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Fabrication of gelatin-poly(epichlorohydrin-co-ethylene oxide) fiber scaffolds by Forcespinning® for tissue engineering and drug release

Published online by Cambridge University Press:  24 October 2017

Narsimha Mamidi Open the ORCID record for Narsimha Mamidi [Opens in a new window] ,
Héctor Manuel Leija Gutiérrez ,
Javier Villela-Castrejón ,
Lucas Isenhart ,
Enrique V. Barrera  and
Alex Elías-Zúñiga
Narsimha Mamidi*
Affiliation:
Tecnológico de Monterrey, Campus Monterrey, School of Engineering and Science, Eugenio Garza Sada 2501 Sur, Col Tecnológico C.P. 64849, Monterrey, Nuevo León, México
Héctor Manuel Leija Gutiérrez
Affiliation:
Tecnológico de Monterrey, Campus Monterrey, School of Engineering and Science, Eugenio Garza Sada 2501 Sur, Col Tecnológico C.P. 64849, Monterrey, Nuevo León, México
Javier Villela-Castrejón
Affiliation:
Tecnológico de Monterrey, Centro de Biotecnología-FEMSA, School of Engineering and Science, Av. Eugenio Garza Sada 2501, Monterrey, N.L., C.P. 64849, México
Lucas Isenhart
Affiliation:
Department of Materials Science and NanoEngineering, Rice University, Houston, TX 77005, USA
Enrique V. Barrera
Affiliation:
Tecnológico de Monterrey, Campus Monterrey, School of Engineering and Science, Eugenio Garza Sada 2501 Sur, Col Tecnológico C.P. 64849, Monterrey, Nuevo León, México Department of Materials Science and NanoEngineering, Rice University, Houston, TX 77005, USA Department of Chemistry, Rice University, Houston, TX 77005, USA
Alex Elías-Zúñiga
Affiliation:
Tecnológico de Monterrey, Campus Monterrey, School of Engineering and Science, Eugenio Garza Sada 2501 Sur, Col Tecnológico C.P. 64849, Monterrey, Nuevo León, México
*
Address all correspondence to Narsimha Mamidi at [email protected]
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Abstract

Gelatin/poly(epichlorohydrin-co-ethylene oxide) [GL : PECO] composites are synthesized in a one-step process by the incorporation of elastic PECO and diclofenac. [GL : PECO] fibers are prepared by Forcespinning®. GL : PECO fibers are capable of diclofenac, by conjugation via a labile amide linkage. Fourier transform infrared spectroscopy (FTIR) results confirmed the chemical reactions and hydrogen bonds between gelatin, PECO, and diclofenac. Diclofenac drug release from GL : PECO fibers are measured for 15 days and prolonged drug release is observed. The cell viability is studied with NIH/3T3 and excellent results are observed. The sustained drug release and cytotoxicity results reveal that GL : PECO fibers could be promising substitutes for skin tissue engineering, wound healing, and drug delivery.

Type
Research Letters
Information
MRS Communications , Volume 7 , Issue 4 , December 2017 , pp. 913 - 921
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Copyright
Copyright © Materials Research Society 2017 

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