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Synthesis of Core-Shell Biopolymer Particles Using Coaxial Electrospray

Published online by Cambridge University Press:  10 May 2012

Cho Hui Lim  and
Michael E. Mullins
Cho Hui Lim
Affiliation:
Department of Chemical Engineering, Michigan Technological University, Houghton, MI 49931
Michael E. Mullins
Affiliation:
Department of Chemical Engineering, Michigan Technological University, Houghton, MI 49931
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Abstract

Core-shell PLLA microparticles were successfully fabricated using a novel coaxial nozzle design. These particles were synthesized with different components in the core/shell layers representing three classes of systems of interest for drug delivery applications: PVA/PLLA, PLLA/PEG, and oleic acid/PLLA. The components were characterized for their physical properties and interfacial energies, and optimal conditions for the operation were determined. To facilitate the particle characterization, each phase was doped with a different fluorescent dye to aid in the confirmation of a core/shell structure via fluorescence microscopy.

Keywords

core/shellspray depositionbiomedical
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1418: Symposium LL/MM – Gels and Biomedical Materials , 2012 , mrsf11-1418-mm10-19
Copyright
Copyright © Materials Research Society 2012

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References

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