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Identification of proteins for controlled nucleation of metal-organic crystals for nanoenergetics

Published online by Cambridge University Press:  24 April 2019

Zachary E. Reinert ,
Chia-Suei Hung ,
Andrea R. Poole ,
Joseph M. Slocik ,
Marquise G. Crosby ,
Srikanth Singamaneni ,
Rajesh R. Naik ,
Patrick B. Dennis ,
Wendy J. Crookes-Goodson  and
Maneesh K. Gupta Open the ORCID record for Maneesh K. Gupta [Opens in a new window]
Zachary E. Reinert
Affiliation:
Materials and Manufacturing Directorate, Air Force Research Laboratory, Wright-Patterson Air Force Base, Ohio 45433, USA UES Inc., Dayton, Ohio 45432, USA
Chia-Suei Hung
Affiliation:
Materials and Manufacturing Directorate, Air Force Research Laboratory, Wright-Patterson Air Force Base, Ohio 45433, USA
Andrea R. Poole
Affiliation:
Materials and Manufacturing Directorate, Air Force Research Laboratory, Wright-Patterson Air Force Base, Ohio 45433, USA UES Inc., Dayton, Ohio 45432, USA
Joseph M. Slocik
Affiliation:
Materials and Manufacturing Directorate, Air Force Research Laboratory, Wright-Patterson Air Force Base, Ohio 45433, USA UES Inc., Dayton, Ohio 45432, USA
Marquise G. Crosby
Affiliation:
Materials and Manufacturing Directorate, Air Force Research Laboratory, Wright-Patterson Air Force Base, Ohio 45433, USA
Srikanth Singamaneni
Affiliation:
Department of Mechanical Engineering and Materials Science, Washington University, St. Louis, Missouri 63130, USA
Rajesh R. Naik
Affiliation:
711th Human Performance Wing, Air Force Research Laboratory, Wright-Patterson Air Force Base, Ohio 45433, USA
Patrick B. Dennis
Affiliation:
Materials and Manufacturing Directorate, Air Force Research Laboratory, Wright-Patterson Air Force Base, Ohio 45433, USA
Wendy J. Crookes-Goodson
Affiliation:
Materials and Manufacturing Directorate, Air Force Research Laboratory, Wright-Patterson Air Force Base, Ohio 45433, USA
Maneesh K. Gupta*
Affiliation:
Materials and Manufacturing Directorate, Air Force Research Laboratory, Wright-Patterson Air Force Base, Ohio 45433, USA
*
Address all correspondence to Maneesh K. Gupta at [email protected]
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Abstract

Here, we report that a marine sandworm Nereis virens jaw protein, Nvjp1, nucleates hemozoin with similar activity as the native parasite hemozoin protein, HisRPII. X-ray diffraction and scanning electron microscopy confirm the identity of the hemozoin produced from Nvjp1-containing reactions. Finally, we observed that nAl assembled with hemozoin from Nvjp1 reactions has a substantially higher energetic output when compared to analogous thermite from the synthetic standard or HisRPII-nucleated hemozoin. Our results demonstrate that a marine sandworm protein can nucleate malaria pigment and set the stage for engineering recombinant hemozoin production for nanoenergetic applications.

Type
Synthetic Biology Research Letters
Information
MRS Communications , Volume 9 , Issue 2 , June 2019 , pp. 456 - 463
Copyright
Copyright © Materials Research Society 2019 

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