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Mechanisms involved in the nutritional regulation of mRNA translation: features of the avian model

Published online by Cambridge University Press:  14 December 2007

Sophie Tesseraud*
Affiliation:
Institut National de la Recherche Agronomique, Tours, 37 380 Nouzilly, France
Mourad Abbas
Affiliation:
Institut National de la Recherche Agronomique, Tours, 37 380 Nouzilly, France
Sophie Duchene
Affiliation:
Institut National de la Recherche Agronomique, Tours, 37 380 Nouzilly, France
Karine Bigot
Affiliation:
Institut National de la Recherche Agronomique, Tours, 37 380 Nouzilly, France
Pascal Vaudin
Affiliation:
Institut National de la Recherche Agronomique, Tours, 37 380 Nouzilly, France
Joëlle Dupont
Affiliation:
Institut National de la Recherche Agronomique, Tours, 37 380 Nouzilly, France
*
*Corresponding author: Dr Sophie Tesseraud, fax +33 2 47 42 77 78, email [email protected]
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Abstract

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Abstract:Insulin and amino acids are key factors in regulating protein synthesis. The mechanisms of their action have been widely studied for several years. The insulin signal is mediated by the activation of intracellular kinases such as phosphatidylinositol–3'kinase and the mammalian target of rapamycin (mTOR), affecting the phosphorylation of some major effectors involved in the regulation of translation initiation, i.e. p70 S6 kinase (p70S6K) and the translational repressor eukaryotic initiation factor 4E binding protein (4E-BP1). The amino acid–induced signalling cascade also originates from mTOR and promotes p70S6K and 4E–BP1 activation. However, the mechanisms of regulation are complex and little understood, especially in vivo. Elucidating these mechanisms is important for both fundamental physiology and nutritional applications, i.e. better control of the use of nutrients and optimisation of dietary amino acid supplies in various physiological and physiopathological situations. In comparative physiology, the chicken is an interesting model to gain better understanding of the nutritional regulation of mRNA translation because of the very high rates of muscle growth and protein synthesis, and the unusual features compared with mammals. In the present review we provide an overview of the roles of insulin and amino acids as regulators of protein synthesis in both mammals and avian species.

Type
Research Article
Copyright
Copyright © The Authors 2006

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