Hostname: page-component-586b7cd67f-t7czq Total loading time: 0 Render date: 2024-11-29T15:06:38.825Z Has data issue: false hasContentIssue false

A method for preparation of fibrin glue

Published online by Cambridge University Press:  29 June 2007

L. H. Durham*
Affiliation:
Department of Otorhinolaryngology, Walton Hospital.
D. J. Willatt
Affiliation:
Department of Otorhinolaryngology, Walton Hospital.
M. W. Yung
Affiliation:
Department of Otorhinolaryngology, Walton Hospital.
I. Jones
Affiliation:
Department of Haematology, Walton Hospital.
P. A. Stevenson
Affiliation:
Department of Haematology, Walton Hospital.
M. F. Ramadan
Affiliation:
Department of Otorhinolaryngology, Walton Hospital.
*
Mr. L. H. Durham, Department of Otorhinolaryngology, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF.

Abstract

Otorhinolaryngological operations would be facilitated by the use of a safe, cheap, surgical adhesive. Though commercial fibrin glue is effective, it is both relatively expensive and, because it is prepared from pooled human blood, there has been concern that it carries the risk of transmitting viral disease, in particular hepatitis and acquired immune deficiency syndrome. We describe a rapid, cheap method of preparing sufficient fibrin glue, of adequate bonding power, from a small quantity of the patient's own blood, and therefore with no risk of contracting viral disease. Our method of preparation of fibrin glue promises to provide a valuable adjunct to otorhinolaryngological surgical practice.

Type
Research Article
Copyright
Copyright © JLO (1984) Limited 1987

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Gestring, G. F. and Lerner, R. (1983) Autologous fibrinogen for tissue adhesion, haemostasis, and embolisation. Vascular Surgery, 17: 294304.CrossRefGoogle Scholar
Harker, L. A. and Slichter, S. J. (1972) Platelet and fibrinogen consumption in man. New England Journal of Medicine, 287: 9991005.CrossRefGoogle ScholarPubMed
O'Conner, A. F. and Shea, J. J. (1982) A biologic adhesive for otologic practice. Otolaryngology—Head and Neck Surgery, 90: 347348.Google Scholar
Panis, R. (1982) Human fibrinogen tissue adhesive, a new tool in middle ear surgery. Journal of Head and Neck Pathology, 3: 9495.Google Scholar
Siedentop, K. H., Harris, D. M. and Loewy, A. (1983) Experimental use of fibrin tissue adhesive in middle ear surgery. Laryngoscope, 93: 13101313.CrossRefGoogle ScholarPubMed
Staindl, O. (1979) Tissue adhesion with highly concentrated human fibrinogen in otolaryngology. Annals of Otology, Rhinology and Laryngology, 88: 413– 418.CrossRefGoogle ScholarPubMed
Takeda, Y. (1966) Studies of the metabolism and distribution of fibrinogen in healthy men and autologous 125 I-labeled fibrinogen. Journal of Clinical Investigation, 45: 103111.CrossRefGoogle Scholar
Wingand, M. E. and Panis, R. (1981) Fibrin glue in microsurgery of the middle ear. Clinical Otolaryngology, 6: 127.CrossRefGoogle Scholar
Wolf, G. (1983) Der konzentrierte autologe gewebekleber. Archives of Otorhinolaryngology, 237: 279283.CrossRefGoogle Scholar