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Alteraciones de las concentraciones de factor neurotrófico derivado de la línea de células gliales (GDNF) en el cerebro de pacientes con trastorno depresivo: Estudio comparativo post mortem.
Published online by Cambridge University Press: 12 May 2020
Resumen
Introducción
Hay cada vez más evidencias que indican que el factor neurotrófico derivado de la línea de células gliales (GDNF) está implicado en la etiopatología de los trastornos del ánimo. El GDNF es un factor neurotrófico de la familia de los factores transformadores del crecimiento que desempeña algún papel en el desarrollo de las células y en la función del sistema límbico. Éste es el primer estudio que ha examinado la concentración de GDNF en diferentes regiones cerebrales de pacientes con trastorno depresivo (TD).
Material y métodos
Usamos una técnica sandwich-ELISA para determinar la concentración de GDNF y el ensayo de Lowry para calcular las concentraciones de proteínas totales en tejido cerebral p o st mortem en 7 pacientes con trastorno depresivo recurrente y en 14 individuos sin ningún diagnóstico neurológico o psiquiátrico. Incluimos regiones corticales y áreas límbicas (hipocampo, corteza entorrinal), ganglios basales (putamen, núcleo caudal), tálamo y circunvolución cingulada.
Resultados
Encontramos un aumento significativo de la concentración de GDNF en la corteza parietal de los pacientes con TD comparados con el grupo de control. En otras regiones, la tendencia al aumento de la concentración de GDNF no indicó ninguna diferencia estadísticamente significativa.
Discusión
Este estudio de prueba de concepto confirma resulados anteriores que indicaban que había una alteración del GDNF en pacientes con trastorno depresivo. Sin embargo, es la primera vez que se ha encontrado un aumento significativo de GDNF en un área cortical cerebral en pacientes con TD.
- Type
- Original
- Information
- Copyright
- Copyright © European Psychiatric Association 2008
References
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