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Effects of nanoporous Au on ATP synthase

Published online by Cambridge University Press:  14 January 2020

Naoki Miyazawa ,
Masataka Hakamada  and
Mamoru Mabuchi
Naoki Miyazawa*
Affiliation:
Department of Materials Science and Engineering, School of Materials and Chemical Technology, Tokyo Institute of Technology, Nagatsuda-cho, Midori-ku, Yokohama226-8502, Japan
Masataka Hakamada
Affiliation:
Graduate School of Energy Science, Kyoto University, Yoshidahonmachi, Sakyo, Kyoto606-8501, Japan
Mamoru Mabuchi
Affiliation:
Graduate School of Energy Science, Kyoto University, Yoshidahonmachi, Sakyo, Kyoto606-8501, Japan
*
Address all correspondence to Naoki Miyazawa at [email protected]
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Abstract

Nanoporous Au shows the antimicrobial activity without the release of ROS. The cell wall is hyperpolarized by npAu. Hence, the hyperpolarized cell wall may affect ATP synthase, leading to the bacterial death. In the present work, the effects of the hyperpolarized cell wall on the structure and functions of Asp61 in ATP synthase are investigated by molecular dynamics simulations and first-principles calculations. The simulations suggest that the Asp61 is more negatively hyperpolarized, which is due to the strengthened O–H bond in Asp61, in interacting with the hyperpolarized cell wall, which results in the disturbance of proton transport in ATP synthase.

Type
Research Letters
Information
MRS Communications , Volume 10 , Issue 1 , March 2020 , pp. 173 - 178
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Copyright
Copyright © Materials Research Society 2020

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