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Analysis of distributions of single-locus heterozygosity as a test of neutral theory

Published online by Cambridge University Press:  14 April 2009

M. Woodwark ,
D. O. F. Skibinski  and
R. D. Ward
M. Woodwark
Affiliation:
School of Biological Sciences, University College of Swansea, Singleton Park, Swansea SA2 8PP, U.K.
D. O. F. Skibinski*
Affiliation:
School of Biological Sciences, University College of Swansea, Singleton Park, Swansea SA2 8PP, U.K.
R. D. Ward
Affiliation:
C.S.I.R.O., Division of Fisheries, G.P.O. Box 1538, Hobart, Tasmania 7001, Australia
*
* Corresponding author.
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Summary

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Three tests of neutral theory were carried out using a large dataset of vertebrate allozyme studies. The first test considered the relationship between the mean and variance of single locus heterozygosity across a sample of enzymes and non-enzymatic proteins. The second test compared the distributions of heterozygosity between paired proteins in balanced datasets in which each protein is scored for the same sample of species. The third test compared the observed distribution of single locus heterozygosity with theoretical distributions predicted by neutral theory. The results show an excellent quantitative fit with the predictions of neutral theory, though some small deviations from neutrality were observed which are consistent with the action of natural selection.

Type
Research Article
Information
Genetics Research , Volume 62 , Issue 3 , December 1993 , pp. 223 - 230
Copyright
Copyright © Cambridge University Press 1993

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