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Hysteresis modeling of porous SMA for drug delivery system designed and fabricated by the laser-assisted sintering

Published online by Cambridge University Press:  28 June 2013

Igor V. Shishkovsky*
Affiliation:
P.N. Lebedev Physics Institute of Russian Academy of Sciences, Samara branch, Novo-Sadovaja st. 221, Samara 443011, [email protected]
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Abstract

In this report we develop a complete mathematical model for a porous scaffold from nitinol (NiTi – intermetallic phase) with a shape memory effect (SME), fabricated layerwise via the selective laser sintering (SLS) process. The operation of the SME bio-fluidic MEMS involves such physical process as a heat transfer, a phase transformation with a temperature hysteresis, stress-strain and electrical resistance variations accompanied the phase transformation. The simulations were conducted for the electro- and a thermo- mechanical hysteresis phenomenon, during the SME in the porous nitinol structures of the cylinder shape, which allow to formulate a recommendations for SLS. Previously done the temperature evolution of electrical resistivity was compared with our present calculations as a function of the laser-processing parameters for three dimensional nitinol samples. This model can be used for an estimation of a drug delivery system route during a porous phase volume changing.

Type
Articles
Copyright
Copyright © Materials Research Society 2013 

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References

REFERENCES

Hilt, J.Z., Peppas, N.A.. International Journal of Pharmaceutics, 306, 15, (2005).CrossRefGoogle Scholar
Shishkovsky, I.V.. MRS Proceedings, 1415, mrsf11-1415-ii03-10, (2012).Google Scholar
Shishkovsky, I., Sherbakoff, V. et al. . Proc. Instn. Mech. Engrs., Part C, 226 (12), 2882, (2012).Google Scholar
Moore, J.L., McCuiston, A. et al. . Microfluidics and Nanofluidics, 10 (4), 877, (2010).CrossRefGoogle Scholar
Gultepe, E., Nagesha, D., Sridhar, S. et al. . Advanced Drug Delivery Reviews, 62, 305, (2010).CrossRefGoogle Scholar
Cheah, C.M., Leong, K.F., Chua, C.K. et al. . Proc. Instn. Mech. Engrs. Part H, 216, 369, (2002).CrossRefGoogle Scholar
Liew, C.L., Leong, K.F., Chua, C.K., Du, Z.. Int. J. Adv. Manuf. Technol., 18, 717, (2001).CrossRefGoogle Scholar
Arutyunov, Y.I., Zhuravel, L.V. et al. . Physics of metals and metallography, 93(2), 185, (2002).Google Scholar
Dutta, S., Ghorbel, F.. IEEE/ASME Transactions on Mechatronics, 10/2, 1, (2005).CrossRefGoogle Scholar
Ikuta, K., Tsukamoto, M., Hirose, S.. IEEE Micro Electro Mechanical Systems, 103, (1991).Google Scholar
Antonucci, V., Faiella, G., Giordano, M. et al. . Thermochimica Acta, 462, 64, (2007).CrossRefGoogle Scholar
Likhachev, A.. Scripta Metallurgica et Materialia, 32/4, 633, (1995).10.1016/0956-716X(95)90850-JCrossRefGoogle Scholar
Medvedev, A.E.. Mathematical Biology and Bioinformatics, 6 (2),228, (2011).CrossRefGoogle Scholar
Gunter, V.E.. Delay law a new class of materials and implants in medicine. Northampton, MA: STT Publishing, 2000, 432 p.Google Scholar