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The delayed degradation mechanism and mechanical properties of β-TCP filler in poly(lactide-co-glycolide)/beta-tricalcium phosphate composite suture anchors during short-time degradation in vivo

Published online by Cambridge University Press:  12 November 2018

You-Ran Luo Open the ORCID record for You-Ran Luo [Opens in a new window] ,
Li Zhang ,
Cheng Chen ,
Dong-Yuan Sun ,
Peng Wu ,
Yue Wang ,
Yun-Mao Liao ,
Xiao-Yan Cao ,
Cheng-Kung Cheng  and
Zi-Qing Tang
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You-Ran Luo
Affiliation:
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
Li Zhang
Affiliation:
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
Cheng Chen
Affiliation:
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
Dong-Yuan Sun
Affiliation:
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
Peng Wu
Affiliation:
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
Yue Wang
Affiliation:
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
Yun-Mao Liao
Affiliation:
State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China
Xiao-Yan Cao
Affiliation:
Beijing Advanced Innovation Centre for Biomedical Engineering, Beihang University, Beijing 100191, China
Cheng-Kung Cheng
Affiliation:
Beijing Advanced Innovation Centre for Biomedical Engineering, Beihang University, Beijing 100191, China
Zi-Qing Tang*
Affiliation:
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
Xing Liang*
Affiliation:
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
*
a)Address all correspondence to these authors. e-mail: [email protected]
b)e-mail: [email protected]
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Abstract

The aim of this study was to investigate the in vivo degradation mechanism and the mechanical properties of poly(lactide-co-glycolide)/beta-tricalcium phosphate (PLGA/β-TCP) composite anchors. Anchors composed of PLGA and β-TCP were implanted in the dorsal subcutaneous tissue of beagle dogs for 6, 12, 16, and 26 weeks. The degradation of the materials was evaluated by measuring the changes in thermal behavior, crystallinity, and mechanical properties. Scanning electron microscope (SEM) was used to observe the surface and longitudinal section of the material. The evaluation of mechanical strength retention and degradation properties suggest that the addition of β-TCP particles efficiently enhances their mechanical properties and thermal characteristics and delays their degradation rate. By analyzing the results of SEM, X-ray diffraction, and differential scanning calorimetry, we can infer that after 12 weeks, the connection between β-TCP and PLGA becomes less compact, which accelerates the decline of mechanical strength.

Keywords

compositeX-ray diffractioncrystalline
Type
Article
Information
Journal of Materials Research , Volume 33 , Issue 24 , 28 December 2018 , pp. 4278 - 4286
Copyright
Copyright © Materials Research Society 2018 

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Footnotes

c)

These authors contributed equally to this work.

References

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