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Intake and sources of phylloquinone (vitamin K1): variation with socio-demographic and lifestyle factors in a national sample of British elderly people

Published online by Cambridge University Press:  09 March 2007

C. W. Thane ,
A. A. Paul ,
C. J. Bates ,
C. Bolton-Smith ,
A. Prentice  and
M. J. Shearer
C. W. Thane*
Affiliation:
MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, UK
A. A. Paul
Affiliation:
MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, UK
C. J. Bates
Affiliation:
MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, UK
C. Bolton-Smith
Affiliation:
MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, UK
A. Prentice
Affiliation:
MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, UK
M. J. Shearer
Affiliation:
Vitamin K Research & Diagnostic Units, Haemophilia Centre, St Thomas' Hospital, London SE1 7EH, UK
*
*Corresponding author:Mr C. W. Thane, fax +44 1223 437515, email [email protected]
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Abstract

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Intake and sources of phylloquinone (vitamin K1) were examined according to socio-demographic and lifestyle factors in free-living British people aged 65 years and over, from the 1994–5 National Diet and Nutrition Survey. Complete 4-d weighed dietary records were obtained from 1152 participants living in private households. Using newly-available, mainly UK-specific food content data, the weighted geometric mean intake of phylloquinone was estimated at 65 (95 % CI 62, 67) μg/d for all participants, with higher intakes in men than in women (70 v. 61 μg/d respectively, P<0·01). The mean nutrient densities of phylloquinone intake were 9·3 and 10·5 μg/MJ for men and women respectively (P<0·01), after adjusting for age group, region and smoking status. Of all the participants, 59 % had phylloquinone intakes below the current guideline for adequacy of 1 μg/kg body weight per d. Participants aged 85 years and over, formerly in manual occupations, or living in Scotland or in northern England reported lower phylloquinone intakes than their comparative groups. Overall, vegetables contributed 60 % of total phylloquinone intake, with cooked green vegetables providing around 28 % of the total. Dietary supplements contributed less than 0·5 % of phylloquinone intake. Participants living in northern England or in Scotland, in particular, derived less phylloquinone from vegetables than those living in southern England.

Keywords

Vitamin K intakeFood sourcesElderly
Type
Research Article
Information
British Journal of Nutrition , Volume 87 , Issue 6 , June 2002 , pp. 605 - 613
Copyright
Copyright © The Nutrition Society 2002

References

Binkley, NC & Suttie, JW (1995) Vitamin K nutrition and osteoporosis. Journal of Nutrition 125, 1812–1821.CrossRefGoogle ScholarPubMed
Bolton-Smith, C, Price, RJG, Fenton, ST, Harrington, DJ & Shearer, MJ (2000 a) Compilation of a provisional UK database for the phylloquinone (vitamin K1) content of foods. British Journal of Nutrition 83, 389–399.Google ScholarPubMed
Bolton-Smith, C, Price, RJG & Shearer, MJ (2000 b) Decreasing phylloquinone (vitamin K1) and total fat intake in a 10-year longitudinal study of Scottish adults. Proceedings of the Nutrition Society 59, 24A.Google Scholar
Booth, SL, O'Brien-Morse, ME, Dallal, GE, Davidson, KW & Gundberg, CM (1999) Response of vitamin K status to different intakes and sources of phylloquinone-rich foods: comparison of younger and older adults. American Journal of Clinical Nutrition 70, 368–377.CrossRefGoogle ScholarPubMed
Booth, SL, Pennington, JAT & Sadowski, JA (1996) Food sources and dietary intakes of vitamin K1 (phylloquinone) in the American diet: Data from the FDA Total Diet Study. Journal of the American Dietetic Association 96, 149–154.CrossRefGoogle ScholarPubMed
Booth, SL, Sokoll, LJ, O'Brien, ME, Tucker, K, Dawson-Hughes, B & Sadowski, JA (1995) Assessment of dietary phylloquinone intake and vitamin K status in postmenopausal women. European Journal of Clinical Nutrition 49, 832–841.Google ScholarPubMed
Booth, SL, Tucker, KL, Chen, H, Hannan, MT, Gagnon, DR, Cupples, LA, Wilson, PWF, Ordovas, J, Schaefer, EJ, Dawson-Hughes, B & Kiel, DP (2000) Dietary vitamin K intakes are associated with hip fracture but not with bone mineral density in elderly men and women. American Journal of Clinical Nutrition 71, 1201–1208.CrossRefGoogle Scholar
Davidson, KW, Booth, SL, Dolnikowski, GG & Sadowski, JA (1996) The conversion of phylloquinone to 2,3-dihydro-vitamin K1 during the hydrogenation of vegetable oils. Journal of Agricultural and Food Chemistry 44, 980–983.CrossRefGoogle Scholar
Department of Health (1991) Dietary Reference Values for Food Energy and Nutrients for the United Kingdom. Report on Health and Social Subjects, no. 41. London: HMSO.Google Scholar
Fenton, ST, Price, RJ, Bolton-Smith, C, Harrington, D & Shearer, MJ (1997) Nutrient sources of phylloquinone (vitamin K1) in Scottish men and women. Proceedings of the Nutrition Society 56, 301A.Google Scholar
Ferland, G & Sadowski, JA (1992 a) The vitamin K1 (phylloquinone) content of green vegetables: effects of plant maturation and geographical growth location. Journal of Agricultural and Food Chemistry 40, 1874–1877.CrossRefGoogle Scholar
Ferland, G & Sadowski, JA (1992 b) The vitamin K1 (phylloquinone) content of edible oils: effects of heating and light exposure. Journal of Agricultural and Food Chemistry 40, 1869–1873.CrossRefGoogle Scholar
Finch, S, Doyle, W, Lowe, C, Bates, CJ, Prentice, A, Smithers, G & Clarke, PC (1998) National Diet and Nutrition Survey: People Aged 65 Years and Over, vol. 1. Report of the Diet and Nutrition Survey. London: The Stationery Office.Google Scholar
Goldberg, GR, Black, AE, Jebb, SA, Cole, TJ, Murgatroyd, PR, Coward, WA & Prentice, AM (1991) Critical evaluation of energy intake data using fundamental principles of energy physiology: 1. Derivation of cut-off limits to identify under-reporting. European Journal of Clinical Nutrition 45, 569–581.Google Scholar
Institute of Medicine (2001) Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc, pp. 127–154. Washington, DC: National Academy Press.Google Scholar
Jie, K-SG, Bots, ML, Vermeer, C, Witteman, CM & Grobbee, DE (1995) Vitamin K intake and osteocalcin levels in women with and without aortic atherosclerosis: a population-based study. Atherosclerosis 116, 117–123.CrossRefGoogle ScholarPubMed
Luo, G, Ducy, P, McKee, MD, Pinero, GJ, Loyer, E, Behringer, RR & Karsenty, G (1997) Spontaneous calcification of arteries and cartilage in mice lacking matrix Gla protein. Nature 386, 78–81.CrossRefGoogle ScholarPubMed
Price, R, Fenton, S, Shearer, MJ & Bolton-Smith, C (1996) Daily and seasonal variation in phylloquinone (vitamin K1) intake in Scotland. Proceedings of the Nutrition Society 55, 244A.Google Scholar
Schofield, WN, Schofield, C & James, WPT (1985) Basal metabolic rate. Human Nutrition: Clinical Nutrition 39C, Suppl. 1, 1–96.Google Scholar
Schurgers, LJ, Dissel, PE, Spronk, HM, Soute, BA, Dhore, CR, Cleutjens, JP & Vermeer, C (2001) Role of vitamin K and vitamin K-dependent proteins in vascular calcification. Zeitschrift für Kardiologie 90, Suppl. 3, 57–63.CrossRefGoogle ScholarPubMed
Schurgers, LJ, Geleijnse, JM, Grobbee, DE, Pols, HAP, Hofman, A, Witteman, JCM & Vermeer, C (1999) Nutritional intake of vitamins K1 (phylloquinone) and K2 (menaquinone) in the Netherlands. Journal of Nutritional and Environmental Medicine 9, 115–122.CrossRefGoogle Scholar
Shearer, MJ (1997) The roles of vitamins D and K in bone health and osteoporosis prevention. Proceedings of the Nutrition Society 56, 915–937.CrossRefGoogle Scholar
Shearer, MJ (2000) Role of vitamin K and Gla proteins in the pathophysiology of osteoporosis and vascular calcification. Current Opinion in Clinical Nutrition and Metabolic Care 3, 433–438.CrossRefGoogle ScholarPubMed
Shearer, MJ & Bolton-Smith, C (2000) The UK food data-base for vitamin K and why we need it. Food Chemistry 68, 213–218.CrossRefGoogle Scholar
Smith, P & Lowe, C (1998) National Diet and Nutrition Survey: People aged 65 Years and Over. A Report of the Feasibility Study (January–April 1994). London: Social and Community Planning Research.Google Scholar
Sokoll, LJ, Booth, SL, O'Brien, ME, Davidson, KW, Tsaioun, KI & Sadowski, JA (1997) Changes in serum osteocalcin, plasma phylloquinone, and urinary γ-carboxyglutamic acid in response to altered intakes of dietary phylloquinone in human subjects. American Journal of Clinical Nutrition 65, 779–784.CrossRefGoogle ScholarPubMed
Szulc, P, Chapuy, MC, Meunier, PJ & Delmas, PD (1993) Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture in elderly women. Journal of Clinical Investigation 91, 1769–1774.CrossRefGoogle ScholarPubMed
Szulc, P, Chapuy, MC, Meunier, PJ & Delmas, PD (1996) Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture: a three year follow-up study. Bone 18, 487–488.CrossRefGoogle ScholarPubMed
Vermeer, C, Jie, K-SG & Knapen, MHJ (1995) Role of vitamin K in bone metabolism. Annual Review of Nutrition 15, 1–22.CrossRefGoogle ScholarPubMed