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Biomimetic Nanohybrids for Combined imaging and Cancer Therapy

Published online by Cambridge University Press:  29 October 2012

A. Topete ,
P. Iglesias ,
M. Alatorre-Meda ,
A. Cambón ,
E. Alvarez ,
J.A. Costoya ,
S. Barbosa ,
P. Taboada  and
V. Mosquera
A. Topete
Affiliation:
Grupo de Física de Coloides y Polímeros
P. Iglesias
Affiliation:
Grupo de Oncología Molecular, Universidad de Santiago de Compostela, 15782, Santiago de Compostela, Spain.
M. Alatorre-Meda
Affiliation:
Grupo de Física de Coloides y Polímeros
A. Cambón
Affiliation:
Grupo de Física de Coloides y Polímeros
E. Alvarez
Affiliation:
Grupo de Física de Coloides y Polímeros
J.A. Costoya
Affiliation:
Grupo de Oncología Molecular, Universidad de Santiago de Compostela, 15782, Santiago de Compostela, Spain.
S. Barbosa
Affiliation:
Grupo de Física de Coloides y Polímeros
P. Taboada
Affiliation:
Grupo de Física de Coloides y Polímeros
V. Mosquera
Affiliation:
Grupo de Física de Coloides y Polímeros
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Abstract

In this work, we have developed a multifunctional theranostic nanoplatform consisting of a poly(lactic-co-glycolic acid) (PLGA) biodegradable matrix covered by a gold shell, which provides the system with NIR absorption ability and subsequent generation of hyperthermia effect. Inside the PLGA nanoparticle, the chemotherapeutic drug doxorubicin (DOXO) and the NIR dye isocyanine green (ICG) were loaded. The characterization of the particles, their in vitro cytotocixity combining NIR light irradiation and chemotherapy and their preliminary in vivo biodistribution is analyzed.

Keywords

absorptioncore/shellbiomedical
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1468: Symposium VV – Nanomedicine for Molecular Imaging and Therapy , 2012 , mrss12-1468-vv06-05
Copyright
Copyright © Materials Research Society 2012

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References

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