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Quantification of Protein Adsorption on Polyglycerol-based Polymer Network Films

Published online by Cambridge University Press:  08 August 2013

Duygu Ekinci ,
Adam L. Sisson  and
Andreas Lendlein
Duygu Ekinci
Affiliation:
Institute of Biomaterial Science and Berlin Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Kantstr. 55, 14513 Teltow, Germany.
Adam L. Sisson
Affiliation:
Institute of Biomaterial Science and Berlin Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Kantstr. 55, 14513 Teltow, Germany.
Andreas Lendlein
Affiliation:
Institute of Biomaterial Science and Berlin Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Kantstr. 55, 14513 Teltow, Germany.
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Abstract

Neutral, hydrophilic, polymer-based architectures are widely investigated for a wide range of biomedical applications from drug-conjugates to delivery systems and scaffolds for regenerative therapies. In most cases, it is crucial that biomaterials provide a blank, inert background in order to hinder unspecific cell-material interactions so that protein mediated biological events leading to foreign body reactions are prevented. Hydrophilic polyglycerol-based polymer network films are a recently developed class of amorphous macroscopic materials, which offer great versatility in design and control of resultant properties. In this study, protein adsorption on polyglycerol-based polymer network films is investigated by using Micro BCA protein assay for three types of proteins having critical roles in the human body, and various copolymer networks with differing sidechains and crosslink densities.

Keywords

biomaterialpolymerfilm
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1569: Symposium NN – Advanced Materials for Biological and Biomedical Applications , 2013 , pp. 79 - 84
Copyright
Copyright © Materials Research Society 2013 

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