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Valproato (Depakine Crono) en el tratamiento agudo de pacientes ambulatorios con trastorno de ansiedad generalizada sin otras enfermedades psiquiátricas: Estudio aleatorizado, doble ciego y controlado por placebo

Published online by Cambridge University Press:  01 May 2008

Nadir A. Aliyev  and
Zafar N. Aliyev
Nadir A. Aliyev
Affiliation:
Clínica Mental Ambulatoria, Bakú, C/U. Chagibekov, 46/50, F.I., Apartado de Correos de Bakú AZ00l0, República de Azerbayán
Zafar N. Aliyev
Affiliation:
Clínica Mental Ambulatoria, Bakú, C/U. Chagibekov, 46/50, F.I., Apartado de Correos de Bakú AZ00l0, República de Azerbayán
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Resumen

Objetivo.

Los trastornos de ansiedad son muy frecuentes en la población de múltiples países europeos. Sin embargo, hasta ahora no se ha estudiado el efecto de valproato (Depakine Crono) sobre el trastorno de ansiedad generalizada (TAG) en un diseño doble ciego controlado por placebo.

Método.

Se eliminaron todas las medicaciones de 80 pacientes (todos hombres). Cada paciente fue aleatorizado para recibir Depakine Crono (40 pacientes) durante 6 semanas o un placebo similar (40 pacientes) de forma doble ciega. Los participantes candidatos, además de cumplir los criterios de TAG del DSM-1V y de tener una puntuación mínima de 25 o más en la Escala de Ansiedad de Hamilton, debían tener entre 18 y 65 años. La respuesta se definió como una reducción del 50% de la puntuación en la escala de ansiedad de Hamilton. La respuesta y los efectos secundarios con Depakine Crono y placebo se compararon por análisis de varianza (ANOVA) y tests de χ 2. Seis pacientes no realizaron ni siquiera una evaluación posterior, por lo que se incluyeron finalmente 74 pacientes (36 tratados con Depakine Crono y 38 con placebo) en el grupo de estudio de variables.

Resultados.

Veintiséis de los 36 participantes tratados con Depakine Crono respondieron antes de 6 semanas, frente a seis de los 38 tratados con placebo (p < 0,001). Los efectos secundarios más comunes y problemáticos en el grupo tratado con Depakine Crono fueron el vértigo y las náuseas.

Conclusiones.

Los autores creen que éste es el primer estudio doble ciego, aleatorizado y controlado por placebo para probar la eficacia de Depakine Crono en el tratamiento de los trastornos de ansiedad. Esto debe ser reproducido con un grupo de estudio más numeroso.

Keywords

Depakine CronoTrastorno de ansiedad generalizadaTratamiento
Type
Artículo original
Information
European Psychiatry (Ed. Española) , Volume 15 , Issue 4 , May 2008 , pp. 181 - 186
Copyright
Copyright © European Psychiatric Association 2008

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References

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