Hostname: page-component-cd9895bd7-p9bg8 Total loading time: 0 Render date: 2024-12-23T14:03:57.844Z Has data issue: false hasContentIssue false

An inherited arginase deficiency in sheep erythrocytes

Published online by Cambridge University Press:  27 March 2009

Elizabeth M. Tucker
Affiliation:
A.R.C. Institute of Animal Physiology, Babraham, Cambridge CB2 4JLT, U.K.

Extract

Arginase (EC 3.5.3.1) catalyses the conversion of arginine to ornithine and urea, and is a key enzyme of the urea cycle. The enzyme is present in high activity in various mammalian red cells (Nishibe, 1973, 1974; Owczarczyk & Barej, 1975) and inherited arginase deficiencies have been found in two primate species (Shih et al. 1972; Terheggen, Lavinha & Colombo, 1972). The present paper describes an inherited arginase deficiency in the erythrocytes of certain sheep.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1977

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Archer, R. K. (1965). In Haematological Techniques for Use on Animals, pp. 60–3. Oxford: Blackwell Scientific Publications.Google Scholar
Nishibe, H. (1973). Isolation and characterization of arginase in human erythrocytes. Physiological Chemistry and Physics 5, 453–62.Google Scholar
Nishibe, H. (1974). Urea cycle enzymes in human erythrocytes. Clinica Chimica Acta 50, 305–10.CrossRefGoogle Scholar
Owczarczyk, B. & Babej, W. (1975). The different activities of arginase, arginine synthetase, ornithine transcarbamylase and 5-ornithine transaminase in the liver and blood cells of some farm animals. Comparative Biochemistry and Physiology 50B, 555–8.Google Scholar
Shih, V. E., Jones, T. C., Levy, H. L. & Madigan, P. M. (1972). Arginase deficiency in Macaca fascicularis. I. Arginase activity and arginine concentration in erythrocytes and liver. Pediatric Research 6, 548–51.CrossRefGoogle Scholar
Terheogen, H. G., Lavinha, F. & Colombo, J. P. (1972). Familial hyperargininemia. Journal de Oenetique Humaine 20, 6984.Google Scholar