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Quasi-Steady Flow Dynamics Study of Human Aortic Valve with Numerical Techniques

Published online by Cambridge University Press:  16 October 2012

H.-H. Vu  and
C.-H. Hsu
H.-H. Vu
Affiliation:
Department of Mechanical Engineering, National Kaohsiung University of Applied Sciences, Kaohsiung, Taiwan 80778, R.O.C.
C.-H. Hsu*
Affiliation:
Department of Mold and Die Engineering, National Kaohsiung University of Applied Sciences, Kaohsiung, Taiwan 80778, R.O.C.
*
* Corresponding author ([email protected])
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Abstract

Human aortic valve is made of thin collagen type tissue. The three leaflets open and close under fluid forces exerted upon them. To simulate the hemodynamic characteristics of the blood flow, ANSYS CFX10.0 software was utilized to analyze the three-dimensional Reynolds-averaged Navier-Stokes equations. With a quasi-steady analysis model, we predict values of the blood velocity and the wall shear stress both over the valve leaflets and the endothelial lining. In addition, investigation on fluid dynamic of a heart valve supposed suffering prolapsed disease has been also conducted, and compared with normal valve. Analysis results highlight that leaflet opening situation and valve geometry affect the shear stress distribution and vortex flow regime. Maximum shear stress takes place near the center of leaflet trailing edge at the very beginning of systolic phase with value of 7.093N/m2. At peak systole, the maximum wall shear stress distributes near the aortic root where jet impingement takes place. Current study also demonstrated the interactive impact between low and high wall shear stress on relation to heart valve disease.

Keywords

Aortic valveHemodynamic characteristicsWall shear stressProlapsed disease
Type
Articles
Information
Journal of Mechanics , Volume 28 , Issue 4 , December 2012 , pp. 637 - 646
Copyright
Copyright © The Society of Theoretical and Applied Mechanics, R.O.C. 2012

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References

REFERENCES

1.Gimbrone, M. A., Nagel, T. and Topper, J. N., “Biomechanical Activation: An Emerging Paradigm in Endothelial Adhesion Biology,” Journal of Clinical Investigation, 99, pp. 1809–1813 (1997).Google Scholar
2.Gimbrone, M. A., Topper, J. N., Nagel, T., Anderson, K. R. and Garcia-Cardena, G., “Endothelial Dysfunction, Hemodynamic Forces, and Atherogenesis,” Annals of the New York Academy of Sciences, 902, pp. 230–240 (2000).Google Scholar
3.Traub, O. and Berk, B. C., “Laminar Shear Stress: Mechanisms by Which Endothelial Cells Transduce an Atheroprotective Force,” Arteriosclerosis, Thrombosis and Vascular Biology, 18, pp. 677–685 (1998).Google Scholar
4.Chien, S., Li, S. and Shyy, Y. J., “Effects of Mechanical Forces on Signal Transduction and Gene Expression in Endothelial Cells,” Hypertension, 31, pp. 162–169 (1998).Google Scholar
5.Akutsu, T. and Saito, J., “Dynamic Particle Image Velocimetry Flow Analysis of the Flow Field Immediately Downstream of Bileaflet Mechanical Mitral Prostheses,” Journal of Artificial Organs, 9, pp. 165–178 (2006).Google Scholar
6.Lee, H., Tatsumi, E., Homma, A., Tsukiya, T. and Taenaka, Y., “Mechanism for Cavitation of Monoleaflet and Bileaflet Valves in an Artificial Heart,” Journal of Artificial Organs, 9, pp. 154–160 (2006).Google Scholar
7.Ge, L., Jones, S. C., Sotiropoulos, F., Healy, T. M. and Yoganathan, A. P., “Numerical Simulation of Flow in Mechanical Heart Valves: Grid Resolution and the Assumption of Flow Symmetry,” ASME Transaction: Journal of Biomechanical Engineering, 125, pp. 709–718 (2003).Google Scholar
8.Kortsmit, J., Driessen, N. J. B., Rutten, M. C. M. and Baaijens, F. P. T., “Real Time, Non-Invasive Assessment of Leaflet Deformation in Heart Valve Tissue Engineering,” Annals of Biomedical Engineering, 37, pp. 532–541 (2009).Google Scholar
9.Sun, W., Abad, A. and Sacks, M. S., “Simulated Bioprosthetic Heart Valve Deformation Under Quasi-Static Loading,” ASME: Journal of Biomechanical Engineering, 127, pp. 905–914 (2005).Google Scholar
10.Haj-Ali, R., Dasi, L. P., Kim, H. S., Choi, J., Leo, H. W. and Yoganathan, A. P., “Structural Simulations of Prosthetic Tri-Leaflet Aortic Heart Valves,” Journal of Biomechanics, 41, pp. 1510–1519 (2008).Google Scholar
11.Sacks, M. S. and Yoganathan, A. P., “Heart Valve Function: A Biomechanical Perspective,” Philosophy Transactions of the Royal Society B, 362, pp. 1369–1391 (2007).Google Scholar
12.Swanson, W. M. and Clark, R. E., “Aortic Valve Leaflet Motion During Systole,” Circulation Research, 32, pp. 42–48 (1973).CrossRefGoogle ScholarPubMed
13.Hsu, C. H., “A Visualization Design Environment for Quick Designs of Prosthetic Mechanical Heart Valves,” Ph.D. Thesis, Department of Mechanical Engineering, Leeds University, U.K. (1995).Google Scholar
14.Swanson, W. M. and Clark, R. E., “Dimensions and Geometric Relationships of the Human Aortic Value as a Function of Pressure,” Circulation Research, 35, pp. 871–882 (1974).Google Scholar
15.Walker, P. G. and Yoganathan, A. P., “In Vitro Pulsatile Flow Hemodynamics of Five Mechanical Aortic Heart Valve Prostheses,” European Journal of Cardio-thoracic Surgery, 6, pp. s113–123 (1992).Google Scholar
16.Launder, B. E. and Spalding, D. B., “The Numerical Computation of Turbulent Flows,” Computer Methods in Applied Mechanics and Engineering, 3, pp. 269–289 (1974).Google Scholar
17.Patankar, S. V., Numerical Heat Transfer, Hemisphere, Washington, D.C. (1980).Google Scholar
18.Prakash, C. and Patankar, S. V., “A Control Volume Based Finite Element Method for Solving the Navier-Stokes Equations Using Equal Order Velocity- Pressure Interpolation,” Numerical Heat Transfer, 8, pp. 259–280 (1985).Google Scholar
19.ACC/AHA Pocket Guideline, “Management of Patients with Valvular Heart Disease,” American College of Cardiology Foundation, American Heart Association, Inc, pp. 17–18 (2006).Google Scholar
20.King, M., David, T. and Fisher, J., “An Initial Parametric Study on Fluid Flow Through Bileaflet Mechanical Heart Valves, Using Computational Fluid Dynamics,” Journal of Engineering in Medicine, 208, pp. 63–72 (1994).Google Scholar
21.Yoganathan, A. P., Woo, Y. R. and Hsing, W. S., “Turbulent Shear Stress Measurements in the Vicinity of Aortic Valve Prostheses,” Journal of Biomechanics, 19, pp. 433–442 (1986).Google Scholar
22.Fry, D. L., “Acute Vascular Endothelial Changes Associated with Increased Blood Velocity Gradients”, Circulation Research, 12, pp. 165–197 (1968).CrossRefGoogle Scholar
23.Chandran, K. B., Yoganathan, A. P. and Rittgers, S. E., Biofluid Mechanics – The Human Circulation, Taylor & Francis Group, LLC (2007).Google Scholar
24.Van Loon, R., “Towards Computational Modeling of Aortic Stenosis,” International Journal of Numerical Methods Biomedical Engineering, 26, pp. 405–420 (2010).Google Scholar
25.Korakianitis, T. and Shi, Y., “Numerical Simulation of Cardiovascular Dynamics with Healthy and Diseased Heart Valve,” Journal of Biomechanical, 39, pp. 1964–1982 (2006).Google Scholar