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Tunable neuronal scaffold biomaterials through plasmonic photo-patterning of aerogels

Published online by Cambridge University Press:  07 November 2019

Martina Rodriguez Sala ,
Chenhui Peng ,
Omar Skalli  and
Firouzeh Sabri
Martina Rodriguez Sala
Affiliation:
Department of Physics and Materials Science, University of Memphis, Memphis, TN38152, USA
Chenhui Peng*
Affiliation:
Department of Physics and Materials Science, University of Memphis, Memphis, TN38152, USA
Omar Skalli
Affiliation:
Department of Biological Sciences, University of Memphis, Memphis, TN38152, USA
Firouzeh Sabri*
Affiliation:
Department of Physics and Materials Science, University of Memphis, Memphis, TN38152, USA
*
Address all correspondence to Firouzeh Sabri at [email protected] and Chenhui Peng at [email protected]
Address all correspondence to Firouzeh Sabri at [email protected] and Chenhui Peng at [email protected]
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Abstract

The authors have shown recently that the neurite extension by neuronal PC12 cells is greatly impacted by aerogel topography. Indeed, the average neurite length of PC-12 cells grown on aerogels is greater than that in cells cultured on control substrates. Here, the authors report on the first experimental study focused on the design and development of a plasmonic photo-patterning technique for collagen-coated mesoporous aerogel biomaterials. Herein, the authors have produced specific patterns on silica aerogels by performing precise plasmonic photo-patterning on liquid crystal-coated aerogels. The authors report the methodology employed to create a collagen–liquid crystal gel mixture imprinted with precise plasmonic photo-patterns. PC12 cells plated on these patterns did attach and survive and followed the spatial cues of the pattern to align themselves in a similar pattern.

Type
Research Letters
Information
MRS Communications , Volume 9 , Issue 4 , December 2019 , pp. 1249 - 1255
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Copyright
Copyright © Materials Research Society 2019

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