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Milk, Blood Lipids and Coronary Heart Disease (CHD) - ‘The Myth and the Evidence’

Published online by Cambridge University Press:  27 February 2018

Anne M. Minihane
Anne M. Minihane*
Affiliation:
Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Reading RG6 6AP, UK
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Extract

Chronic diet related diseases such as cardiovascular disease (CVD) and cancers account for the vast majority (∼ 65%) of total mortality in the UK (Figure 1). In westernised countries average life expectancy is rapidly increasing with the ratio of people of working age to people over 65 estimated to fall from about to 4:1 to 2.5:1 by the year 2040. These ageing population demographics have placed an almost unbearable strain on the health care systems of these countries. As a result there has been increased focus on the use of diet as a modifiable means of preventing or delaying the onset of disease. This approach in addition to being cost effective would ensure that for the individual who is living longer that they also remain healthier for longer, developing chronic life threatening diseases at an older age.

Type
Research Article
Information
BSAP Occasional Publication , Volume 29: Dairying: Using Science to Meet Consumers’ Needs , 2004 , pp. 199 - 213
Copyright
Copyright © Cambridge University Press 2004

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References

Agerbaeck, M., Gerdes, L.U. and Richelsen, B. (1995) Hypocholesterolaemic effect of a new feremnted milk product in middle-aged men. European Journal of Clinical Nutrition, 49, 346–352.Google Scholar
Anitshkow, N. (1913) Changes in the rabbit aorta due to experimentally induced cholesterolsteatosis. Beitrage zur pathologishen Anatomieund zur allgemeinen Pathologie, 56, 379–404.Google Scholar
Barr, S.I., McCarron, D.A., Heaney, R.P., Dawson-Hughes, B., Berga, S.L., Stern, J.S. and Oparil, S. (2000) Effects of increased consumption of fluid milk on energy and nutrient intake, body weight, and cardiovascular risk factors in healthy older adults. Journal of American Dietetic Association, 100, 810–817.Google Scholar
Buonopane, G.J., Kilara, A., Smith, J.S. and McCarthy, R.D. (1992) Effect of skim milk supplementation on blood cholesterol concentration, blood pressure, and triglycerides in a free-living human population. Journal of the American College of Nutrition, 11, 56–67.Google Scholar
Chilliard, Y., Ferlay, A., Mansbridge, R.M. and Doreau, M. (2000) Ruminant milk fat plasticity: nutritional control of saturated, polyunsaturated, trans and conjugated fatty acids. Annals of Zootechnology, 49,181–205.Google Scholar
Committee on Medical Aspects of Food Policy (COMA) (1994) Nutritional Aspects of Cardiovascular Disease. Report on Health and Social Subjects No 46. London: HMSO.Google Scholar
Demeyer, D. and Doreau, M. (1999) Targets and procedures for altering ruminant meat and milk. Proceedings of the Nutrition Society, 58, 593–607.Google Scholar
Golay, A., Ferrara, J.M., Felber, J.P. and Schneider, H.(1990) Cholesterol-lowering effect of skim milk from immunized cows in hypercholesterolaemic patients. American Journal of Clinical Nutrition, 52, 1014–1019.CrossRefGoogle Scholar
Ha, Y.L., Storkson, J. and Pariza, M.W. (1990) Inhibition of benzo(a)pyrene-induced mouse forestomach neoplasia by conjugated dienoic derivatives of linoleic acid. Cancer Research, 50, 1097–1101.Google ScholarPubMed
Hegsted, D.M., Ausman, L.M., Johnson, J.A. and Dallal, G.E. (1993) Dietary fat and serum lipids an evaluation of the experimental data. American Journal of Clinical Nutrition, 57, 875–883.Google Scholar
Hokanson, J. and Austin, M.A. (1996) Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol. Journal of Cardiovascular Risk, 3, 213–219.Google Scholar
Hu, F.B., Rimm, E.B., Stampfer, M.J., Ascherio, A., Spiegelman, D. and Willett, W.C. (2000) Prospective study of major dietary patterns and risk of coronary heart disease in men. American Journal of Clinical Nutrition, 72, 912–921.Google Scholar
Keys, A., Anderson, J.T. and Grande, F. (1965) Serum cholesterol responses to changes in diet: Particular saturated fatty acids in the diet. Metabolism, 14, 776–787.CrossRefGoogle ScholarPubMed
Knekt, P., Jarvinen, R., Seppanen, R., Pukkala, E. and Aromaa, A.(1996) Intake of dairy products and the risk of breast cancer. British Journal of Cancer, 73, 687–691.Google Scholar
Kritchevsky, D., Tepper, S.A., Wright, S., Tso, P. and Czarnecki, S.K. (2000) Influence of conjugated linoleic acid (CLA) on establishment and progression of atherosclerosis in rabbits. Journal of American Colleges of Nutrition, 19, 472S–477S Google Scholar
Mattos, W. and Palmquist, D.L. (1974) Increasing polyunsaturated fatty acid yields in milk of cows fed protected fat. Journal of Dairy Science, 57, 1050–1054.Google Scholar
McCance, and Widdowson, (1998) The Composition of Foods: Fatty Acid supplement. London: HMSO.Google Scholar
Menotti, A., Kromhout, D., Blackburn, H., Fidanza, F, Buzina, R., Nissinen, A (1999) Food intake patterns and 25-year mortality from coronary heart disease:cross cultural correlations in the Seven Countries Study. The Seven Countries Study Research Group. European Journal of Epidemiology, 15, 507–515 Google Scholar
Mensink, R.P. and Katan, M.B. (1992) Effect of dietary fatty acids on serum lipids and lipoproteins. A meta-analysis of 27 trials. Arteriosclerosis and Thrombosis, 12, 911–919.Google Scholar
Mensink, R.P. and Zock, P.L. (1998) Lipoprotein metabolism and trans fatty acids. In: Sebedio, J.L. and Christie, W.W. (eds.). Dundee, The Oily Press.Google Scholar
Minihane, A.M., Khan, S., Leigh-Firbank, E.C., Talmud, P., Wright, J.W., Murphy, M.C., Griffin, B.A. and Williams, C.M. (2000) ApoE polymorphism and fish oil supplementation in subjects with an atherogenic lipoprotein phenotype (ALP). Arteriosclerosis, Thrombosis and Vascular Biology, 20, 1990–1997.Google Scholar
Ness, A.R., Smith, G.D. and Hart, C. (2001) Milk coronary heart disease and mortality. Journal of Epidemiology and Community Health, 55, 379–382.Google Scholar
Noakes, M., Nestel, P.J. and Clifton, P.M. (1996) Modifying the fatty acid profile of dairy products through feedlot technology lowers plasma cholesterol of human consuming the products. American Journal of Clinical Nutrition, 63, 42–46.Google Scholar
Office for National Statistics. 2001. Available from http://www.statistics.gov.uk. Scandinavian Simvastatin Survival Study Group (1994) Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet, 344, 1383–1389.Google Scholar
Shepherd, J., Cobbe, S.M., Ford, I., Isles, C.G., Lorimer, A.R., MacFarlane, P.W. and Packard, C.J. (1995) Prevention of coronary heart disease with pravastatin in men with hypercholesterolaemia. New England Journal of Medicine, 333, 1301–1307.CrossRefGoogle Scholar
St-Onge, M.P., Farnworth, E.R. and Jones, P.J.H (2000) Consumption of fermented and non-fermented dairy products: effects on cholesterol concentrations and metabolism. American Journal of Clinical Nutrition, 71, 674–681.Google Scholar
Willett, W.C., Stampfer, M.J., Manson, J.E., Colditz, G.A., Speizer, F.E., Rosner, B.A., Sampson, L.A. and Hennekens, C.H. (1993) Intake of trans fatty acids and risk of coronary heart disease among women. The Lancet, 341, 581–585.Google Scholar
Williams, C.M. (2000). Dietary fatty acids and human health. Annals of Zootechnology, 49, 165–180.CrossRefGoogle Scholar