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Effects of betaine on non-alcoholic liver disease

Published online by Cambridge University Press:  05 April 2021

Weiqiang Chen ,
Minjuan Xu ,
Minwen Xu ,
Yucai Wang ,
Qingyan Zou ,
Shuixiang Xie  and
Liefeng Wang
Weiqiang Chen
Affiliation:
Guangzhou Kingmed Diagnostics Group Co., Ltd., Guangzhou, 510320, China Key Laboratory of Prevention and treatment of cardiovascular and cerebrovascular diseases, Ministry of Education, Gannan Medical University, Ganzhou, 341000, China
Minjuan Xu
Affiliation:
Department of Obstetrics and Gynecology, Ganzhou People’s Hospital, Ganzhou, 341000, China
Minwen Xu
Affiliation:
First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, China
Yucai Wang
Affiliation:
First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, China
Qingyan Zou
Affiliation:
First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, China
Shuixiang Xie*
Affiliation:
Key Laboratory of Prevention and treatment of cardiovascular and cerebrovascular diseases, Ministry of Education, Gannan Medical University, Ganzhou, 341000, China
Liefeng Wang*
Affiliation:
Key Laboratory of Prevention and treatment of cardiovascular and cerebrovascular diseases, Ministry of Education, Gannan Medical University, Ganzhou, 341000, China
*
*Correspondence authors: Shuixiang Xie, email [email protected] and Liefeng Wang [email protected]
*Correspondence authors: Shuixiang Xie, email [email protected] and Liefeng Wang [email protected]
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Abstract

The increasing prevalence of non-alcoholic fatty liver disease (NAFLD) poses a growing challenge in terms of its prevention and treatment. The ‘multiple hits’ hypothesis of multiple insults, such as dietary fat intake, de novo lipogenesis, insulin resistance, oxidative stress, mitochondrial dysfunction, gut dysbiosis and hepatic inflammation, can provide a more accurate explanation of the pathogenesis of NAFLD. Betaine plays important roles in regulating the genes associated with NAFLD through anti-inflammatory effects, increased free fatty oxidation, anti-lipogenic effects and improved insulin resistance and mitochondrial function; however, the mechanism of betaine remains elusive.

Keywords

BetaineNAFLDAMPK
Type
Review Article
Information
Nutrition Research Reviews , Volume 35 , Issue 1 , June 2022 , pp. 28 - 38
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Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of The Nutrition Society

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Footnotes

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These authors contributed equally to this work.

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