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Human Mesenchymal Stem Cell Response to 444 Ferritic Stainless Steel Networks

Published online by Cambridge University Press:  25 June 2013

Antonia Symeonidou ,
Rose L Spear ,
Roger A Brooks  and
Athina E Markaki
Antonia Symeonidou
Affiliation:
Department of Engineering, University of Cambridge, Trumpington Street, Cambridge, CB2 1PZ, UK
Rose L Spear
Affiliation:
Department of Engineering, University of Cambridge, Trumpington Street, Cambridge, CB2 1PZ, UK
Roger A Brooks
Affiliation:
Orthopaedic Research Unit, Addenbrooke’s Hospital, Hills Road, Cambridge, CB2 2QQ, UK
Athina E Markaki
Affiliation:
Department of Engineering, University of Cambridge, Trumpington Street, Cambridge, CB2 1PZ, UK
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Abstract

The aim of this work is to improve bone-implant bonding. This can, potentially, be achieved through the use of an implant coating composed of fibre networks. It is hypothesised that such an implant can achieve strong peri-prosthetic bone anchorage, when seeded with human mesenchymal stem cells (hMSCs). The materials employed were 444 and 316L stainless steel fibre networks of the same fibre volume fraction. The present work confirms that hMSCs are able to proliferate and differentiate towards the osteogenic lineage when seeded onto the fibre networks. Cellular viability, proliferation and metabolic activity were assessed and the results suggest higher proliferation rates when hMSC are seeded onto the 444 networks as compared to 316L. Cell distribution was found uniform across the seeded surfaces with 444 showing a somewhat higher infiltration depth.

Keywords

biomaterialbonecellular (material type)
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1569: Symposium NN – Advanced Materials for Biological and Biomedical Applications , 2013 , pp. 73 - 78
Copyright
Copyright © Materials Research Society 2013 

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References

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