Hostname: page-component-586b7cd67f-g8jcs Total loading time: 0 Render date: 2024-11-30T10:55:01.973Z Has data issue: false hasContentIssue false
  • English
  • Français

Synthesis of fluorescent CuInS2/ZnS quantum dots—porphyrin conjugates for photodynamic therapy

Published online by Cambridge University Press:  18 April 2018

Ncediwe Tsolekile ,
Vuyelwa Ncapayi ,
Sundararajan Parani ,
El Hadji Mamour Sakho ,
Mangaka C. Matoetoe ,
Sandile P. Songca  and
Oluwatobi S. Oluwafemi
Ncediwe Tsolekile
Affiliation:
Department of Applied Chemistry, University of Johannesburg, P. O. Box 17011, Doornfontein 2028, Johannesburg, South Africa Centre for Nanomaterials Science Research, University of Johannesburg, Johannesburg, South Africa Department of Chemistry, Cape Peninsula University of Technology, P.O. Box 652, Cape Town 2000, South Africa
Vuyelwa Ncapayi
Affiliation:
Department of Applied Chemistry, University of Johannesburg, P. O. Box 17011, Doornfontein 2028, Johannesburg, South Africa Centre for Nanomaterials Science Research, University of Johannesburg, Johannesburg, South Africa
Sundararajan Parani
Affiliation:
Department of Applied Chemistry, University of Johannesburg, P. O. Box 17011, Doornfontein 2028, Johannesburg, South Africa Centre for Nanomaterials Science Research, University of Johannesburg, Johannesburg, South Africa
El Hadji Mamour Sakho
Affiliation:
Department of Applied Chemistry, University of Johannesburg, P. O. Box 17011, Doornfontein 2028, Johannesburg, South Africa Centre for Nanomaterials Science Research, University of Johannesburg, Johannesburg, South Africa
Mangaka C. Matoetoe
Affiliation:
Department of Chemistry, Cape Peninsula University of Technology, P.O. Box 652, Cape Town 2000, South Africa
Sandile P. Songca
Affiliation:
Department of Chemistry, University of Zululand, PB X1001, Kwadlangezwa 3886, South Africa
Oluwatobi S. Oluwafemi*
Affiliation:
Department of Applied Chemistry, University of Johannesburg, P. O. Box 17011, Doornfontein 2028, Johannesburg, South Africa Centre for Nanomaterials Science Research, University of Johannesburg, Johannesburg, South Africa
*
Address all correspondence to Oluwatobi S. Oluwafemi at [email protected], [email protected]
Get access

Abstract

Porphyrins are photosensitisers used in photodynamic therapy (PDT) due to their tumor localization and in situ singlet oxygen generation. However, their limited absorption, insolubility, and aggregation in an aqueous medium limited their effective application in PDT. To overcome these limitations, we herein, report a large-scale aqueous synthesis of CuInS2/ZnS ternary quantum dots, and its conjugation to 5, 10, 15, 20-meso(4-hydroxyphenyl) porphyrin. The singlet oxygen generation of this highly aqueous soluble novel conjugate shows its potential for PDT applications.

Type
Research Letters
Information
MRS Communications , Volume 8 , Issue 2 , June 2018 , pp. 398 - 403
Check for updates
Copyright
Copyright © Materials Research Society 2018 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Allison, R.R., and Moghissi, K.: Photodynamic therapy (PDT): PDT mechanisms. Clin. Endosc. 46, 24–29 (2013).Google Scholar
2.Subramanian, A.P., Jaganathan, S.K., Manikandan, A., Pandiaraj, K.N., Gomathi, N., and Supriyanto, E.: Recent trends in nano-based drug delivery systems for efficient delivery of phytochemicals in chemotherapy. RSC Adv. 6, 48294–48314 (2016).Google Scholar
3.Debele, T.A., Peng, S., and Tsai, H.C.: Drug carrier for photodynamic cancer therapy. Int. J. Mol. Sci. 16, 22094–22136 (2015).Google Scholar
4.Henderson, B.W., and Dougherty, T.J.: How does photodynamic therapy work? Photochem. Photobiol. 55,145–157 (1992).Google Scholar
5.Malatesti, N., Munitic, I., and Jurak, I.: Porphyrin-based cationic amphiphilic photosensitisers as potential anticancer, antimicrobial and immunosuppressive agents. Biophys. Rev. 9, 149–168 (2017).Google Scholar
6.Huang, H., Song, W., Rieffel, J., and Lovell, J.F.: Emerging applications of porphyrins in photomedicine. Font. Phys. 3, 1–15 (2015).Google Scholar
7.Abrahamse, H., and Hamblin, M.: New photosensitizers for photodynamic therapy. Biochem. J. 473, 347–364 (2016).Google Scholar
8.Debele, T.A., Peng, S., and Tsai, H.C.: Drug carrier for photodynamic cancer therapy. Int. J. Mol. Sci. 16, 22094–22136 (2015).Google Scholar
9.Luksiene, Z.: Photodynamic therapy: mechanism of action and ways to improve the efficiency of treatment. Medicina (B. Aires) 39, 1137–1149 (2003).Google Scholar
10.Viana, O.S., Ribeiro, M.S., Rodas, A.C.D., Rebouças, J.S., Fontes, A., and Santos, B.S.: Comparative study on the efficiency of the photodynamic inactivation of Candida albicans using CdTe quantum dots, Zn(II) porphyrin and their conjugates as photosensitizers. Molecules 20, 8893–8912 (2015).Google Scholar
11.Oluwole, D.O., and Nyokong, T.: Physicochemical behavior of nanohybrids of mono and tetra substituted carboxyphenoxy phthalocyanine covalently linked to GSH-CdTe/CdS/ZnS quantum dots. Polyhedron 87, 8–16 (2015).Google Scholar
12.Frasco, M.F., Vamvakaki, V., and Chaniotakis, N.: Porphyrin decorated CdSe quantum dots for direct fluorescent sensing of metal ions. Nanopart. Res. 12, 1449–1458 (2010).Google Scholar
13.Rotomskis, R. and Streckyte, G.: In Quantum Dots in PDT, Imaging in Photodynamic Therapy, edited by Hamblin, M.R., and Huange, Y. (Taylor and Francis, London, New York, 2017), pp. 183–210.Google Scholar
14.Parani, S., Bupesh, G., Manikandan, E., Pandian, K., and Oluwafemi, O.S.: Facile synthesis of mercaptosuccinic acid-capped CdTe/CdS/ZnS core/double shell quantum dots with improved cell viability on different cancer cells and normal cells. J. Nanopart. Res. 18, 347 (2016).Google Scholar
15.Kang, X., Yang, Y., Huang, L., Tao, Y., Wang, L., and Pan, D.: Large-scale synthesis of water-soluble CuInSe2/ZnS and AgInSe2/ZnS core/shell quantum dots. Green Chem. 17, 4482–4488 (2015).Google Scholar
16.Tsolekile, N., Parani, S., Matoetoe, M.C., Songca, S.P., and Oluwafemi, O.S.: Evolution of ternary I–III–VI QDs: synthesis, characterization and application. Nano-Struct. Nano-Objects 12, 46–56 (2017).Google Scholar
17.Neela Mohan, C., Renuga, V., and Manikandan, A.: Influence of silver precursor concentration on structural, optical and morphological properties of Cu1-xAgxInS2 semiconductor nanocrystals. J. Alloys Compd.729, 407–417 (2017).Google Scholar
18.Chen, Y., Li, S., Huang, L., and Pan, D.: Low-cost and gram-scale synthesis of water soluble Cu–In–S/ZnS core/shell quantum dots in an electric pressure cooker. Nanoscale. 6, 1295–1298 (2014).Google Scholar
19.Rojkiewicz, M., Kuś, P., Kozub, P., and Kempa, M.: The synthesis of new potential photosensitizers. Dye Pigment 99, 627–635 (2013).Google Scholar
20.Adarsh, N., Avirah, R.R., and Ramaiah, D.: Tuning photosensitized singlet oxygen generation efficiency of novel Aza-BODIPY dyes. Org. Lett. 12, 5720–5723 (2010).Google Scholar
21.Dayer, M.R., Movahedi, A.A.M. and Dayer, M.S.: Band Assignment in Hemoglobin Porphyrin Ring Spectrum: Using Four-Orbital Model of Gouterman. Protein Pept Lett 17, 473–479 (2010).Google Scholar
Supplementary material: File

Tsolekile et al. supplementary material 1

Tsolekile et al. supplementary material

Download Tsolekile et al. supplementary material 1(File)
File 1 MB