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High throughput fabrication of curcumin embedded gelatin-polylactic acid forcespun fiber-aligned scaffolds for the controlled release of curcumin

Published online by Cambridge University Press:  17 September 2018

Narsimha Mamidi Open the ORCID record for Narsimha Mamidi [Opens in a new window] ,
Irasema Lopez Romo ,
Enrique V. Barrera  and
Alex Elías-Zúñiga
Narsimha Mamidi*
Affiliation:
Tecnológico de Monterrey, Campus Monterrey, School of Engineering and Science, Eugenio Garza Sada 2501 Sur, Col Tecnológico C.P. 64849, Monterrey, Nuevo León, México
Irasema Lopez Romo
Affiliation:
Tecnológico de Monterrey, Centro de Biotecnología-FEMSA, School of Engineering and Science, Av. Eugenio Garza Sada 2501, Monterrey, N.L., C.P. 64849, México
Enrique V. Barrera
Affiliation:
Tecnológico de Monterrey, Campus Monterrey, School of Engineering and Science, Eugenio Garza Sada 2501 Sur, Col Tecnológico C.P. 64849, Monterrey, Nuevo León, México Department of Materials Science and NanoEngineering, Rice University, Houston, TX 77005, USA Department of Chemistry, Rice University, Houston, TX 77005, USA
Alex Elías-Zúñiga
Affiliation:
Tecnológico de Monterrey, Campus Monterrey, School of Engineering and Science, Eugenio Garza Sada 2501 Sur, Col Tecnológico C.P. 64849, Monterrey, Nuevo León, México
*
Address all correspondence to N. Mamidi at [email protected]
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Abstract

The aim of current study is to fabricate implantable curcumin embedded gelatin/polylactic acid/curcumin (GL/PLA/Cur) aligned fiber scaffolds by forcespinning®, which might have a potential application in drug delivery and cancer therapy. Fourier Transform Infrared Spectroscopy reveals the hydrogen bonding interactions between GL, PLA, and curcumin. In vitro curcumin drug release from GL/PLA/Cur fiber scaffolds is investigated and sustained release is observed over 15 days. Further, cell viability assay reveals that GL/PLA/Cur aligned fibers show excellent growth of human fibroblast cells. These results strongly suggest that the curcumin bearing GL/PLA/Cur composite fibers may show the potential application in cancer therapy, drug delivery, and wound dressing.

Type
Research Letters
Information
MRS Communications , Volume 8 , Issue 4 , December 2018 , pp. 1395 - 1403
Copyright
Copyright © Materials Research Society 2018 

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