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Antibody response and persistence in volunteers following immunization with varying dosages of a trivalent surface antigen influenza virus vaccine

Published online by Cambridge University Press:  19 October 2009

R. Jennings ,
T. L. Smith ,
A. R. Mellersh ,
A. Clark ,
R. C. Spencer  and
C. W. Potter
R. Jennings
Affiliation:
Departments of Virology and Medical Microbiology, Medical School, University of Sheffield, Sheffield S10 2RX
T. L. Smith
Affiliation:
Departments of Virology and Medical Microbiology, Medical School, University of Sheffield, Sheffield S10 2RX
A. R. Mellersh
Affiliation:
Departments of Virology and Medical Microbiology, Medical School, University of Sheffield, Sheffield S10 2RX
A. Clark
Affiliation:
Departments of Virology and Medical Microbiology, Medical School, University of Sheffield, Sheffield S10 2RX
R. C. Spencer
Affiliation:
Departments of Virology and Medical Microbiology, Medical School, University of Sheffield, Sheffield S10 2RX
C. W. Potter
Affiliation:
Departments of Virology and Medical Microbiology, Medical School, University of Sheffield, Sheffield S10 2RX
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Summary

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The serum antibody responses and 50% protective levels (PL50) of antibody were determined, using the SRH test, at one and twelve months post-vaccination in a group of student volunteers immunized with one of three dosages of a trivalent surface-antigen influenza virus vaccine, or with placebo.

It was found that, for the H3, H1 and B haemagglutinin components present in the vaccine, a dose of 6 μg HA elicited high serum antibody responses at one month post-immunization. High mean antibody levels and a high incidence of volunteers with PL50 values of antibody against each of the HA components of the vaccine remained in the volunteer group twelve months later. The results are discussed in relation to the vaccine dosage used and the nature of the population immunized.

Type
Research Article
Information
Journal of Hygiene , Volume 94 , Issue 1 , February 1985 , pp. 87 - 95
Copyright
Copyright © Cambridge University Press 1985

References

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