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Biodegradable Microfluidic Scaffolds with Tunable Degradation Properties from Amino Alcohol-based Poly(ester amide) Elastomers

Published online by Cambridge University Press:  01 March 2011

Jane Wang ,
Tatiana Kniazeva ,
Carly F. Campbell ,
Robert Langer ,
Jeffrey S. Ustin  and
Jeffrey T. Borenstein
Jane Wang
Affiliation:
Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA, 02139 Biomedical Engineering, Charles Stark Draper Laboratory, Cambridge, MA, USA, 02139 Program of Polymer Science and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA, 02139
Tatiana Kniazeva
Affiliation:
Biomedical Engineering, Charles Stark Draper Laboratory, Cambridge, MA, USA, 02139
Carly F. Campbell
Affiliation:
Biomedical Engineering, Charles Stark Draper Laboratory, Cambridge, MA, USA, 02139
Robert Langer
Affiliation:
Program of Polymer Science and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA, 02139 Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA, 02139
Jeffrey S. Ustin
Affiliation:
Trauma Surgery, Cleveland MetroHealth Hospital, Cleveland, OH, USA, 44106
Jeffrey T. Borenstein
Affiliation:
Biomedical Engineering, Charles Stark Draper Laboratory, Cambridge, MA, USA, 02139
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Abstract

Biodegradable polymers with high mechanical strength, flexibility and optical transparency, optimal degradation properties and biocompatibility are critical to the success of tissue engineered devices and drug delivery systems. In this work, microfluidic devices have been fabricated from elastomeric scaffolds with tunable degradation properties for applications in tissue engineering and regenerative medicine. Most biodegradable polymers suffer from short half life resulting from rapid and poorly controlled degradation upon implantation, exceedingly high stiffness, and limited compatibility with chemical functionalization. Here we report the first microfluidic devices constructed from a recently developed class of biodegradable elastomeric poly(ester amide)s, poly(1,3-diamino-2-hydroxypropane-co-polyol sebacate)s (APS), showing a much longer and highly tunable in vivo degradation half-life comparing to many other commonly used biodegradable polymers. The device is molded in a similar approach to that reported previously for conventional biodegradable polymers, and the bonded microfluidic channels are shown to be capable of supporting physiologic levels of flow and pressure. The device has been tested for degradation rate and gas permeation properties in order to predict performance in the implantation environment. This device is high resolution and fully biodegradable; the fabrication process is fast, inexpensive, reproducible, and scalable, making it the approach ideal for both rapid prototyping and manufacturing of tissue engineering scaffolds and vasculature and tissue and organ replacements.

Keywords

biomaterialmicroelectro-mechanical (MEMS)polymer
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1299: Symposium S – Microelectromechanical Systems—Materials and Devices IV , 2011 , mrsf10-1299-s11-02
Copyright
Copyright © Materials Research Society 2011

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