The end of the last millennium witnessed an unprecedented degree of public awareness
regarding mental disorder as well as motivation for policy change. Like Sartorius, we contend that
the continued stigmatization of mental illness may well be the central issue facing the field, as
nearly all attendant issues (e.g., standards of care, funding for basic and applied research efforts)
emanate from professional, societal, and personal attitudes towards persons with aberrant
behavior. We discuss empirical and narrative evidence for stigmatization as well as historical
trends regarding conceptualizations of mental illness, including the field's increasing focus
on genetic and neurobiological causes and determinants of mental disorder. We next define stigma
explicitly, noting both the multiple levels (community, societal, familial, individual) through which
stigma operates to dehumanize and delegitimize individuals with mental disorders and the impact
of stigma across development. Key developmental psychopathology principles are salient in this
regard. We express concern over the recent oversimplification of mental illness as “brain
disorder,” supporting instead transactional models which account for the dynamic interplay
of genes, neurobiology, environment, and self across development and which are consistent with
both compassion and societal responsibility. Finally, we consider educational and policy-related
initiatives regarding the destigmatization of mental disorder. We conclude that attitudes and
policy regarding mental disorder reflect, in microcosmic form, two crucial issues for the next
century and millennium: (a) tolerance for diversity (vs. pressure for conformity) and (b)
intentional direction of our species' evolution, given fast-breaking genetic advances.