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Development of forcespun fiber-aligned scaffolds from gelatin–zein composites for potential use in tissue engineering and drug release

Published online by Cambridge University Press:  10 May 2018

Narsimha Mamidi Open the ORCID record for Narsimha Mamidi [Opens in a new window] ,
Irasema Lopez Romo ,
Héctor Manuel Leija Gutiérrez ,
Enrique V. Barrera  and
Alex Elías-Zúñiga
Narsimha Mamidi*
Affiliation:
Tecnológico de Monterrey, Campus Monterrey, School of Engineering and Science, Eugenio Garza Sada 2501 Sur, Col Tecnológico C.P. 64849, Monterrey, Nuevo León, México
Irasema Lopez Romo
Affiliation:
Tecnológico de Monterrey, Centro de Biotecnología-FEMSA, School of Engineering and Science, Av. Eugenio Garza Sada 2501, Monterrey, N.L., C.P. 64849, México
Héctor Manuel Leija Gutiérrez
Affiliation:
Tecnológico de Monterrey, Campus Monterrey, School of Engineering and Science, Eugenio Garza Sada 2501 Sur, Col Tecnológico C.P. 64849, Monterrey, Nuevo León, México
Enrique V. Barrera
Affiliation:
Tecnológico de Monterrey, Campus Monterrey, School of Engineering and Science, Eugenio Garza Sada 2501 Sur, Col Tecnológico C.P. 64849, Monterrey, Nuevo León, México Department of Materials Science and NanoEngineering, Rice University, Houston, TX 77005, USA Department of Chemistry, Rice University, Houston, TX 77005, USA
Alex Elías-Zúñiga
Affiliation:
Tecnológico de Monterrey, Campus Monterrey, School of Engineering and Science, Eugenio Garza Sada 2501 Sur, Col Tecnológico C.P. 64849, Monterrey, Nuevo León, México
*
Address all correspondence to Narsimha Mamidi at [email protected]
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Abstract

In this study, based on the collection process, three-dimensional aligned fiber scaffolds from gelatin and zein protein were manufactured using Forcespinning®. The homogeneous blending of gelatin:zein (1:4) showed improved tensile and good hydrophobic properties (water contact angle of 115 °C). Cell viability, adhesion, proliferation, and drug release were measured. The cell viability was studied with human fibroblasts and a low cytotoxic effect was observed. Berberine drug release was measured and sustained release rate was observed over 15 days. The morphologic features, prolonged drug release, and cytotoxicity results suggest that these fibers could be appropriate for drug delivery and tissue engineering applications.

Type
Research Letters
Information
MRS Communications , Volume 8 , Issue 3 , September 2018 , pp. 885 - 892
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Copyright
Copyright © Materials Research Society 2018 

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