Objectives: To evaluate the impact of AI-technology implementation into the algorithm for assessing completed tasks of the online SAGE test to identify primary cognitive changes.

In order to raise awareness among Russians about dementia and early diagnosis to reduce the risk of occurrence and development of the syndrome, the Nodementia.net project improved the online SAGE test as a convenient self-testing tool for cognitive changes. The visual- constructive and executive skills tasks in SAGE-testing required enhancement of the evaluation algorithm by the AI implementation. AI-technology is designed to highly accurately evaluate human drawings against given criteria and assign scores that correspond to the user’s cognitive status.

Methods: In the process of improving the test, project experts explored and compared drawing evaluation services, but none satisfied the criteria. In order to create a fundamentally new AI model, experts analyzed 10,000 pictures and prepared algorithms to train the experimental AI model. As a result, the project specialists created AI model that evaluates pictures with 80% accuracy and implemented it into online test on the Nodementia.net website.

Results: To train the fundamentally new AI model, experts analyzed more than 10,000 different images, which helped to form the evaluation logic, taking into account the shape of the picture, color, line curvature, accuracy of image repetition and more than 100 other factors. Currently, the AI model correctly evaluates about 80% of images; the next step is 95%. We have improved the mechanism for assessing tasks, reduced biases and increased the amount of users.

Conclusions: To improve testing algorithms and increase the accuracy of online SAGE test results, we integrated pattern recognition technology based on a self-learning AI model. We used more than 10,000 different images for initial training, based on which the AI generated more than 100 evaluation criteria. Now the AI is expanding its library of “knowledge” and thereby honing its assessment skills, becoming an integral part of our unique online test.

Key words: AI implementation; online SAGE test; dementia; Alzheimer’s disease

Objectives: Effectiveness of psychotherapy depends on patients’ adherence to between-session homework (HW) to practice therapeutic skills. mHealth apps can offer continuing reminders, although frequent reminders overwhelm or burden patients and therefore are ineffective. Predicting likelihood of completing daily HW and sending contextual reminders has the potential to improve HW adherence and therefore improvesymptoms.

Methods: Depressed older participants (N = 51) undergoing psychotherapy provided daily active ratings on mood, anhedonia, stress and pain via an mHealth app. Data on activity, mobilization, sociability and sleep passively were also recorded via device sensors (e.g., microphone, accelerometer, GPS etc.). Using active and passive mHealth data, we developed predictive models of daily home-work completion status using a naïve semi-supervised deep learning algorithm. Prediction accuracy was determined via time-dependent cross-validation.

Results: Study participants had a mean (SD) age of 71.4 (7.76) years, mean (SD) of 14.9 (2.93) years of education, mean (SD) BIS/BAS total of 22.6 (3.36), mean (SD) MADRS total score of20.4 (6.04) and 88.2% were of female gender, 29.4% were single, 83.8% were of non-Hispanic ethnicity, 58.8% belonged to Caucasian race and 38.2% practiced Catholic religion. With 4700 person-days HW completion response, our models show an AUC of 84.7% (sensitivity = 76.2%; specificity = 80%) estimated by cross-validation.

Conclusions: This paper demonstrates the feasibility of predicting adherence to psychotherapy in depressed older adults using actively and passively collected mHealth data. Digital interventions based on such predictive models can potentially increase adherence to psychotherapy and thereby improve its effectiveness without increasing the user notification burden.

Objectives: The aim of this study was to analyze the impact of maintaining professional activity on cognitive functioning at advanced ages.

Methods: The sample comprised 131 people aged 60 years-old and older (M = 68,15 years) of whom 41 were still working (30 women and 11 men, Mage = 65.24), and 89 retired (74 women and 15 men Mage = 69.48). To assess participants’ cognitive functioning the following instruments were used: Rey-Osterrieth Complex Figure Test, Digit Span Test, Trail Making Test (TMT), Verbal Fluency Test and Boston Naming Test (Short Form). Since age differences among participants of the two groups were found an ANCOVA test was used, and age was included as a covariable.

Results: Statistically significant differences were found between the two groups in the Part A of TMT (F = 7.383, p < 0.05) and the Boston Naming Test (Short Form) (F = 3.495, p < 0.05). Compared with retired participants those who were still active had better scores on both measures.

Conclusions: Work-related activity in old age has a positive influence on cognitive functioning and can contribute to older people’s cognitive reserve and to maintaining better attention, naming or word retrieval performance. Thus, in order to maintain good cognitive functioning, when older adults retire, they may need to substitute work with stimulating and challenging activities.

Objectives: The aim of this study was to ascertain the influence of a six-month multidomain stimulation program on cognitive functioning.

Methods: The sample comprised 25 older adults 60 years-old and older (Mage = 66.08 years), of whom 96% were women and 54% had high education. The intervention program had a duration of six months and was implemented in a group format in one-hour sessions on a weekly basis. Lessons on neuroprotective factors, training in practical compensatory strategies to improve daily performance, cognitive training exercises and recreational cognitive stimulation activities were included. In order to analyze participants’ cognitive functioning the following instruments were used: Mini-Mental State Examination, Rey Complex Figure Test, Digit Span Test, Stroop Test, Trail Making Test (Part A and Part B), Verbal Fluency Test, Boston Naming Test (Short Form) and Neuropsi Verbal Memory Subtest. Wilcoxon test was performed to test the impact of the intervention program on participants cognitive functioning.

Results: Statistically significant differences were found after the six-month intervention in verbal memory encoding (W= –2.772, p< 0.05), in spontaneous verbal memory retrieval(freerecall) (W= – 3.456, p< 0.001), inverbal recognition memory (W = –3.184, p < 0.001), in spontaneous visual memory retrieval (W = –2.056, p < 0.05), and in naming by visual confrontation (W = –2.521, p < 0.05). In all cases, participants increased their scores after taking part in multicomponent a six-month multidomain stimulationprogram

Conclusions: One of the biggest concerns among older people is the loss of cognitive abilities that may occur with ageing. Cognitive stimulation programs, if sufficiently comprehensive, can be a good tool to maintain and improve cognitive functions as we age.

Objectives: To discuss a proposal for a cognitive behavioral psychotherapy protocol for people with Mild Cognitive Impairment and Mild Behavioral Impairment framed within psychosocial treatments.

Methods: The lack of a specific psychotherapy protocol in Latin America for the selected population will be presented, as well as the need to complement cognitive stimulation treatment with cognitive behavioral psychotherapy for the corresponding cases. The literature explored in this theoretical framework will be addressed and the steps to follow in the aforementioned project will be proposed.

Results: Currently, there are two main intervention pathways for MCI and DM, known as pharmacological and psychosocial treatments. The latter become indispensable when considering them as multicausal and multidimensional pathologies and psychological treatments are part of them (Berriel and Fernández, 2007). Psychotherapy in particular allows patients to deal with behavioral changes and the experience related to the disease in a more functional way in the long term (Linnemann and Fellgiebel, 2017). However, there are few studies that address evidence-based psychotherapeutic interventions. Even in Latin America, there are no reports of protocols that can be generalized for application in clinical practice. Faced with this absence, the project of developing a specific cognitive behavioral psychotherapy protocol for this population isframed.

Conclusions: There are few studies that address evidence-based psychotherapeutic interventions, and there are not even reports of generalizable protocols in Latin America. In light of this absence, a project is underway to develop a specific cognitive behavioral psychotherapy protocol for this population based on the limited evidence, extensive clinical experience and adapted to the preferences and needs of the localpopulation.

Background: The older adult population is growing in many countries worldwide, consistent with the aging of the vast baby-boom cohort. Older men have high rates of suicide in their post-retirement years, necessitating research investigating mental health promotion and suicide prevention in the peri-retirementperiod.

Methods: Secondary analyses were conducted of pre-group data from 83 participants in a study of Meaning- Centered Men’s Groups (MCMG; Heisel et al, 2020), an upstream community-based psychological intervention group for men over 55 facing the transition to retirement. Eligible participants met with investigators in an academic health sciences centre and completed measures of retirement satisfaction (RS), suicide ideation, and positive (e.g., psychological well-being, perceived social support, and life satisfaction) and negative psychological factors (e.g., depression, hopelessness, loneliness, and anxiety) prior to the start of a 12-week course of MCMG. Associations were investigated among measures of retirement satisfaction and the positive and negative psychological factors. RS was predicted to be positively associated with the positive psychological variables, and negatively associated with the negative psychological variables. We specifically predicted that RS would be negatively associated with suicide ideation, and that this association would be mediated by depressive symptom severity.

negative psychological factors in the expected direction. Retirement dissatisfaction was significantly associated with suicide ideation (Geriatric Suicide Ideation Scale or GSIS), and particularly so with items assessing a perceived Loss of Personal and Social Worth. The association between RS and suicide ideation was significantly mediated by depressive symptom severity (Geriatric Depression Scale).

Conclusions: Retirement satisfaction is closely associated with self-reported mental health and well-being variables among middle-aged and older men facing the transition to retirement. Severe dissatisfaction with retirement may be a suicide risk indicator, necessitating investigation and potential intervention. These and other findings will be discussed in the context of the importance of meaningful engagement in one’s post-employment years.

Key Words: suicide ideation; retirement satisfaction; upstream interventions; meaning in life

Objectives: Apart from irrational polypharmacy, drug-drug interactions (DDIs) and potentially inappropriate medications for elderly patients, there are numerous challenges referring to psychopharmacological treatment in this patient subgroup prescribed psychotropic agents. Specifically, pharmacokinetics and pharmacodynamics essentially differ in elderly patients, complicating medication selection and dosing.

Methods: Pharmacokinetics involves absorption, distribution, metabolism, and elimination of the medication. Elderly patients often present distinct patterns of medication absorption as well as reduced elimination (due to decreased kidney function). DDIs are another major confounder of medication metabolism. This is particularly

common in elderly patients, as one out of two elderly patients with mental disorders receive polypharmacy which in turn requires careful dose adjustment. Medication adherence is an additional challenge in patients with mental disorders, further complicating pharmacotherapy.

Results: We discuss the benefits of therapeutic drug monitoring (TDM), i.e. the regular measuring of drug concentrations in plasma of patients prescribed psychotropic agents. TDM is a valuable personalized treatment tool; specifically, it allows the determination of the minimum effective dosage also improving safety outcomes. Basic TDM principles, such as steady-state, trough levels and therapeutic reference ranges in the context of elderly patients’ pharmacological treatment will be discussed.

Discussion: The use of TDM is of established clinical value in particularly vulnerable patient subgroups such as elderly patients. Summarizing practical recommendations for TDM in clinical routine we aim to enhance its use ultimately enabling an improvement of treatment effectiveness and safety outcomes in elderly patients prescribed psychotropic agents.

Objectives: UK policy priority is to support people with dementia (PLwD) to live at home for longer. Initial clinical assessment involves evaluating and managing risk to enable PLwD to live safely and well at home. Risk assessment scales are needed to identify, manage and reduce risk within contemporary dementia practice. The “Islington Dementia Navigator Risk Assessment Tool” (IDNRAT) is used by specialist and non-specialist staff to stratify the level of risk for PLwD and inform a risk management plan and the frequency of follow-up. We assessed whether IDNRAT enables risk detection and whether the risk intervention derived from it is implemented and improves the safety of people living at home with dementia.

Methods: A mixed Methods study to evaluate IDNRAT’s validity, and the feasibility and acceptability of the resulting risk management plan. We investigated the use of the IDNRAT to: (i) detect risk (concurrent validity) and measure the reliability of the tool; (ii) contribute to risk reduction (primary outcome was numbers of decisions implemented); (iii) explore patients’ and carers’ experience of risk stratification.

Results: We found risk stratification scores (n = 119) derived from IDNRAT and compared with gold standard clinical risk assessments showed concordance between clinicians’ ratings. Joint Dementia navigator and researcher interviews (n = 19) showed consistency between the different assessor scores demonstrating IDNRAT has good reliability. Care-plan data showed most participants (n = 275) scored in the low-risk band of IDNRAT (78.9%) at baseline assessment and risk severity ratings (red/amber/green) reduced over the 6–12-month time period. PLwD (n = 19) and family carers (n = 17) had differing perceptions about risk and the PLwD’s susceptibility to risk. Overall, participants found the risk assessment acceptable, were able to identify risks and felt included in decision-making processes.

Conclusions: We found that the IDNRAT used by non-specialist practitioners (dementia navigators) does enable people with dementia to live safely at home in terms of risk- identification, implemented risk enablement decisions and acceptability. IDNRAT is a valid risk assessment tool, which offers a tailored approach to the management of risk, and over 80% of care-plan decisions were implemented. This is consistent with best practice and the tool has potential for wider use.

Background: Dementia is rapidly increasing in Asia.

Aim: There has been an Asian forum to ascertain country-specific patterns of management of dementia and to investigate country-specific characteristics.

Methods: In 2009, 11 dementia experts on Alzheimer’s from Korea, Japan, mainland China, Hong Kong China, Taiwan, Singapore, Philippines, Malaysia, Indonesia, Thailand, and India were invited to participate in the survey. The 33-item questionnaire were answered; awareness of dementia, characteristics of patients with memory problems, referral, diagnosis of MCI and dementia, diagnostic tools including the high-technology device, pharmacological treatment of MCI and dementia, current issues on AD, barriers and challenges in the management of dementia. Since then, 3 surveys have been completed in 2009, 2012, and 2024.

Results: New revised research diagnostic criteria for AD needing spinal tapping and brain imaging might not be adopted for clinical practice in memory clinics in Asia. Brain imaging studies like CT, MRI, SPECT, or PET are applied for more than 75% of patients as a usual part of the diagnostic workup in Korea, Japan, mainland China, Taiwan, Singapore, Indonesia, and Thailand, while 51 ∼ 75% in Philippines and 25 ∼ 50% in Hong Kong, Malaysia, and India. Proportion of patients who continue pharmacological treatment after the initial diagnosis of dementia varies country by country varies. Most countries endorsed all approved anti- dementia drugs, but some others approved a few of them (i.e., only donepezil present in Japan, galantamine absent in China, memantine absent in Indonesia, rivastigmine absent in Thailand. Cholinesterase inhibitors are prescribed in more than 90% of patients in 6 countries (i.e. Korea, Japan, Taiwan, Singapore, Philippines, Malaysia). In other 5 countries, medications like memantine, huperzine, ginkgo biloba, vitamin E, herb medicine or others are being more frequently prescribed than in above 6 countries.

Conclusions: Well-organized and planned governmental policies about dementia, in collaboration with dementia experts and their organizations, will effectively reduce burden of dementia in Asia, where an epidemic tide of dementia is approaching.

Introduction: Patients with mild to moderate dementia, progress to end stage dementia faster if they have more medical conditions (MCs) at their baseline evaluation, than those who have less MCs. Other recent studies have noted that the cognitive function of elderly people with subjective cognitive impairment (SCI) is five times more likely to further decline than those without SCI.

Objectives: Our aim was to determine; 1) whether the prevalence of medical comorbidities contribute to more rapid decline in cognitive functioning, and 2) whether the prevalence of medical conditions and the use of medications are different in patients with and without SCI.

Methods: Using rigorous inclusion and exclusion criteria, we enrolled 86 elderly people with normal cognition in a retrospective cross-sectional study.

Results: Our preliminary evaluation shows that medical conditions markedly influence the decline of cognitive functioning, even in the elderly with normal baseline cognitive function, and in the elderly with SCI have significantly more MCs and take more medications than those without SCI.

Conclusions: Further studies are needed to evaluate the change in the number of medications, frequency of cardiovascular diseases, history of surgeries and episodes or occurrences of depression between the evaluations.

Objectives: Antipsychotic use among patients with Alzheimer’s dementia can pose safety concerns, including accidents/injuries, cardiovascular events, extrapyramidal symptoms, and somnolence/sedation. In the US, brexpiprazole is approved for the treatment of agitation associated with dementia due to Alzheimer’s disease. This post hoc analysis aimed to evaluate the timing and duration of treatment-emergent adverse events (TEAEs) in three randomized clinical trials of brexpiprazole.

Methods: Data were included from three Phase 3, 12-week, randomized, double-blind, placebo-controlled trials of brexpiprazole in patients with agitation associated with Alzheimer’s dementia (ClinicalTrials.gov identifiers: NCT01862640, NCT01922258, NCT03548584). Data for all patients who received ≥1 dose of trial medication were pooled by randomized dose group: brexpiprazole 0.5 or 1 mg/day (fixed-dose), brexpiprazole 2 or 3 mg/day (fixed- dose) (FDA- approved recommended-to-maximum dose), brexpiprazole 0.5 – 2 mg/day (flexible-dose), and placebo. Time-to-event analyses were performed to first occurrence of any TEAE, any serious TEAE, discontinuation due to AE, and TEAEs of interest, separately, and presented using descriptive statistics and Kaplan–Meier Methodsology. The duration of all TEAEs in each category was also determined.

Results: The pooled sample comprised 1,043 patients. Median time to first TEAE was 24 days with brexpiprazole .5 or 1 mg/day (fixed-dose), 32 days with brexpiprazole 2 or 3 mg/day (fixed-dose), 28 days with brexpiprazole 0.5–2 mg/day (flexible-dose), and 28 days with placebo. Median duration of all TEAEs was 7 days, 6 days, 8 days, and 4 days (respectively). Median time to (and incidence of) discontinuation due to AEs was 45 days (8.9%) with brexpiprazole 0.5 or 1 mg/day, 46.5 days (4.9%) with brexpiprazole 2 or 3 mg/day, 30 days (6.8%) with brexpiprazole 0.5 –2 mg/day, and 30 days (3.4%) with placebo. The incidence of serious TEAEs and TEAEs of interest is presented in the Table.

Conclusions: In patients with agitation in Alzheimer’s dementia, time to first occurrence of any TEAE was similar between brexpiprazole 2 or 3 mg/day (FDA-approved recommended-to- maximum dose) and placebo, and time to discontinuation due to AEs was longer with brexpiprazole 2 or 3 mg/day than placebo. Overall, no unexpected safety concerns were revealed by this analysis.

Objectives: The aim of this study was to identify core and bridge symptoms between emergent neuropsychiatric symptoms and sleep disturbance in dementia-risk older adults with depressive symptoms in nursing homes using network analysis, and to further compare the structural differences in symptom networks between subthreshold depressive and depressive groups.

Methods: A total of 853 older adults in nursing homes participated in this study. We used the Mild Behavioral Impairment (MBI) and the Pittsburgh Sleep Quality Index (PSQI) to assess the severity of emergent neuropsychiatric symptoms and sleep disturbances, respectively, and the analyses also generated a network model of the MBI-PSQI in the sample and examined subthreshold depressive and depressive groups’ potential differences between network structure and connectivity.

Results: The core symptom in the global MBI-PSQI network of older adults with depressive symptoms in nursing homes was MBI8’’ (Lack of pleasure experience: 8.340), and the bridge symptom was PSQI7’’ (Daytime Dysfunction: 3.894). The edges connecting the nodes MBI2’’ (Lost curiosity in usual interests) and MBI3’’ (Decreased social initiative) in the global MBI-PSQI network has the strongest weight (0.798). Compared to the global network, for participants in the depression group, MBI8’’ (7.647) remains the most core symptom, and PSQI7’’ (4.028) serves as a critical bridge symptom between emergent neuropsychiatric symptoms and sleep disturbances. However, in the subthreshold depression group, the MBI-PSQI network structure exhibits distinct characteristics, with MBI2’’ (5.563) being revealed as the most significant symptom, closely followed by MBI8’’ (5.453). Furthermore, the bridge symptom connecting emergent neuropsychiatric symptoms to sleep disturbances shifts to PSQI4’’ (Sleep Efficiency: 1.386). Intriguingly, the strongest edge in both the global network and the subgroup network is MBI2-MBI3.

Conclusions: There is an association between emergent neuropsychiatric symptoms and sleep disturbance in dementia-risk older adults with depressive symptoms in nursing homes. In addition, heterogeneity in the network structure of subthreshold depression and depression, with shifts in core and bridge symptoms, providing directions for designing novel and targeted interventions.

Background: Mild behavioral impairment (MBI) in older people refers to a group of syndromes that are characterized primarily by clusters of neuropsychiatric symptoms without severe cognitive impairment, which is a high-risk population for dementia. Patients often experience a variety of symptoms and exhibit high heterogeneity in symptomatology across different individuals. Classifying the psychotic symptom characteristics of MBI patients aids in the implementation of precise interventions for the next steps.

Objectives: To explore the symptom characteristics of older people with MBI and to classify them based on their symptoms.

Methods: Using a multi-stage sampling Methods, the MBI-Checklist was employed to investigate symptom characteristics in 255 older people with MBI from 32 nursing homes in Fujian Province. Latent Class Analysis (LCA) was then employed to categorize these individuals based on their symptom profiles.

Results: The neuropsychiatric symptoms clusters in older people with MBI often present as a combination of lack of motivation and emotional dysregulation, lack of motivation and impulse control disorders, or emotional dysregulation and impulse control disorders; presentation of a single symptom cluster is relatively less common, accounting for 45.49%. Older people with MBI can be divided into 2 latent classes (P < 0.05) based on symptom characteristics. According to the conditional probability of each class, they were named the “high- level group’’ [211 (82.69%)] and the “low-level group’’[44 (17.31%)].

Discussion: As individuals with MBI are at high risk for developing dementia, early intervention can effectively delay or reduce the occurrence of dementia. Future interventions should be personalized based on the specific symptom characteristics of this population.

Summary: In his 1910 textbook, 8th Edition, Mental Illness in Old Age’’, E. Kraepelin stated, “The realm of late-life psychiatric disorders is perhaps the most unclear in the entirety of psychiatry.’’ More than a century later, it remains challenging to fully understand late-life psychiatric disorders, including late-life depression, late-life bipolar disorder, and late-life delusional states such as late paraphrenia. However, recent years have seen significant advancements. Neuropathological examinations of these late-life psychiatric disorders are gradually uncovering the underlying diseases. In addition, progress in neurofunctional imaging studies using positron emission tomography (PET) is shedding light on their neurological foundations. Traditionally, mood disorders and delusional conditions in the elderly were considered distinct from dementia. Yet, over time, more cases are being observed to progress into some form of dementia or neurodegenerative diseases. These cases are suspected to have diverse neuropathological entities based on the type of abnormal proteins accumulating in the brain, such as amyloidopathy, synucleinopathy, or tauopathy. Among these, we have specifically revealed that tauopathy is a background factor in some cases of late-life mood disorders and late-life delusional states, using Florzolotau tau PET imaging. We have also found that psychiatric symptoms like delusions are related to the degree of accumulation of tau proteins. The involvement of tau pathology in symptom formation in late-life psychosis suggests that disease-modifying drugs targeting tau, which may emerge in the near future, could be effective in treating these individuals.

Objectives: Highlight the presentation of behavioral symptoms in addition to the classic clinical trial in idiopathic normal pressure hydrocephalus in the elderly. Identify apathy as the most prevalent behavioral symptom in normal pressure hydrocephalus (NPH) in the elderly.

Methods: A bibliographic review of apathy as a behavioral symptom of NPH is carried out. Likewise, in addition to highlighting apathy as a possible diagnostic marker, the evidence of it as a prognostic marker of therapeutic response is discussed. For this, a review of publications in English and Spanish from the last 10 years was carried out in databases including Cochrane Library, EMBASE, MEDLINE/PubMed, SCOPUS. The MESH terms apathy, Hakims-Adams, idiopathic normal pressure hydrocephalus, chronic hydrocephalus, neuropsychiatric symptoms were used for the search.

Results: Sixteen articles were selected that verified the heterogeneity of the diagnostic criteria for apathy for its detection in patients with NPH. Likewise, it is identified that apathy is the most prevalent behavioral alteration with a prevalence of 60% of patients in this condition. Regarding its predictive value as a prognostic marker for shunt surgical treatment, the evidence is not conclusive either to confirm or to rule out the usefulness of apathy. Conclusions: Apathy should be considered as another diagnostic key in NPH. Thus, the classic description of this condition as a motor-cognitive-urinary syndrome must be reconceptualized as a motor-cognitive-behavioral- urinary syndrome.

Objectives: Health professionals in our setting rarely ask adequately about sleep disorders beyond insomnia in depressive patients. This presentation aims to review the possible clinical situations between geriatric depression (GD) and sleep apnea and hypopnea syndrome (SAHS) and highlight the clinical impact of their adequate detection and treatment.

Methods: Presentation of a sample of 25 older adult patients from the Geriatric Neuropsychiatry Clinic and the Psychogeriatric Section of the Department of Psychiatry of the CEMIC (Buenos Aires, Argentina) with diagnoses of GD and SAHS.

Results: Presentation of different groups of patients with possible relationships in which these two entities interact: a) GD as a risk factor for developing SAHS; b) SAHS as a risk factor for developing GD; c) GD and SAHS as comorbidities; d) GD and SAHS as risk factors for morbidity and mortality for multiple diseases; e) SAHS as a cause of pseudo-resistance to antidepressant treatment in GD; e) GD as a cause of pseudo-resistance to SAHS treatment; f) the treatment of GD as a cause of pseudo-resistance to SAHS treatment; g) the treatment of SAHS as “a cause of” and/or “aggravate” of GD.

Conclusions: Mental health professionals must actively investigate in their older patients the possible relationships between GD and SAHS in order to ensure the diagnosis and appropriate treatments adapted to such clinical situations.

Objectives: To identify the characteristics and principals’ diagnosis of the older patients of a mental service in order to design the basis of an intervention plan.

Methods: Retrospective longitudinal observational study based on a secondary database provided by Mentalitat. Results: On a year 30% of the attention were over 60 years old, 70% of them was women with anxiety disorder, mixed anxiety-depression disorder, and mayor neurocognitive disorder. Almost half of the dementias had not reported etiology despite the repeat attentions.

Conclusions: In order to improve the mental state and reduce hospitalization interventions should be focused on women with anxiety or/and depression and brain health to influence the incidence of neurocognitive impairment and the quality of life; emphasizing dementia training for mental health care.

Objectives: Older people with care needs are often supported by their older care-partners (50+). Over time, the increased demand in care needs can result in the care partner placing their own health needs aside. This study was aimed at establishing and piloting a novel co-designed Carer Health and Wellbeing Service (CHWS) that offers multidisciplinary (social work, psychology, occupational therapy, and physiotherapy) one-to-one support to care partners.

Methods: We conducted a pre-post 6-month study design including qualitative and quantitative Methods. Consenting individuals attending the CHWS completed five measures pre- and post- their interaction with the CHWS: Carer Support Needs Assessment Tool (CSNAT); Preparedness for Caregiving Scale (PCS); Family Appraisal of Caregiving Questionnaire (FACQ); EuroQoL Five Dimension Five Level Scale (EQ-5D-5L); and Health Economics Survey.

Results: Service operation commenced 1 day/week in March 2024 with 16 participants to date. Preliminary pre- service use indicates care partners feel underprepared for the carer role (particularly emotionally and psychologically), experience high levels of guilt when addressing their own care needs and are unsure about how to advocate or navigate the existing support system. Care partners have been coached to identify, prioritize, and address their current health and wellbeing needs. Additional findings regarding the implementation of the CHWS will be reported in this presentation.

Conclusions: The preliminary sample presents several emotional and psychological needs that need addressing. These will inform the type of support services to be provided as part of the CHWS, which will also be presented at the conference.