In a previous paper1 one of us has summarized what is known with regard to canine piroplasmosis, and presented the results of infection experiments carried on in Cambridge with infected ticks (adult Haemaphysalis leachi Andouin) imported from South Africa. In the present paper we propose to describe and figure the parasite as observed in stained preparations, and to state what is known regarding its biology. The supply of infected ticks having unfortunately been exhausted and our last attempt at the transmission of the disease by infected blood inoculation having failed, we are obliged, for the present, to postpone a detailed description of the living parasite.

In the preceding paper the morphology of the parasites found in the peripheral circulation and in the organs of eleven dogs experimentally infected with Canine Piroplasmosis has been described. In the following pages will be considered the morbid lesions found in hese dogs, and the proportions of the variously infected red corpuscles to one another, both in the organs and in the blood.

Having examined the blood in a number of the dogs suffering from Piroplasmosis, referred to in the previous papers, I have selected three charts to show the changes I found to take place in the blood during the progress of the disease. For the enumeration of the corpuscles the Thoma-Zeiss haemacytometer was used, and for estimating the haemoglobin, Haldane's modification of Gower's haemoglobinometer.

So much has been written concerning Piroplasmosis as it occurs in different animals in various parts of the world that one may be pardoned for directing attention to the fact that the disease exists at home and is constantly coming before the notice of the veterinarian at this time of the year.

No investigations seem to have been made in recent years as to the prevalence of intestinal worms among the general population in this country. The present results are derived from the microscopical examination of the stools of 500 in-patients of Guy's Hospital. The cases were taken consecutively by beds all through the hospital, without any selection, over a period of ten months, and comprise surgical and medical as well as gynaecological and other special patients. Nearly all were inhabitants of London.

IN view of a previous failure1 to produce a skin infection with Ankylostoma, it seems worth while to put on record the present successful case. Dr J. B. Leathes very kindly offered himself as the subject of experiment. It is important to note that he has never, either before or during the course of the experiment, had anything to do with any Ankylosotoma material except that deliberately applied to his person for the purpose of this experiment, nor has he been to any infected place or even worked in the part of the Institute where the cultures of Ankylosotoma larvae have been kept. On March 21st a small quantity of water containing encapsuled larvae of A. duodenale, hatched artificially from infected faeces from Cornwall, and 13 days old, was applied to the forearm. After five minutes the arm was bandaged up and left for two hours, at the end of which time the wrappings were removed and the arm throughly cleansed. The purpose of the experiment and the precautions necessary were fully appreciated by the subject, and there is no doubt that there was not the slightest possibility of a mouth infection.

It is generally recognised that, in certain diseases, recovery mainly depends upon the prompt and efficient reaction of the tissues forming antibodies, such as bacteriolysins, antitoxins, and the like, and it is possible that these peculiar. biological responses may be influenced by the administration of drugs.

In the last number of the Journal of Hygiene we described an improved method of calculating birth-rates, by means of which exact correction can be made, in comparing the birth-rates of two communities or of the same community at different periods, for variations in the proportion of married women at childbearing ages, and for the different fertility-rates at different ages of childbearing life. The value of this method consists in the fact that by its means true differences in childbearing can be discovered, the differences due to variations of age or marital condition being eliminated.

Plague was introduced into Queensland from Sydney in 1900, and every subsequent year has been marked by an outbreak in Brisbane. In both towns the authorities are unsparing in their efforts to eradicate the factors contributing to its maintenance, but in both places the infection of the rats and their haunts is so extensive that the disease may now be looked upon as endemic in the two cities. The probabilities are, however, that the pest will be harder to eradicate in Sydney, where the buildings are substantially built, and not as in Brisbane light structures of wood which more easily lend themselves to treatment and are comparatively temporary in their character.

The following experiments were begun with the object of ascertaining the distribution in nature of certain lactose-fermenting organisms which are by some grouped under the name Bacillus coli, but by others are regarded as belonging to a different class of organisms; a difference of opinion which is most probably the principal factor in causing the value of B. coli as an index of pollution to be such a vexed question among bacteriologists. The investigation, however, resolved itself into a search for the B. lactis aerogenes principally, and secondarily for the other lactose fermenters. Incidentally certain other points are referred to which it was thought might prove of interest though not actually pertaining to the subject of the paper.

The following investigation was undertaken at the request of the War Office Committee on Antityphoid Inoculation, to ascertain the nature and degree of the changes that occur in the blood after inoculation, and to determine the extent to which these changes are influenced by differences in the dosage of the vaccine.