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Biomaterial-based strategies for the engineering of mechanically active soft tissues

Published online by Cambridge University Press:  26 March 2012

Zhixiang Tong  and
Xinqiao Jia
Zhixiang Tong
Affiliation:
Department of Materials Science and Engineering, Biomedical Engineering Program, Delaware Biotechnology Institute, University of Delaware, Newark, Delaware 19716
Xinqiao Jia*
Affiliation:
Department of Materials Science and Engineering, Biomedical Engineering Program, Delaware Biotechnology Institute, University of Delaware, Newark, Delaware 19716
*
Address all correspondence to Xinqiao Jia at [email protected]
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Abstract

Load-bearing, mechanically active tissues are routinely subjected to nonlinear mechanical deformations. Consequently, these tissues exhibit complex mechanical properties and unique tissue organizations. Successful engineering of mechanically active tissues relies on the integration of the mechanical sensing mechanism found in the native tissues into polymeric scaffolds. Intelligent biomaterials that closely mimic the structural organizations and multi-scale responsiveness of the natural extracellular matrices, when strategically combined with multipotent cells and dynamic culture devices that generate physiologically relevant physical forces, will lead to the creation of artificial tissues that are mechanically robust and biologically functional.

Type
Prospectives Articles
Information
MRS Communications , Volume 2 , Issue 2 , June 2012 , pp. 31 - 39
Copyright
Copyright © Materials Research Society 2012

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