi-Beechey, S. P., Hirayama, B. A., Wang, Y., Scott, D., Smith, M. W. & Wright, E. M. (1991 a). Ontogenic development of lamb intestinal sodium glucose co-transporter is regulated by diet. Journal of Physiology 437, 699708.CrossRefGoogle ScholarPubMed
Shirazi-Beechey, S. P., Smith, M. W., Wang, Y. & James, P. S. (1991 b). Postnatal development of lamb intestinal digestive enzymes is not regulated by diet. Journal of Physiology 437, 691698.CrossRefGoogle Scholar
Shoemaker, W. C. (1964). Methods and techniques for measurement of hepatic physiology and metabolism. In The Liver: Morphology, Biochemistry, Physiology, Volume 2, pp. 243266 [Rouiller, C., editor]. New York: Academic Press.CrossRefGoogle Scholar
Shoemaker, W. C., Walker, T. B., Van Itallie, T. B. & Moore, F. D. (1959). A method for simultaneous catheterization of major hepatic vessels in a chronic canine preparation. American Journal of Physiology 196, 311314.CrossRefGoogle Scholar
Sniffen, C. J. & Jacobson, D. R. (1975). Net amino acid absorption in steers fed alfalfa hay cut at two stages of maturity. Journal of Dairy Science 58, 371385.CrossRefGoogle Scholar
Stangassinger, M. & Giesecke, D. (1986). Splanchnic metabolism of glucose and related energy substrates. In Proceedings of the 6th International Symposium on Ruminant Physiology, pp. 347366 [Milligan, L. P., Grovum, W. L. & Dobson, A., editors]. Englewood Cliffs, NJ: Prentice Hall.Google Scholar
Stevens, C. E. & Stettler, B. K. (1966). Factors affecting the transport of volatile fatty acids across rumen epithelium. American Journal of Physiology 210, 365372.CrossRefGoogle ScholarPubMed
Symonds, H. W. & Baird, G. D. (1973). Cannulation of a hepatic vein, the portal vein and a mesenteric vein in the cow and its use in the measurement of blood flow rates. Research in Veterinary Sciences 14, 267269.CrossRefGoogle Scholar
Tagari, H. & Bergman, E. N. (1978). Intestinal disappearance and portal blood appearance of amino acids in sheep. Journal of Nutrition 108, 790803.CrossRefGoogle ScholarPubMed
Tyrrell, H. F., Moe, P. W. & Flatt, W. P. (1970). Influence of excess protein intake on energy metabolism of the dairy cow. In Proceedings of the 5th Symposium on Energy Metabolism of Farm Animals (EAAP Publication No. 13), pp. 6972 [editors]. Zürich, Switzerland: Juris Druck-Verlag.Google Scholar
Van der Walt, J. G., Baird, G. D. & Bergman, E. N. (1983). Tissue glucose and lactate metabolism and interconversions in pregnant and lactating sheep. British Journal of Nutrition 50, 267280.CrossRefGoogle ScholarPubMed
Vernay, M. (1989). Incidence of the circadian rhythm of the excretion pattern on acetate absorption and metabolism in the rabbit hind-gut. Reproduction, Nutrition, Développment 29, 185196.CrossRefGoogle ScholarPubMed
Waldo, D. R. (1973). Extent and partition of cereal grain starch digestion in ruminants. Journal of Animal Science 37, 10621074.CrossRefGoogle Scholar
Wangsness, P. J. & McGilliard, A. D. (1972). Measurement of portal blood flow in calves by dye dilution. Journal of Dairy Science 55, 14391446.CrossRefGoogle ScholarPubMed
Webb, K. E. & Bergman, E. N. (1991). Amino acid and peptide absorption and transport across the intestine. In Proceedings of the 7th International Symposium on Ruminant Physiology, Sendai, Japan, pp. 111128 [Tsuda, T., Sasaki, Y. & Kawashima, R., editors]. London, UK: Academic Press.Google Scholar
Webb, K. E., Dirienzo, D. B. & Matthews, J. C. (1993). Recent developments in gastrointestinal absorption and tissue utilization of peptides: a review. Journal of Dairy Science 76, 351361.CrossRefGoogle ScholarPubMed
Webb, K. E., Matthews, J. C. & Dirienzo, D. B. (1992). Peptide absorption: a review of current concepts and future perspectives. Journal of Animal Science 70, 32483257.CrossRefGoogle ScholarPubMed
Webster, A. J. F. (1980). Energy costs of digestion and metabolism in the gut. In Digestive Physiology and Metabolism in Ruminants, pp. 469484 [Ruckebusch, Y. & Thivend, P., editors]. Lancaster, UK: MTP Press.CrossRefGoogle Scholar
Webster, A. J. F., Osuji, P. O., White, F. & Ingram, J. F. (1975). The influence of food intake on portal blood flow and heat production in the digestive tract of sheep. British Journal of Nutrition 34, 125139.CrossRefGoogle ScholarPubMed
Weekes, T. E. C. & Webster, A. J. F. (1975). Metabolism of propionate in the tissues of the sheep gut. British Journal of Nutrition 33, 425438.CrossRefGoogle Scholar
White, S. W., Chalmers, J. P., Hilder, R. & Korner, P. I. (1967). Local thermodilution method for measuring blood flow in the portal and renal veins of the unanaesthetized rabbit. Australian Journal of Experimental Biology and Medical Science 45, 453468.CrossRefGoogle ScholarPubMed
Wilson, T. H. & Wiseman, G. (1954). The use of sacs of everted small intestine for the study of the transference of substances from the mucosal to the serosal surface. Journal of Physiology 123, 116125.CrossRefGoogle Scholar
Wilton, J. C. (1989). The Effects of Ammonia upon the Metabolism of Carbohydrates and Amino Acids in the Liver of Growing Steers Offered Silage. PhD Thesis, University of Reading.Google Scholar
Windmueller, H. G. & Spaeth, A. E. (1978). Identification of ketone bodies and glutamine as the major respiratory fuels in vivo for postabsorptive rat small intestine. Journal of Biological Chemistry 253, 6976.CrossRefGoogle ScholarPubMed
Windmueller, H. G. & Spaeth, A. E. (1980). Respiratory fuels and nitrogen metabolism in vivo in small intestine of fed rats. Quantitative importance of glutamine, glutamate and aspartate. Journal of Biological Chemistry 255, 107112.CrossRefGoogle ScholarPubMed
Wolff, J. E., & Bergman, E. N. (1972). Gluconeogenesis from plasma amino acids in fed sheep. American Journal of Physiology 223, 455460.CrossRefGoogle ScholarPubMed
Wolff, J. E., Bergman, E. N. & Williams, H. H. (1972). Net metabolism of plasma amino acids by liver and portaldrained viscera of fed sheep. American Journal of Physiology 223, 438446.CrossRefGoogle ScholarPubMed
Zierler, K. L. (1961). Theory and use of arteriovenous concentration differences for measuring metabolism in steady and non-steady states. Journal of Clinical Investigation 40, 21112125.CrossRefGoogle ScholarPubMed