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Enhanced bone regeneration of zirconia-toughened alumina nanocomposites using PA6/HA nanofiber coating via electrospinning

Published online by Cambridge University Press:  26 November 2018

Hamid Esfahani Open the ORCID record for Hamid Esfahani [Opens in a new window] ,
Mahsa Darvishghanbar  and
Behzad Farshid
Hamid Esfahani*
Affiliation:
Department of Materials Engineering, Bu-Ali Sina University, Hamedan 65178-38695, Iran
Mahsa Darvishghanbar
Affiliation:
Department of Materials Engineering, Bu-Ali Sina University, Hamedan 65178-38695, Iran
Behzad Farshid
Affiliation:
Materials Science & Chemical Engineering Department, Stony Brook University, Stony Brook, New York 11794-2275, USA
*
a)Address all correspondence to this author. e-mail: [email protected]
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Abstract

In this study, the bioactivity and cytocompatibility of electrospun polyamide 6 (PA6)/hydroxyapatite (HA) coating on zirconia-toughened alumina (ZTA) were investigated. Adjusting the PA6/HA ratio to 1.15 (w/w) had a significant role in achieving an appropriate fibrous coating with an average diameter of 120 ± 10 nm and surface porosity of 64.3%. The surface of bare and coated samples was hydrophilic, which promoted bone regeneration. The adhesion test of the PA6/HA mat demonstrated that a cohesive coating was formed on the ZTA via electrospinning. The in vitro bioactivity test of the PA6/HA coating in simulated body fluid (SBF) corroborated the formation of a nanostructured bonelike apatite phase. Cytocompatibility of the samples was evaluated through in vitro osteosarcoma-like cell (MG63) culture assays. The cytotoxicity study showed that the electrospun PA6/HA coating significantly improved cell attachment and spreading. The development of such bioactive, biomedical coatings opens new avenues for bone tissue engineering applications.

Keywords

bonefibernanostructure
Type
Article
Information
Journal of Materials Research , Volume 33 , Issue 24 , 28 December 2018 , pp. 4287 - 4295
Copyright
Copyright © Materials Research Society 2018 

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References

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