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Published online by Cambridge University Press: 21 June 2016
Although we think of malaria as a disease of the tropics, it is sobering to recall that in the beginning of this century, more than two-thirds of the earth's population lived in areas where malaria was endemic. The United States and Europe were both rife with malaria, and the disease changed the course of world history many times. Indeed, in Western Africa during 1942, the incidence of malaria was as high as 1,071 cases per 1,000 soldiers per year.