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Ferroptosis Regulation by Nutrient Signalling

Published online by Cambridge University Press:  08 July 2021

Yingao Qi ,
Xiaoli Zhang ,
Zhihui Wu ,
Min Tian ,
Fang Chen ,
Wutai Guan  and
Shihai Zhang Open the ORCID record for Shihai Zhang [Opens in a new window]
Yingao Qi
Affiliation:
Guangdong Province Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China
Xiaoli Zhang
Affiliation:
Guangdong Province Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China
Zhihui Wu
Affiliation:
Guangdong Province Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China
Min Tian
Affiliation:
Guangdong Province Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China
Fang Chen
Affiliation:
Guangdong Province Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China College of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou510642, China
Wutai Guan*
Affiliation:
Guangdong Province Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China College of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou510642, China
Shihai Zhang*
Affiliation:
Guangdong Province Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China College of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou510642, China Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, United States
*
*Correspondence: Wutai Guan, email: [email protected]; Shihai Zhang, Email: [email protected]
*Correspondence: Wutai Guan, email: [email protected]; Shihai Zhang, Email: [email protected]
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Abstract

Tremendous progress has been made in the field of ferroptosis since this regulated cell death process was first named in 2012. Ferroptosis is initiated upon redox imbalance and driven by excessive phospholipid peroxidation. Levels of multiple intracellular nutrients (iron, selenium, vitamin E and coenzyme Q10) are intimately related to the cellular antioxidant system and participate in the regulation of ferroptosis. Dietary intake of monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA) regulates ferroptosis by directly modifying the fatty acid composition in cell membranes. In addition, amino acids and glucose (energy stress) manipulate the ferroptosis pathway through the nutrient-sensitive kinases mechanistic target of rapamycin complex 1 (mTORC1) and AMP-activated protein kinase (AMPK). Understanding the molecular interaction between nutrient signals and ferroptosis sensors might help in the identification of the roles of ferroptosis in normal physiology and in the development of novel pharmacological targets for the treatment of ferroptosis-related diseases.

Keywords

Nutrient sensingSeFeAMPKmTORC1Ferroptosis
Type
Review Article
Information
Nutrition Research Reviews , Volume 35 , Issue 2 , December 2022 , pp. 282 - 294
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Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of The Nutrition Society

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