Hostname: page-component-586b7cd67f-t8hqh Total loading time: 0 Render date: 2024-11-24T21:45:10.230Z Has data issue: false hasContentIssue false
  • English
  • Français

A randomized, controlled, double-blind, cross-over, clinical trial of Q fever vaccine in selected Queensland abattoirs

Published online by Cambridge University Press:  15 May 2009

R. A. Shapiro ,
V. Siskind ,
F. D. Schofield ,
N. Stallman ,
D. A. Worswick  and
B. P. Marmion
R. A. Shapiro*
Affiliation:
Department of Social and Preventive Medicine, University of Queensland
V. Siskind
Affiliation:
Department of Social and Preventive Medicine, University of Queensland
F. D. Schofield
Affiliation:
Department of Social and Preventive Medicine, University of Queensland
N. Stallman
Affiliation:
State Microbiological Laboratory, Queensland Department of Health
D. A. Worswick
Affiliation:
Division of Medical Virology, Institute of Medical and Veterinary Science, Adelaide, South Australia
B. P. Marmion
Affiliation:
Division of Medical Virology, Institute of Medical and Veterinary Science, Adelaide, South Australia
*
Dr R. A. Shapiro, Department of Social and Preventive Medicine, Medical School, University of Queensland, Herston Road, Herston, Qld, 4006.
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

A limited, randomized, blind, placebo-controlled trial of Q fever and influenza vaccines has been conducted in three Queensland abattoirs on a sequential analysis design. Ninety-eight subjects were given Q fever vaccine and 102 influenza vaccine. Q fever cases were observed in unvaccinated workers in all three abattoirs during the period of observation.

A total of seven Q fever cases in one group, one more than the number required to achieve statistical significance between the two vaccine groups, was reached after 15 months with the cases coming from two of the abattoirs. These Q fever cases were in the group which had been given influenza vaccine and none in that given Q fever vaccine.

Symptomless seroconversion rates of 24% were found in the remaining influenza virus vaccinees, and those without immunity were given Q fever vaccine.

Type
Research Article
Information
Epidemiology & Infection , Volume 104 , Issue 2 , April 1990 , pp. 267 - 273
Copyright
Copyright © Cambridge University Press 1990

References

REFERENCES

Marmion, BP, Ormsbee, RA, Kyrkou, M, et al. Vaccine prophylaxis of abattoir-associated Q fever; eight years' experience in Australian abattoirs. Epidemiol Infect 1990; 104: 275–87.CrossRefGoogle ScholarPubMed
Izzo, A, Marmion, BP, Worswick, DA. Markers of cell-mediated immunity after vaccination with an inactivated whole cell Q fever vaccine. J Inf Dis 1988; 157: 781–9.CrossRefGoogle ScholarPubMed
Derrick, EH.Q fever, a new fever entity: clinical features, diagnosis and laboratory investigation. Med J Aust 1937; 2: 281–99.CrossRefGoogle Scholar
Marmion, BP, Ormsbee, RA, Kyrkou, M, et al. Vaccine prophylaxis of abattoir-associated Q fever. Lancet 1984; ii: 1411–4.CrossRefGoogle Scholar
Benenson, AS. Q fever vaccine: efficacy and present status. In: Smadel, JE, ed. Symposium on Q fever. Walter Reed Army Institute of Medical Science Publication No. 6, U.S. Government Printing Office, Washington D.C., 1959: 47–60.Google Scholar
Fiset, P. Vaccination against Q fever. In: Proceedings of First International Congress on vaccines against viral and rickettsial diseases of man, PAHO Science Publication 1967; 147: 528.Google Scholar
Armitage, P, Berry, G. Statistical methods in medical research. Blackwell Scientific Publications, 1987.Google Scholar
Worswick, D, Marmion, BP. Antibody responses in acute and chronic Q fever and in subjects vaccinated against Q fever. J Med Microbiol 1985; 19: 281–96.CrossRefGoogle ScholarPubMed