Coastal morphological changes can be assessed using shoreline position observations from space. However, satellite-derived waterline (SDW) and shoreline (SDS; SDW corrected for hydrodynamic contributions and outliers) detection methods are subject to several sources of uncertainty and inaccuracy. We extracted high-spatiotemporal-resolution (~50 m-monthly) time series of mean high water shoreline position along the Columbia River Littoral Cell (CRLC), located on the US Pacific Northwest coast, from Landsat missions (1984–2021). We examined the accuracy of the SDS time series along the mesotidal, mildly sloping, high-energy wave climate and dissipative beaches of the CRLC by validating them against 20 years of quarterly in situ beach elevation profiles. We found that the accuracy of the SDS time series heavily depends on the capability to identify and remove outliers and correct the biases stemming from tides and wave runup. However, we show that only correcting the SDW data for outliers is sufficient to accurately measure shoreline change trends along the CRLC. Ultimately, the SDS change trends show strong agreement with in situ data, facilitating the spatiotemporal analysis of coastal change and highlighting an overall accretion signal along the CRLC during the past four decades.