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The influence of zinc levels on osteoarthritis: A comprehensive review

Published online by Cambridge University Press:  23 September 2024

İbrahim Tekeoğlu ,
Muhammed Zahid Şahin Open the ORCID record for Muhammed Zahid Şahin [Opens in a new window] ,
Ayhan Kamanlı  and
Kemal Nas
İbrahim Tekeoğlu
Affiliation:
Sakarya University Faculty of Medicine, Department of Rheumatology, Sakarya University Training and Research Hospital, Sakarya, Türkiye
Muhammed Zahid Şahin*
Affiliation:
Sakarya University Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Sakarya University Training and Research Hospital, Sakarya, Türkiye
Ayhan Kamanlı
Affiliation:
Sakarya University Faculty of Medicine, Department of Rheumatology, Sakarya University Training and Research Hospital, Sakarya, Türkiye
Kemal Nas
Affiliation:
Sakarya University Faculty of Medicine, Department of Rheumatology, Sakarya University Training and Research Hospital, Sakarya, Türkiye
*
*Corresponding author: Muhammed Zahid Şahin, email: [email protected]
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Abstract

Osteoarthritis (OA), a disease with a multifactorial aetiology and an enigmatic root cause, affects the quality of life of many elderly patients. Even though there are certain medications utilised to reduce the symptomatic effects, a reliable treatment method to reverse the disease is yet to be discovered. Zinc is a cofactor of over 3000 proteins and is the only metal found in all six classes of enzymes. We explored zinc’s effect on the immune system and the bones as OA affects both. We also discussed zinc-dependent enzymes, highlighting their significant role in the disease’s pathogenesis. It is important to note that both excessive and deficient zinc levels can negatively affect bone health and immune function, thereby exacerbating OA. The purpose of this review is to offer a better understanding of zinc’s impact on OA pathogenesis and to provide clarity regarding its beneficial and detrimental outcomes. We searched thoroughly systematic reviews, meta-analysis, review articles, research articles and randomised controlled trials to ensure a comprehensive review. In brief, using zinc supplementation in the treatment of OA may act as a doubled-edged sword, offering potential benefits but also posing risks.

Keywords

boneenzymesimmunityosteoarthritispathophysiologyzinc
Type
Review Article
Information
Nutrition Research Reviews , First View , pp. 1 - 12
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© The Author(s), 2024. Published by Cambridge University Press on behalf of The Nutrition Society

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