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TiO2 hollow nanospheres functionalized with folic acid and ZnPc for targeted photodynamic therapy in glioblastoma cancer

Published online by Cambridge University Press:  14 November 2019

Minerva Uribe-Robles ,
Emma Ortiz-Islas ,
Ekaterina Rodriguez-Perez ,
Taehoon Lim  and
Alfredo A. Martinez-Morales
Minerva Uribe-Robles
Affiliation:
Materials Science and Engineering Program, University of California, Riverside, CA92521, USA College of Engineering Center for Environmental Research and Technology, University of California, Riverside, CA92507, USA
Emma Ortiz-Islas
Affiliation:
Nanotechnology Laboratory, National Institute of Neurology and Neurosurgery, Insurgentes sur 3877, Tlalpan, México City14269, Mexico
Ekaterina Rodriguez-Perez
Affiliation:
Neuroimmunoendocrinology Laboratory, National Institute of Neurology and Neurosurgery, Insurgentes sur 3877, Tlalpan, México City14269, Mexico
Taehoon Lim
Affiliation:
College of Engineering Center for Environmental Research and Technology, University of California, Riverside, CA92507, USA
Alfredo A. Martinez-Morales*
Affiliation:
Materials Science and Engineering Program, University of California, Riverside, CA92521, USA College of Engineering Center for Environmental Research and Technology, University of California, Riverside, CA92507, USA
*
Address all correspondence to Alfredo A. Martinez-Morales at [email protected]
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Abstract

Glioblastoma (GBM) is one of the most aggressive types of cancer which currently does not have a cure. Its invasive nature and heterogeneity makes its complete surgical removal impossible. Hence, a targeted treatment is critically needed to effectively eradicate this cancer. In this work, the authors report the synthesis of hollow TiO2 nanospheres (HTiO2NS) and their functionalization with folic acid (FA) and zinc (II) tetranitrophthalocyanine (ZnPc) to achieve cell selectivity and light absorption in the visible range. In vitro cytotoxicity of the functionalized HTiO2NS against M059K cell line (Human GBM cancer cells) was tested. In vitro generation of reactive oxygen species by HTiO2NS–FA–ZnPc nanostructures under UV irradiation was detected by fluorescence probing. To identify HTiO2NS–FA–ZnPc cell localization, the nanoparticles were labeled with fluorescein isothiocyanate dye and visualized by fluorescence microscopy. Results illustrate that HTiO2NS–FA–ZnPc nanostructures have the potential to be used for targeted photodynamic therapy for the treatment of GBM cancer.

Type
Research Letters
Information
MRS Communications , Volume 9 , Issue 4 , December 2019 , pp. 1242 - 1248
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Copyright
Copyright © Materials Research Society 2019

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