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On the cytotoxicity of a cationic tertiary amine PEGylated nanogel as nanocarrier for anticancer therapies

Published online by Cambridge University Press:  07 June 2018

Lizbeth A. Manzanares-Guevara ,
Angel Licea-Claverie Open the ORCID record for Angel Licea-Claverie [Opens in a new window] ,
Irasema Oroz-Parra  and
Alexei F. Licea-Navarro
Lizbeth A. Manzanares-Guevara
Affiliation:
Centro de Graduados e Investigación en Química, Instituto Tecnológico de Tijuana, Tijuana, Baja California, C.P. 22000, México
Angel Licea-Claverie*
Affiliation:
Centro de Graduados e Investigación en Química, Instituto Tecnológico de Tijuana, Tijuana, Baja California, C.P. 22000, México
Irasema Oroz-Parra
Affiliation:
Departamento de Innovación Biomédica, Centro de Investigación Científica y de Educación Superior de Ensenada (CICESE), Ensenada, Baja California, México Facultad de Ciencias Marinas, Universidad Autónoma de Baja California, Ensenada, Baja California, C.P. 22860, México
Alexei F. Licea-Navarro
Affiliation:
Departamento de Innovación Biomédica, Centro de Investigación Científica y de Educación Superior de Ensenada (CICESE), Ensenada, Baja California, México
*
Address all correspondence to Prof. Dr. Angel Licea-Claverie at [email protected]
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Abstract

Cationic PEGylated nanogels based on poly(N,N-diethylaminoethyl methacrylate) (PDEAEM) were prepared varying the ratio of PDEAEM to polyethyleneglycol (PEG), the initiator, and the crosslinker; resulting in nanogels of different surface charge (zeta-potential) and hydrodynamic diameter. Nanogels without PEG (100% PDEAEM) and nanogels containing 45 wt.% of PDEAEM were cytotoxic to human colon cancer cell line (HCT-116). Nanogels containing 20 wt.% or less of PDEAEM provided with a PEG shell were non-cytotoxic even at a concentration of 1 mg/mL. These nanogels loaded with 5-fluorouracil turned to be cytotoxic provoking cell death by apoptosis. Nanogels were also studied loaded with gold nanoparticles.

Type
Research Letters
Information
MRS Communications , Volume 8 , Issue 3 , September 2018 , pp. 1204 - 1210
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Copyright
Copyright © Materials Research Society 2018 

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