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The effect of resveratrol in cardio-metabolic disorders during pregnancy and offspring outcomes: a review

Published online by Cambridge University Press:  09 June 2022

Diego Cabral Lacerda Open the ORCID record for Diego Cabral Lacerda [Opens in a new window] ,
Paulo César Trindade Costa ,
Yohanna de Oliveira  and
José Luiz de Brito Alves Open the ORCID record for José Luiz de Brito Alves [Opens in a new window]
Diego Cabral Lacerda
Affiliation:
Department of Nutrition, Health Sciences Center, Federal University of Paraíba, João Pessoa, Brazil
Paulo César Trindade Costa
Affiliation:
Department of Nutrition, Health Sciences Center, Federal University of Paraíba, João Pessoa, Brazil
Yohanna de Oliveira
Affiliation:
Department of Nutrition, Health Sciences Center, Federal University of Paraíba, João Pessoa, Brazil
José Luiz de Brito Alves*
Affiliation:
Department of Nutrition, Health Sciences Center, Federal University of Paraíba, João Pessoa, Brazil
*
Address for correspondence: José Luiz DE Brito Alves, PhD, Federal University of Paraiba, Department of Nutrition, Campus I – Jd. Cidade Universitária, João Pessoa, CEP: 58051-900, PB, Brazil. Email: [email protected]
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Abstract

Resveratrol supplementation during pregnancy and lactation has been associated with a reduced risk of maternal obesity, gestational diabetes mellitus , and preeclampsia. In addition, emerging evidence has shown that maternal resveratrol supplementation diminishes cardio-metabolic disorders in offspring, highlighting its role in modulating adaptative responses involving phenotypical plasticity. Therefore, it is reasonable to infer that administration of resveratrol during pregnancy and lactation periods could be considered an important nutritional intervention to decrease the risk of maternal and offspring cardio-metabolic disorders. To highlight these new insights, this literature review will summarize the understanding emerging from experimental and clinical studies about resveratrol supplementation and its capacity to prevent or minimize maternal and offspring cardio-metabolic disorders.

Keywords

Pregnancy complicationsmetabolic diseasespolyphenolsresveratrol
Type
Review
Information
Journal of Developmental Origins of Health and Disease , Volume 14 , Issue 1 , February 2023 , pp. 3 - 14
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Copyright
© The Author(s), 2022. Published by Cambridge University Press in association with International Society for Developmental Origins of Health and Disease

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