Hostname: page-component-cd9895bd7-lnqnp Total loading time: 0 Render date: 2024-12-22T15:28:59.088Z Has data issue: false hasContentIssue false
  • English
  • Français

Antibody response and persistence in volunteers following immunization with varying dosages of a trivalent surface antigen influenza virus vaccine

Published online by Cambridge University Press:  19 October 2009

R. Jennings ,
T. L. Smith ,
A. R. Mellersh ,
A. Clark ,
R. C. Spencer  and
C. W. Potter
R. Jennings
Affiliation:
Departments of Virology and Medical Microbiology, Medical School, University of Sheffield, Sheffield S10 2RX
T. L. Smith
Affiliation:
Departments of Virology and Medical Microbiology, Medical School, University of Sheffield, Sheffield S10 2RX
A. R. Mellersh
Affiliation:
Departments of Virology and Medical Microbiology, Medical School, University of Sheffield, Sheffield S10 2RX
A. Clark
Affiliation:
Departments of Virology and Medical Microbiology, Medical School, University of Sheffield, Sheffield S10 2RX
R. C. Spencer
Affiliation:
Departments of Virology and Medical Microbiology, Medical School, University of Sheffield, Sheffield S10 2RX
C. W. Potter
Affiliation:
Departments of Virology and Medical Microbiology, Medical School, University of Sheffield, Sheffield S10 2RX
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The serum antibody responses and 50% protective levels (PL50) of antibody were determined, using the SRH test, at one and twelve months post-vaccination in a group of student volunteers immunized with one of three dosages of a trivalent surface-antigen influenza virus vaccine, or with placebo.

It was found that, for the H3, H1 and B haemagglutinin components present in the vaccine, a dose of 6 μg HA elicited high serum antibody responses at one month post-immunization. High mean antibody levels and a high incidence of volunteers with PL50 values of antibody against each of the HA components of the vaccine remained in the volunteer group twelve months later. The results are discussed in relation to the vaccine dosage used and the nature of the population immunized.

Type
Research Article
Information
Journal of Hygiene , Volume 94 , Issue 1 , February 1985 , pp. 87 - 95
Copyright
Copyright © Cambridge University Press 1985

References

REFERENCES

Al-Khayatt, R., Jennings, R. & Potter, C. W. (1984). Interpretation of responses and protective levels of antibody ngainst attenuated influenza A viruses using single radial haemolysis. Journal of Hygiene. 93, 301–312.CrossRefGoogle ScholarPubMed
Bhady, M. I. & Furminqer, I. G. S. (1976). A surface antigen influenza vaccine. I. Purification of haemagglutinin and neuraminidase proteins. Journal of Hygiene 77, 101–180.Google Scholar
Cate, T. R., Couch, R. B., Parker, D. & Baxter, B. (1983). Reactogenicity, immunogenicity and antibody persistence in adults given inactivated influenza virus vaccines – 1978. Reviews of Infectious Disease 5, 737–747.CrossRefGoogle ScholarPubMed
Clark, A., Potter, C. W., Jennings, R., Nicholl, J. P., Lanorick, F., Schild, G. C, Wood, J. M. & Tyrrell, D. A. J. (1983). A comparison of livo and inactivated influenza A (HINl) virus vaccines. 2. Long-term immunity. Journal of Hygiene 90, 301–370.Google Scholar
Goodeve, A. C, Jennings, R. & Potter, C. W. (1983). The use of the single radial haemolysis test for assessing antibody response and protective antibody levels in an influenza H vaccine study. Journal of Biological Standardisation 11, 289–290.CrossRefGoogle Scholar
Goodeve, A. C, Potter, C. W., Clark, A., Jbnnings, R., Schild, G. C. & Yetts, R. (1983). A graded-dose study of inactivated, surface antigen influenza B vaccine in volunteers: reactogenicity, antibody response and protection to challenge virus infection. Journal of Hygiene 90, 107–115.CrossRefGoogle ScholarPubMed
Jennings, R., Clark, A., Oxford, J. S., Hockley, D. S. & Potter, C. W. (1978). Reactogenicity and immunogenicity of whole and ether-tween split influenza A vaccines in volunteers. Journal of Infectious Diseases 138, 577–580.CrossRefGoogle ScholarPubMed
Jennings, R., Potter, C. W., Massey, P. M. O., Duerden, B. I., Martin, J. & Bevan, A. M. (1981). Responses of volunteers to inactivated influenza virus vaccines. Journal of Hygiene 86, 1–16.CrossRefGoogle ScholarPubMed
Jennings, R., Smith, T. L., Spencer, R. C, Mellersh, A. R., Edey, D., Fenton, P. & Potter, C. W. (1984). Inactivated influenza virus vaccines in man: a comparative study of subunit and split vaccines using two methods for assessment of antibody responses. Vaccine 2, 75–80.CrossRefGoogle Scholar
Kunz, C., Hofmann, H., Moritz, A., Bachmayer, H. & Liehl, E. (1978). Eine neue influenza subunit Vakzine: Hämagglutinations-hemmende Antikörper ein Jahr nach der Impfung. Infection 6, 217–219.CrossRefGoogle Scholar
Lehman, S. J., Wright, P. F. & Patil, K. D. (1980). Antibody decline in children following A/New Jersey/76 influenza virus immunization. Journal of Paediatrics 96, 271–274.Google Scholar
Noble, G. R., Kaye, H. S., O'Brien, R. J., Kendal, A. P., Breoman, D. J., Wright, P. F., Amler, R. W. & Dowdle, W. R. (1977). Persistence of influenza A/New Jersey/76 (HSw1/N1) antibody one year after vaccination. Developments in Biological Standardisation 39, 253–260.Google Scholar
Oxford, J. S., Yetts, R. & Schild, G. C. (1982). Quantitation and analysis of the specificity of post-immunization antibodies to influenza B using single radial haemolysis. Journal of Hygiene 88, 325–333.CrossRefGoogle ScholarPubMed
Pandemic, Working Group of the Medical Research Council (United Kingdom) Committee On Influenza And Other Respiratory Virus Vaccines (1977). Antibody responses and reactogenicity of graded doses of inactivated influenza of A/New Jersey/76 whole-virus vaccine in humans. Journal of Infectious Diseases 136 S, S475–S483.Google Scholar
Parkman, P. D., Galasso, G. J., Top, F. H. Jr & Noble, G. R. (1976). Summary of clinical trials of influenza vaccines. Journal of Infectious Diseases 134, 100–107.CrossRefGoogle Scholar
Potter, C. W., Clark, A., Jennings, R., Schild, G. C, Wood, J. M. & McWilliam, P. K. A. (1980). Reactogenicity and immunogenicity of inactivated influenza A (H1N1) virus vaccine in unprimed children. Journal of Biological Standardisation 8, 35–48.CrossRefGoogle ScholarPubMed
Potter, C. W., Jennings, R., Phair, J. P., Clark, A. & Stuart-Harris, C. H. (1977). Dose-response relationship after immunisation of volunteers with a new, surface-antigenadsorbed influenza virus vaccine. Journal of Infectious Diseases 135, 423–431.CrossRefGoogle ScholarPubMed
Ruben, F. L. & Jackson, G. G. (1972). A new subunit influenza vaccine: acceptability compared with standard vaccines and effect of dose on antigenicity. Journal of Infectious Diseases 125, 656–664.CrossRefGoogle ScholarPubMed
Wood, J. M., Schild, G. C, Newman, R. W. & Seagrott, V. (1977). An improved single-radial-immunodiffusion technique for the assay of influenza haemagglutinin antigen: application for potency determinations of inactivated whole virus and subunit vaccines. Journal of Biological Standardisation 5, 237–247.CrossRefGoogle ScholarPubMed
Zavadova, H., Adam, K., Vonka, V., Domorázková, E., Kratochvílova, M., Burian, V. & Davenport, F. M. (1972). Clinical reactivity and immunogenicity of haemagglutinin influenza vaccine. II. Clinical reactions, haemagglutination-inhibiting and strain- and type-specific complement-fixing antibody responses in infants. Archiv für die gemmte Virusforschung 36. 53–61.Google Scholar