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Colon cancer cells adhesion on polymeric nanostructured surfaces

Published online by Cambridge University Press:  11 December 2017

Angelo Accardo Open the ORCID record for Angelo Accardo [Opens in a new window] ,
Victoria Shalabaeva  and
Rosanna La Rocca
Angelo Accardo*
Affiliation:
LAAS-CNRS, Université de Toulouse, CNRS, 7 Avenue du Colonel Roche, Toulouse, F-31400, France
Victoria Shalabaeva
Affiliation:
Istituto Italiano di Tecnologia, Via Morego 30, Genova, 16163, Italy
Rosanna La Rocca
Affiliation:
Istituto Italiano di Tecnologia, Via Morego 30, Genova, 16163, Italy
*
Address all correspondence to Angelo Accardo at [email protected]
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Abstract

In this work, we report on the adhesion of HCT116 (human colon carcinoma cells) cultured on nanofibrillar polymethylmethacrylate (PMMA) and SU-8 micropillars substrates. Both surfaces enabled a good cell proliferation and promoted the formation of adherent interconnections with the fabricated nano- and microstructures. The three-dimensional immunofluorescence confocal characterization of the cells on nanotextured PMMA highlighted the expression of well-spread F-actin cytoskeletal networks as well as the presence of focal adhesions. This study provides thus interesting perspectives for further investigations on the force/adhesion mechanisms related to cancer cell growth and proliferation.

Type
Research Letters
Information
MRS Communications , Volume 8 , Issue 1 , March 2018 , pp. 35 - 39
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Copyright
Copyright © Materials Research Society 2017 

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