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Funcionamiento psicosocial en pacientes con depresión resistente al tratamiento

Published online by Cambridge University Press:  12 May 2020

Timothy Petersen ,
George I. Papakostas ,
Yasmin Mahal ,
Wendy M. Guyker ,
Erin C. Beaumont ,
Jonathan E. Alpert ,
Maurizio Fava  and
Andrew A. Nierenberg
Timothy Petersen
Affiliation:
Departamento de Psiquiatría, Programa de Depresión Clínica e Investigación, Hospital General de Massachusetts, 15 Parkman Street, WAC 812Boston, MA02114, EEUU
George I. Papakostas
Affiliation:
Departamento de Psiquiatría, Programa de Depresión Clínica e Investigación, Hospital General de Massachusetts, 15 Parkman Street, WAC 812Boston, MA02114, EEUU
Yasmin Mahal
Affiliation:
Departamento de Psiquiatría, Programa de Depresión Clínica e Investigación, Hospital General de Massachusetts, 15 Parkman Street, WAC 812Boston, MA02114, EEUU
Wendy M. Guyker
Affiliation:
Departamento de Psiquiatría, Programa de Depresión Clínica e Investigación, Hospital General de Massachusetts, 15 Parkman Street, WAC 812Boston, MA02114, EEUU
Erin C. Beaumont
Affiliation:
Departamento de Psiquiatría, Programa de Depresión Clínica e Investigación, Hospital General de Massachusetts, 15 Parkman Street, WAC 812Boston, MA02114, EEUU
Jonathan E. Alpert
Affiliation:
Departamento de Psiquiatría, Programa de Depresión Clínica e Investigación, Hospital General de Massachusetts, 15 Parkman Street, WAC 812Boston, MA02114, EEUU
Maurizio Fava
Affiliation:
Departamento de Psiquiatría, Programa de Depresión Clínica e Investigación, Hospital General de Massachusetts, 15 Parkman Street, WAC 812Boston, MA02114, EEUU
Andrew A. Nierenberg
Affiliation:
Departamento de Psiquiatría, Programa de Depresión Clínica e Investigación, Hospital General de Massachusetts, 15 Parkman Street, WAC 812Boston, MA02114, EEUU
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Resumen

Antecedentes.

La depresión es un trastorno que causa discapacidad, con un efecto adverso profundo en todas las áreas del funcionamiento social. Esto es particularmente cierto para las personas con depresión resistente al tratamiento (DRT). Sin embargo, hasta la fecha, no se han realizado evaluaciones sistemáticas del funcionamiento psicosocial para los pacientes con DRT.

Métodos.

En el presente estudio, utilizamos la escala Evaluación de Seguimiento del Intervalo Longitudinal (LIFE) para medir el funcionamiento psicosocial en 92 pacientes con DRT. Estos pacientes cumplían los criterios formales para DRT y eran parte de un ensayo clínico que examinaba la eficacia del aumento con litio de la nortriptilina.

Resultados.

Los profesionales clínicos consideraron que esta muestra experimentaba deterioro de leve a moderado en las actividades relacionadas con el trabajo, relaciones interpersonales de bu, deterioro leve de la capacidad para disfrutar de la actividad sexual. Los pacientes y los profesionales clínicos consideraron la adaptación social global como deficiente.

Conclusions.

Los pacientes con DRT defmida formalmente experimentan un deterioro significativo en el funcionamiento psicosocial. En esta muestra, tanto los profesionales clínicos como los pacientes tenían una tendencia a asignar calificaciones globales de deterioro más graves comparado con las calificaciones para las áreas funcionales específicas.

Keywords

Depresión resistente al tratamientoFuncionamiento psicosocial
Type
Artículo original
Information
European Psychiatry (Ed. Española) , Volume 11 , Issue 8 , November 2004 , pp. 508 - 513
Copyright
Copyright © European Psychiatric Association 2000

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References

Bibliografía

Akiskal, HS.Factors associated with incomplete recovery in primary depressive illness. J Clin Psychiatry 1982;43:266–271.Google ScholarPubMed
Beck, AT, Kovacs, M, Weissman, A.Assessment of suicidal intention: the Scale for Suicide Ideation. J Consult Clin Psychol 1979;47(2):343–52.CrossRefGoogle ScholarPubMed
Broadhead, WE, Blazer, DG, George, LK, Tse, CK.Depression, disability days, and days lost from work in a prospective epidemiological survey. JAMA 1990;264:25248.CrossRefGoogle Scholar
Covi, L, Lipman, RS, Alarcon, R, Smith, VK.Drug and psychotherapy interactions in depression. Am J Psychiatry 1976;133:502–508.Google ScholarPubMed
Downing, RW, Rickels, K.Predictors of amitriptyline response in outpatient depressives. J Nerv Ment Dis 1972;154:248–263.CrossRefGoogle ScholarPubMed
Fava, M, Kaji, J, Davidson, K.Pharmacologic strategies for treatment resistant major depression. In: Pollack, MH, Otto, MW, Rosenbaum, JF, editors. Challenges in clinical practice: pharmacologic and psychosocial strategies. New York: The Guilford Press; 1996.Google Scholar
Fava, M, Davidson, KG.Definition and epidemiology of treatment-resistant depression. Psychiatr Clin North Am 1996;19(2):179–200.CrossRefGoogle ScholarPubMed
George, LK, Blazer, DG, Hughes, DC, Fowler, N.Social support and the outcome of major depression. Br J Psychiatry 1989;154:478–485.CrossRefGoogle ScholarPubMed
Greden, JE.The burden of disease for treatment-resistant depression. J Clin Psychiatry 2001;62(Suppl 16):26–31.Google ScholarPubMed
Greenberg, PE, Stiglin, LE, Finkelstein, SN, Bemdt, ER.The economic burden of depression in 1990. J Clin Psychiatry 1993;54:405–418.Google ScholarPubMed
Hamilton, M.A rating scale of depression. J Neurol Neurosurg Psychiatry 1960;23:56–62.CrossRefGoogle Scholar
Hirschfeld, RM, Russell, JM, Delgado, PL, Fawcett, J, Friedman, RA, Harrison, WM, et al.Predictors of response to acute treatment of chronic and double depression with sertraline or imipramine. J Clin Psychiatry 1998;59(12): 669–75.CrossRefGoogle ScholarPubMed
Kaplan, RM, Anderson, JR.The general health policy model: an integrated approach. 2nd ed. In: Spilker, B, editor. Quality of life and pharmacoeconomics in clinical triáis. Philadelphia, PA: Lippincott Raven; 1996. p. 309–21.Google Scholar
Keitner, Gl, Ryan, CE, Miller, IW, Nommand, WH.Recovery and major - depression: factors associated with twelve-month outcome. Am J Psychiatry 1992;149:93–99.Google ScholarPubMed
Keller, MB.The longitudinal interval follow-up evaluation: a comprehensive method for assessing outcome in prospective longitudinal studies. Arch Gen Psychiatry 1987;44:540–548.CrossRefGoogle ScholarPubMed
Keller, MB, Klemman, GL, Lavori, PW.Long term outcome of episodes of major depression. JAMA 1984;252:788–792.CrossRefGoogle ScholarPubMed
Keller, MB, Lavori, PW, McDonald-Scott, P, Endicott, J, Andreasen, N, Van Eerdewegh, MM.The reliability of retrospective treatment reports. Psychiatry Res 1983;9:81–88.CrossRefGoogle ScholarPubMed
Keller, MB, Lavori, PW, Mueller, TI, Endicott, J, Coryell, W, Hirschfeld, RM, et al.Time to recovery, chronicity, and levels of psycho-pathology in major depression. A 5 year prospective follow-up of 431 subjects. Arch Gen Psychiatry 1992;49(16):809–16.CrossRefGoogle Scholar
Kessler, RC, Barber, C, Bimbaum, HC, Frank, RG, Greenberg, PE, Rose, RM, et al.Depression in the workplace: effects on short-term disability. Health Aff (Millwood) 1999;18:163–171.CrossRefGoogle ScholarPubMed
Koivumaa-Honkanen, H, Honkanen, R, Antikainen, R, Hintikka, J, Laukkanen, E, Honkalampi, K, et al.Self-reported life satisfaction and recovery from depression in a 1-year prospective study. Acta Psychiatr Scand 2001; 103(l):38–44.CrossRefGoogle Scholar
Komstein, SG, Schneider, RK.Clinical features of treatment-resistant depression. J Clin Psychiatry 2001;62(Suppl 16): 18–62.Google Scholar
Mischoulon, D.An approach to the patient seeking psychiatric disability benefits. J Am Acad Psychiatry Law 1999;23(3): 128–36.CrossRefGoogle Scholar
Moos, RH.Depressed outpatients’ life contexts, amount of treatment, and treatment outcome. J Nerv Ment Dis 1990;178:105–112.CrossRefGoogle ScholarPubMed
Murray, CJL, López, AD.Alternative projections of mortality and disability by cause. 1990-2020: global burden of disease study. Lancet 1997;349:1498–504.CrossRefGoogle ScholarPubMed
Murray, CJL, López, AD.Global mortality, disability, and the contribution of risk factors: global burden of disease study. Lancet 1997b; 349:1436–42.CrossRefGoogle Scholar
Nierenberg, AA, Keck, PE, Samson, J, Rothschild, AJ, Schatzberg AE Methodologic considerations for the study of treatment-resistant depression. In: Amsterdam, JD, editor. Refractory depression. New York: Raven Press; 1991. p. 217 44.Google Scholar
Ormel, J, Von Korff, M, Oldehinkel, AJ, Simón, G, Tiemens, BG, Ustun, TB.Onset of disability in depressed and non-depressed primary care patients. Psych Med 1999;29:847–853.CrossRefGoogle ScholarPubMed
Parikh, SV, Wasylenki, D, Goering, P, Wong, J.Mood disorders: raral/urban differences in prevalence, health care utilization, and disability in Ontano. J Affect Dis 1996;38:57–65.CrossRefGoogle Scholar
Parikh, SV, Lam, RW, CANMAT Depression Work Group. Clinical guidelines for the treatment of depressive disorders. I. Definitions, prevalence and health burden. Can J Psychiatry 2001 ;46(1): 13S–20S.Google ScholarPubMed
Price, LH, Chamey, DS, Heninger, GR.Variability of response to lithium augmentation in refractory depression. Am J Psychiatry 1986; 143:1387–92.Google ScholarPubMed
Pyne, JM, Bullock, D, Kaplan, RM, Smith, TL, Gillin, C, Golshan, S, et al.Health-related quality of life measures enhances acute treatment response prediction in depressed inpatients. J Clin Psychiatry 2001;62:261–268.CrossRefGoogle Scholar
Roundaville, BJ, Weissman, MM, Prusoff, BA, Herceg-Baron, RL.Marital disputes and treatment outcome in depressed women. Comp Psychiatry 1979;20:483–490.CrossRefGoogle Scholar
Rost, K, Zhang, M, Fortney, J, Smith, J, Smith, G.Expenditures for the treatment of major depression. Am J Psychiatry 1998; 155(7):883–8.CrossRefGoogle ScholarPubMed
Riise, T, Lund, A.Prognostic factors in major depression: a long-term follow-up study of 323 patients. J Affect Dis 2001;65(3):297–306.CrossRefGoogle ScholarPubMed
Rodríguez, E, Frongillo, EA, Chandra, P.Do social programmes contribute to mental well-being? The long-temm impact of unemployment on depression in the United States. Int J Epidemiol 2001; 30:163–70.CrossRefGoogle ScholarPubMed
Scott, J, Barker, WA, Eccleston, D.The Newcastle chronic depression study. Patient characteristics and factors associated with chronicity. Br J Psychiatry 1988;152:28–33.CrossRefGoogle ScholarPubMed
Simon, GE, VonKorff, M, Barlow, W.Health care costs of primary care patients with recognized depression. Arch Gen Psychiatry 1995;52:850–856.CrossRefGoogle ScholarPubMed
Skodol, AE, Gunderson, JG, McGlashan, TH, Dyck, IR, Stout, RL, Bender, DSet al.Functional impairment in patients with schizotypal, borderline, avoidant, or obsessive-compulsive personality disorder. Am J Psychiatry 2002;159(2):276-83.CrossRefGoogle ScholarPubMed
Spitzer, RL, Williams, JB, Gibbon, M, First MB. Structured Clinical Interview for DSM-III-R-Patient edition (SCID-P). New York: New York State Psychiatric Institute, Biometrics Research Department; 1989.Google Scholar
Vallejo, J, Gasto, C, Catalan, R, Bulbena, A, Menchon, JM.Predictors of antidepressant treatment outcome in melancholia: psychosocial, clinical and biological indicators. J Affect Dis 1991;21:151–162.CrossRefGoogle ScholarPubMed
Weissman, MM.Social functioning and the treatment of depression. J Clin Psychiatry 2000;61(Suppl l):33–8.Google ScholarPubMed
Wells, K, Stewart, A, Hays, RD, Bumman, A, Rogers, W, Daniels, M, et al.Results from the Medical Outcomes Study. The function and wellbeing of depressed patients. JAMA 1989;262(7):914–9.CrossRefGoogle Scholar
Wells, KB, Strom, R, Sherboume, CD, Meredith, LS.Caring for depression: a RAND study. Cambridge: Harvard University Press; 1996.Google Scholar