High-temperature materials for structural applications. Advances in metallurgy and metal mixology, together with high-performance computing, high-resolution micro-scopy, and advanced spectroscopy methods, reveal the potential of multicomponent advanced metals, such as multicomponent bulk metallic glasses and advanced high-entropy alloys for high-temperature structural applications. This issue of MRS Bulletin overviews the progress and directions for these multicomponent alloys for high-temperature structural applications. The cover shows the microstructure of a Ni44Co15Cr12Fe13Al10Ti6 precipitation-hardened high-entropy alloy after aging, showing high-density L12-type precipitates embedded in a fcc matrix. The high-entropy approach provides new opportunities for obtaining preferred precipitate size, morphological shape, and composition, as well as tailoring lattice misfit between the matrix and the precipitation, important for high-temperature applications. Image courtesy of Boxuan Cao, City University of Hong Kong. See the technical theme that begins on page 847.